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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | Recurrence of a deep neck infection: a clinical indication of an underlying congenital lesion显示文摘 | NUSBAUM A O SOM P M ROTHSCHILD M A | 1999 | Arch Otolaryngol Head Neck Surg1999，125，： | 1 |
| 3 | Convergent rhythm generation from divergent cellular mechanisms显示文摘 | Rodriguez JC Blitz DM Nusbaum MP | 2013 | J Neurosci2013，33，18： | 1 |
| 4 | Consolidation during sleep of perceptual learning of spoken language显示文摘 | Fenn KM Nusbaum HC Margoliash D | 2003 | Nature2003，425，6958： | 1 |
| 5 | Consolidation during sleep of perceptual learning of spoken language 显示文摘 | Feen KM Nusbaum HC Margoliash D | 2003 | Nature2003，425，6958： | 1 |
| 6 | Global changes in cerebral white matter diffusion in normal aging显示文摘 | Nusbaum AO Tang CY Buchsbaum MS | 1999 | Proc Intl Soc Magn Reson Med1999，7，： | 1 |
| 7 | Coll(dbbip) 22+complex rivals tri-iodide/Iodide redox mediator in dyesensitized photovoltaic cells显示文摘 | Nusbaumer H Jacques-E Moser J E | 2001 | Phys Chem B2001，105，10： | 1 |
| 8 | LRRFIP1,a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome显示文摘 | Soler G Nusbaum S Varet B | | 0，，： | 1 |
| 9 | In vitro model of mycobacteria and HIV-1 co-infection for drug discovery显示文摘 | Sudhamathi Vijayakumar Sarah Finney John Rebecca J. Nusbaum Monique R. Ferguson Jeffrey D. Cirillo Omonike Olaleye Janice J. Endsley | 2013 | Tuberculosis2013，，： | 1 |
| 10 | A YAC-based physical map of the mouse genome显示文摘 | Nusbaum C Slonim D Harris KL | 1999 | Nat Genet1999，22，4： | 1 |
| 11 | Consolidation during sleep of perceptual learning of spoken language 显示文摘 | Fenn KM Nusbaum HC Margoliash D | 2003 | Nature2003，425，6958： | 1 |
| 12 | Early membrane events in polymorphonuclear cell (PMN) apoptosis: membrane blebbing and vesicle release, CD43 and CD16 down-regu- lation and phosphatidylserine externalization显示文摘 | Nusbaum P Laine C Seveau S Lesavre P Halbwachs-Mecarelli L | 2004 | Biochem Soc Trans2004，32，3： | 1 |
| 13 | Preliminary studies of a newly developed subunit vaccine for channel cat- fish virus disease 显示文摘 | AWAD M A NUSBAUM K E BRADY Y J | 1989 | Journal of Aquatic Animal Health1989，1，7： | 1 |
| 14 | Regional and global changes in cerebral diffusion with normal aging显示文摘 | Nusbaum AO Tang CY Buchsbaum MS | 2001 | Am J Neuroradiol2001，22，1： | 1 |
| 15 | Incorporating wound healing strategies to improve palliation (symptom man- agement) in patients with chronic wounds 显示文摘 | Alvarez OM Kalinsk C Nusbaum J | 2007 | J Palliate Med2007，10，5： | 1 |
| 16 | Use of B-type natriuretic peptide in the detection of myocardial ischemia显示文摘 | Staub D Nusbaumer C Zellweger MJ | 2006 | Am Heart J2006，151，： | 1 |
| 17 | Amplification,cnhartced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial orgigin显示文摘 | Libermann TA Nusbaum HR Razon N | 1985 | Nature1985，313，： | 1 |
| 18 | Sleep-dependent consolidation of auditory discrimination learning in adult starlings 显示文摘 | Timothy P Brawn Howard C Nusbaum Daniel Margoliash | 2010 | J Neurosci2010，30，2： | 1 |
| 19 | A YAC-based physical map of the mouse genome 显示文摘 | Nusbaum C Slonim DK Harris KL | 1999 | Nat Genet1999，22，4： | 1 |
| 20 | Correlation between the degree of contrast enhancement and the volume of peritumoral edema in meningiomas and malignant gliomas显示文摘 | Holodny AI Nusbaum AO Festa S | 1999 | Neuroradiology1999，41，： | 1 |
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