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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development显示文摘The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed germination.Here we describe the Dof-like gene family in grapevine(Vitis vinifera L.),which consists of 25 genes coding for Dof.An extensive in silico characterization of the VviDofL gene family was performed.Additionally,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)analyses.The phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated genes.The diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological roles.Furthermore,distinct expression patterns were identified between samples analyzed,corroborating such hypothesis.Our expression results indicate that several VviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and production.The identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir. | Danielle Costenaro da Silva Vítor da Silveira Falavigna Marianna Fasoli Vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers | 2016 | Horticulture Research2016，3，1： | 5 |
| 3 | Subtalar dislocation without associated fractures: Case report and review of literature显示文摘Isolated subtalar dislocations are unusual injuries due to the inherent instability of the talus. Subtalar dislocations are frequently associated with fractures of the malleoli, the talus, the calcaneus or the fifth metatarsal. Four types of subtalar dislocation have been described according to the direction of the foot in relation to the talus: medial, lateral posterior and anterior. It has been shown that some of these dislocations may spontaneously reduce. A rare case of a 36-year-old male patient who sustained a closed medial subtalar dislocation without any associated fractures of the ankle is reported. The patient suffered a pure closed medial subtalar dislocation that is hardly reported in the literature. Six months after injury the patient did not report any pain, had a satisfactory range of motion, and no signs of residual instability or early posttraumatic osteoarthritis. The traumatic mechanism, the treatment options, and the importance of a stable and prompt closed reduction and early mobilization are discussed. | Dionisios Giannoulis Dimitrios V Papadopoulos Marios G Lykissas Panagiotis Koulouvaris Ioannis Gkiatas Alexandros Mavrodontidis | 2015 | World Journal of Orthopedics2015，6，3： | 4 |
| 4 | Use of intercostal nerves for different target neurotization in brachial plexus reconstruction显示文摘Intercostal nerve transfer is a valuable procedure in devastating plexopathies. Intercostal nerves are a very good choice for elbow flexion or extension and shoulder abduction when the intraplexus donor nerves are not available. The best results are obtained in obstetric brachial plexus palsy patients, when direct nerve transfer is performed within six months from the injury. Unlike the adult posttraumatic patients after median and ulnar nerve neurotization with intercostal nerves, almost all obstetric brachial plexus palsy patients achieve protective sensation in the hand and some of them achieve active wrist and finger flexion. Use in combination with proper muscles, intercostal nerve transfer can yield adequate power to the paretic upper limb. Reinnervation of native muscles(i.e., latissimus dorsi) should always be sought as they can successfully be transferred later on for further functional restoration. | Marios G Lykissas Ioannis P Kostas-Agnantis Ananstasios V Korompilias Marios D Vekris Alexandros E Beris | 2013 | World Journal of Orthopedics2013，4，3： | 2 |
| 5 | Martina and Ezio Todin Flood forecasting using a fully model : application of the TOPKAPI model to the Upper Xixian catchment显示文摘 | Liu Z Mario L V | 2005 | Hydrology and Erath System Sciences2005，9，4： | 1 |
| 6 | Printed circuit board technology inspired stretchable circuits 显示文摘 | JAN V MARIO G FREDERICK B etal | 2012 | MRS Bulletin2012，37，3： | 1 |
| 7 | Prehnite-pumpellyite ~acies metamorphism in the Cenozoic Abanico Formation,Andes of central Chile (33~50'S) :chemical and scale controls on mineral assemblages, reaction progress and the equilibrium state显示文摘 | Marcia M Luis /~ Mario V | 2010 | Andean Geology2010，37，1： | 1 |
| 8 | Comment on:American diabetes association standards of medical care indiabetes 2011 显示文摘 | Bssevi V Di Mario S Morciano C | 2011 | Diabetes Care2011，，： | 1 |
| 9 | Three dimensional shape reconstruction and finite element models to be used in clinical studies显示文摘 | Marco V Mario D Fulvia T | 2004 | J Biomech2004，37，： | 1 |
| 10 | Analytical models for FMS design optimization: a survey显示文摘 | MARIO V V | 1994 | International Journal of flexible manufacturing systems1994，6，： | 1 |
| 11 | Array-based identificationof species of the genera Abiotrophia, Enterococcus,Granulicatella, and Streptococcus 显示文摘 | Sheng K T Lee J T Mario V | 2006 | Journal of ClinicalMicrobiology2006，44，12： | 1 |
| 12 | Local search genetic algorithms for the job-shop scheduling problem 显示文摘 | Beatrice M O Mario V | 2004 | Applied Intelligence2004，21，1： | 1 |
| 13 | Susceptibility testing of fluconazole by the NCCLS broth macrodilution method, E-test, and disk diffusion for application in the routine laboratory显示文摘 | Inge V Mario V Marleen V | 2002 | J Clin Microbi2002，40，： | 1 |
| 14 | Design and validation of an ELISA for equine infectious anemia (EIA) diagnosis using synthetic peptides显示文摘 | Adriana S Veronica V Mario R | 2001 | Vet Microbiol2001，79，： | 1 |
| 15 | Susceptibility testing of fluconazole by the NCCLS broth macrodilution method,E-test,and disk diffusion for application in the routine laboratory显示文摘 | Inge V Mario V Marleen V | 2002 | J Clin Microbiol2002，，： | 1 |
| 16 | The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion:gene sharing in the lactating mammary gland 显示文摘 | Claudia V Alistair S Mario R C | 2002 | Gene Develop2002，16，： | 1 |
| 17 | RanGen: A Random Network Generator for Activity-on-the-Node Networks 显示文摘 | Erik D Mario V Willy H | 2003 | Journal of Scheduling (S1094-6136)2003，6，1： | 1 |
| 18 | Local search genetic algorithms for the job shop scheduling problem显示文摘 | Beatrice M O Mario V | 2004 | Applied Intelligence2004，21，1： | 1 |
| 19 | An Evaluation of the Adequacy of Project Network Generators with Systematically Sampled Networks 显示文摘 | Mario V Coelho J Debels D Macnhout B | 2008 | European Journal of Operational Research (S0377-2217)2008，187，2： | 1 |
| 20 | An invitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy显示文摘 | AnaP Mario V Rogerio B | 2010 | Journal of Material Science: Material in Medicine2010，21，8： | 1 |
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