|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells显示文摘OBJECTIVE: Prostate cancer(PCa) is a major health concern. Calliandra portoricensis(CP) is traditionally known for its analgesic, anti-ulcerogenic and anticonvulsant properties. However, its antiproliferative properties for PCa still need to be investigated. METHODS: Antioxidant activities of CP were determined by 1,1-diphenyl-2-picryhydrazyl(DPPH) and hydroxyl(OH-) radicals-scavenging methods. PC-3 and LNCa P(androgen-refractory and androgendependent PCa-derived cell lines) were cultured and treated with CP(10, 50 and 100 μg/m L). Effects of CP on cells were determined by cytotoxicity assay(lactate dehydrogenase, LDH) and viability assay(sodium 3′-[1-(phenylaminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro) benzene sulfonic acid hydrate, XTT). DNA fragmentation was detected by cell death detection enzyme-linked immunosorbent assay plus kit. CP was tested as an inhibitor of angiogenesis using chicken chorioallantoic membrane(CAM) assay. RESULTS: CP showed significant scavenging of DPPH and OH- radicals. CP significantly(P<0.05) inhibited lipid peroxidation in a dose-dependent manner. Precisely, CP(10, 50 and 100 μg/m L) inhibited PC-3 and LNCa P growth by 7%, 74% and 92%, and 27%, 73%, and 85% respectively at 48 h. CP had low toxicity in vitro at its half inhibitory concentration dose. Detection of cell death induced by CP at 50 μg/m L showed higher enrichment factors in LNCa P(7.38±0.95) than PC-3(3.48±0.55). Also, treatment with CP(50 μg/m L) significantly reduced network of vessels in CAM, suggesting its antiangiogenic potential. CONCLUSION: Calliandra portoricensis elicited antioxidant, antiangiogenic and antiproliferative effects in PCa cells. | Oluwatosin Adaramoye Bettina Erguen Olubukola Oyebode Bianca Nitzsche Michael H?pfner Klaus Jung Anja Rabien | 2015 | Journal of Integrative Medicine2015，13，3： | 2 |
| 2 | The influence of covalently linked and free polyethylene glycol on the structural and release properties of rhBMP-2 loaded microspheres 显示文摘 | Lochmann A Nitzsche H yon Einem S | 2010 | Journal of ContinUed Release: Official Journal of the ControUed Release Society2010，147，1： | 1 |
| 3 | Is positron emission tomography an acute noninvasive alternative to sentinel lymph node biopsy in breast cancer patients 显示文摘 | Nitzsche E Moch H | 2003 | J Natl Cancer Inst2003，95，14： | 1 |
| 4 | Formation of 4-vinylguaiacol during production of Bavarian wheatbeer 显示文摘 | NARZISS L MIEDANER H NITZSCHE F | 1990 | Monatssehr Brauwiss1990，43，： | 1 |
| 5 | Fabrication and characteriza- tion of a biomimetic composite scaffold for bone defect repair 显示文摘 | Nitzsche H Lochmann A Metz H | 2010 | Biomed Mater Res2010，94，1： | 1 |
| 6 | The influence of cova- lently linked and free polyethylene glycol on the structural and release properties of rhBMP - 2 loaded microspheres 显示文摘 | Lochmann A Nitzsche H Von Einem S | 2010 | J Control Release2010，1，： | 1 |
| 7 | Modu lation of renal eortieablood flow during static exer- cise in humans 显示文摘 | Middlekauff H R Nitzsche E U Nguyen A H | 1997 | Circ Res1997，80，1： | 1 |
| 8 | Heat shock protein 90 is a promising target for effective growth inhibitionof gastrointestinal neuroendocrine tumors显示文摘 | Christoph Gloesenkamp Bianca Nitzsche Alice Lim Emmanuel Normant Evan Vosburgh Mark Schrader Matthias Ocker Hans Scherübl Michael H?pfner | 2012 | International Journal of Oncology2012，，： | 1 |
| 9 | Glycoalkaloid content of potatoes cultivars and its relationship to location,year and taste显示文摘 | ROSS H PASEMANN P NITZSCHE W | 1978 | Zeitschrift für Pflanzenzüchtung1978，80，： | 1 |
| 10 | 妊娠疟疾报道1例(德)显示文摘We report on a 25- year- old prima gravida in the 26th week of pregnancy with a malaria tropica infection from Kenya. A prior therapy for Lues latens seropositiva had been successful. Hospital admission was because of uncommon fever, chronic anemia and increasing thrombocytopenia. After typical attacks of fever malaria tropica was diagnosed in blood slides; because of this an intravenous therapy with chinin and clindamycin over 8 days was started. As a side effect of the chinin therapy premature labour resulted, which necessitated tocolytic treatment. The patient returned to give birth in the 40th week of pregnancy; a girl with a birth weight of 3560 g was born (APGAR score 9/10/10, pHNA 7.27). Signs of connatal lues did not show up in the first 14 days of the infant’ s life. In Europe malaria infections during pregnancy are rarely described in the literature. However, for a differential diagnosis of uncommon attacks of fever in pregnancy blood slides are recommended. In principle in pregnancy travel to malaria-endemic areas should be avoided. After the 16th week of pregnancy mefloquine is the current drug of choice for chemoprophylaxis. | Hnseroth K. Nitzsche K. Distler W. 李欢 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员