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| 1 | Effect of Jiaweiwumei decoction on regulatory T cells and interleukin-10 in a rat model of ulcerative colitis显示文摘OBJECTIVE:To investigate the effect of a decoction made from the Traditional Chinese Medicine Wumei pill,on regulatory T cells and interleukin-10(IL-10) in a rat model of ulcerative colitis induced by2,4,6-trinitrobenzene sulfonic acid(TNBS).METHODS:Rat ulcerative colitis was induced with TNBS.All modeled rats were randomly divided into six groups:normal control group;model group;sulfasalazine suppositories treatment group;and high,moderate,and low dosage of Jiaweiwumei decoction groups(12 rats each).Colon injury index was evaluated after 14 days.After peripheral blood lymphocyte separation,CD4 + T cells and CD4+/CD25+ T cell percentage was detected by flow cytometry.The content of IL-10 in serum and intestinal mucosa tissue was detected by sandwich enzyme-linked immunosorbent assay.RESULTS:Colon injury indices in the decoction groups were effectively reduced,compared with the model group(P < 0.05).Compared with that of the control group,the CD4+/CD25+ to CD4+ T lymphocyte ratio of the model group was significantly lower,while the decoction treatment improved the CD4 +/CD25 + to CD4 + T lymphocyte ratio(P <0.05).The serum and mucosal IL-10 content of the model group was significantly lower(P < 0.05) than that in the control group,while the decoction group had significantly higher serum and intestinal mucosal IL-10 content than that in the model group(P < 0.05).The regulatory T cell content was negatively correlated with the colonic injury index(r = 0.68,P < 0.05),and positively correlated with the content of serum IL-10(r = 0.87,P < 0.05) and intestinal mucosal IL-10(r= 0.79,P < 0.05).CONCLUSION:Jiaweiwumei decoction had significant effects on regulatory T cells and IL-10 in rats with TNBS-induced ulcerative colitis. | Tao Mei Wang Xuyan Wang Aiqin Gao Ninghan Pan Jie Liu Xiaoquan Wang Xiaoye | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 14 |
| 2 | Prostate cancer: molecular and cellular mechanisms and their implications in therapy resistance and disease progression显示文摘Prostate cancer is among the most common malignancies in Western countries, and its incidence is rapidly rising in Asia where it was traditionally considered an uncommon tumor. Our understanding of the disease and management strategies continue to evolve. The first revolution of its treatment was in the 1940s when hormonal therapy was used to treat patients. | Ninghan Feng Jiaoti Huang | 2019 | Asian Journal of Andrology2019，21，3： | 5 |
| 3 | 麻风病全基因组关联分析显示文摘背景:由于麻风分枝杆菌宿主的局限性和难以在体外培养,限制了对麻风病的研究及其生物学方面的了解。宿主的遗传因素不仅影响对麻风菌的易感性,也影响麻风病的病程。方法:采用Illumina Human 610-Quad BeadChips对706个麻风病例及1225名正常对照人群进行全基因组扫描,扫描的结果采用PLINK软件进行统计学分析。根据分析结果对可能阳性的93个SNPs位点在3254个麻风病例及5955名正常对照中验证,以确定麻风病的易感基因。同时我们在麻风病的不同临床型别中进行了异质性检验,以期发现与型别相关的易感基因。结果:(1)研究发现位于6个区域的15个SNPs达到了全基因关联研究水平(P<1.0×10^(-8)),定位了6个麻风病的易感基因:HLA-DR,RIPK2,TNFSF15,CCDC122,C13ORF31和NOD2。另外LRRK2基因对应SNP的P值为5.10×10,提示该基因可能为麻风病的易感基因。(2)研究发现5个SNPs在多菌型麻风病中的遗传效力强于少菌型。结论:位于调节固有免疫NOD2介导的信号通路中基因的变异与麻风病的易感性相关。 | 张福仁 黄薇 陈树民 孙良丹 刘红 李毅 崔勇 颜潇潇 杨海涛 杨荣德 初同胜 张弛 张林 韩建文 于功奇 权晟 于永翔 张铮 史本青 张连华 程晖 王昌媛 林燕 郑厚峰 付希安 左先波 王强 龙恒 孙一萍 程义林 田洪青 周伏圣 刘华绪 陆闻生 何素敏 杜文莉 沈珉 金祺祎 王颖 Hui-Q iLow Tantoso Erwin Ninghan Yang 李金勇 赵欣 娇曰林 毛立国 殷刚 姜珍霞 王晓东 于京平 胡宗厚 巩翠华 柳玉强 刘瑞玉 王德民 魏东 刘金献 曹巍鲲 曹恒仲 李永平 阎维国 魏世玉 王奎军 Martin L Hibberd 杨森 张学军 刘建军 | 2010 | 中国麻风皮肤病杂志2010，，1： | 4 |
| 4 | Single-row laser beam with energy strengthened ends for continuous scanning laser surface hardening of large metal components显示文摘For laser surface hardening of metal components with large superficies,a binary grating is proposed to generate single-row laser beam with proportional-intensity diffractive orders.To obtain a uniform hardened band distribution and improve the wear resistance of the sample surface,the binary grating is designed to produce single-row laser beam with energy strengthened at the two ends.The profile of the laser beam spot was designed to be strip with high length-width ratio to improve the machining efficiency of the hardening of large surfaces.A new advantage is suggested to obtain proportional intensity spots with evenness.The design results show that the diffractive efficiency of the binary grating is more than 70%,and the uniformity is less than 3%.The surface profile of the grating fabricated was measured,which shows that the fabrication error is less than 2%.The application of the binary grating in the laser surface hardening of metal components with large superficies is experimentally investigated,and the results show that the hardness distribution of the modified layer is more uniform than that hardened by Gaussian laser beam or array spots with equal intensity distribution. | LI ShaoXia YU Gang ZHANG JingChuan TAN QiaoFeng XU NingHan SUN PeiPei ZHENG CaiYun | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 3 |
| 5 | Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk:a meta-analysis显示文摘Objective:The association between ribonuclease L(RNASEL)gene polymorphisms and prostate cancer risk has been widely reported,but the results of these studies remained controversial and underpowered.We performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer risk.Methods:Odds ratios(ORs)with 95%confidence intervals(CIs) were estimated to assess the association between RNASEL polymorphisms and prostate cancer risk.Results:A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans(Gln/Gln vs Arg/Arg:OR=2.50,95%CI=1.28-4.87;Gln/Gln vs Gln/Arg+Arg/Arg:OR=2.54,95%CI=1.30-4.95),but not in Europeans and Asians.Additionally,the Asp541Glu polymorphism was associated with increased total prostate cancer risk(Glu-allele vs Asp-allele:OR=1.04,95%CI=1.01-1.07;Glu/Glu vs Asp/Asp:OR=1.22,95%CI= 1.03-1.46;Glu/Glu vs Glu/Asp+Asp/Asp:OR=1.09,95%CI=1.02-1.16).In the stratified analysis for the Asp541Glu polymorphism,there was a significantly increased prostate cancer risk in Africans and Europeans,and in hospital-based prostate cancer cases.Conclusion:The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers. | Yuanyuan Mi Qianqian Yu Zhichao Min Bin Xu Lifeng Zhang Wei Zhang Ninghan Feng L ixin Hua | 2010 | The Journal of Biomedical Research2010，24，5： | 2 |
| 6 | VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization显示文摘 | Sharon Lim Yin Zhang Danfang Zhang Fang Chen Kayoko Hosaka Ninghan Feng Takahiro Seki Patrik Andersson Jingrong Li Jingwu Zang Baocun Sun Yihai Cao | 2014 | Cell Reports2014，，： | 1 |
| 7 | Systematic review and meta-analysis of COX-2 expression and polymorphisms in prostate cancer显示文摘 | Ning Shao Ninghan Feng Yang Wang Yuanyuan Mi Tian Li LiXin Hua | 2012 | Molecular Biology Reports2012，，12： | 1 |
| 8 | Modeling the Damage and Self-healing Behaviors of Plasticized PVC Gels显示文摘Plasticized polyvinyl chloride(PVC)gel is a type of electroactive polymers,which has potentials to be applied as soft actuators.However,few studies have been performed to investigate the mechanical responses of PVC gels in cyclic loading conditions.In this work,we combined experiments and theory to characterize the mechanical responses of two plasticized PVC gels.The gels were subjected to different types of loading-unloading-reloading cycles.The experimental results showed that the plasticized PVC gels exhibited stress softening response(the Mullins effect)in the cyclic tests.Meanwhile,the gels regained some strength after annealing at room temperature for several hours,indicating the self-healing ability of gels.We further extended the eight-chain model with incorporation of the chain dissociation and reassociation mechanism.The developed constitutive model is able to reproduce the Mullins effect and the recovery of the Mullins effect observed in the experiments.Our results clearly show that understanding the complex mechanical response is crucial for the applications of plasticized PVC gels. | Ninghan Tang Dong Lei Ji Lin Yanjie Wang Rui Xiao | 2021 | Acta Mechanica Solida Sinica2021，34，4： | 0 |
| 9 | Modeling of C_(8) Aromatics Isomerization in a Radial Bed Reactor显示文摘Reactor models were developed to describe the isomerization reaction process of C_(8) aromatics by applying a six-component sequential reaction network.Lab-scale experimental data were used in an axial bed reactor model,and dynamic parameters were fitted by simulated annealing algorithm.In addition,industrial data and calculated dynamic parameters were used to determine the six-component concentration distributions using a radial reactor model.The influence of back-mixing on reaction performance was investigated.It was found that the model considering back-mixing was much closer to the real industrial reaction process. | Gao Ninghan Tang Xiaojin Zhou Zhenhuan Xu Jian | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 10 | Association between p53 Pro72Arg polymorphism and prostate cancer risk:a meta-analysis显示文摘The tumor suppressor gene p53 appears to be important in the development of many human cancers, such as prostate cancer. The association of p53 codon72 polymorphism with prostate cancer has been widely reported; however, the results are inconsistent. To derive a more precise estimation of this relationship, we performed an updated meta-analysis from 10 case-control studies. We conducted a search in the PubMed database without a language limitation, covering all papers published until July 2010. Risk ratios (RR) with 95% confidence intervals (CIs) were used to assess the strength of the association. Ten studies including 1,196 cases and 1,704 controls were selected. Overall, no significant differences of total prostate cancer risk and p53 codon polymorphism was found (Pro/Pro vs Arg/Arg, RR = 1.12, 95%CI=0.74-1.70, P heterogeneity = 0.016, I 2 = 55.8%; Pro/Pro+Pro/Arg vs Arg/ Arg, RR = 1.05, 95%CI=1.00-1.11, P heterogeneity = 0.077, I 2 = 51.1%). In the stratified analysis by ethnicity, the same results were found. However, in the control subgroup, there was a modest decreased association between prostate cancer risk and population-based control subjects under the recessive genetic model (RR = 0.31, 95%CI=0.10-0.91, P heterogeneity = 0.110, I 2 =60.8%). This meta-analysis suggested that p53 codon Pro72Arg polymorphism could be weakly associated with prostate cancer risk. | Lifeng Zhang Ning Shao Qianqian Yu Lixin Hua Yuanyuan Mi Ninghan Feng | 2011 | The Journal of Biomedical Research2011，25，1： | 0 |
| 11 | Performance modeling of positive degraded task-pair with helper-thread in CMP显示文摘 | Gu Zhimin Zheng Ninghan Zhang Yi Liu Changding Tang Jie Huang Yan | 2010 | High Technology Letters2010，16，3： | 0 |
| 12 | Construction and identification of recombinant lentiviral vector containing HIV-1 Tat gene and its expression in 293T cells显示文摘Objective:To construct a lentiviral vector expressing HIV-1 Tat and identify its expression in 293T cells. Methods:The gene fragment of HIV-1 Tat 101 was subcloned to lentiviral transfer vector pHAGE-CMV-MCS-IZsGreen,which was named pHAGE-Tat.Then the constructed pHAGE-Tat was used to co-transfect the packing 293T cells,together with the packaging plasmids pMD2.G and psPAX2.The packaged viral particles designated LV-Tat were used to infect the 293T cells and the viral titer was calculated.The expression of HIV-1 Tat in 293T cells was confirmed using RT-PCR and western blot.Results:The recombinant lentiviral vector was successfully constructed and could express HIV-1 Tat in 293T cells.The virus titer was 5.73×106 ifu/ml.Conclusion:The successfully constructed recombinant lentiviral vector makes a strong foundation for further exploring the possible role of HIV-1 Tat in the development of prostate cancer. | Bingbing Wei Ninghan Feng Feng Zhou Chun Lu Jiantang Su Lixin Hua | 2010 | The Journal of Biomedical Research2010，24，1： | 0 |
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