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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib显示文摘 | Maria Reig Ferran Torres Carlos Rodriguez-Lope Alejandro Forner Neus LLarch Jordi Rimola Anna Darnell José Ríos Carmen Ayuso Jordi Bruix | 2014 | Journal of Hepatology2014，，： | 2 |
| 3 | Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second‐line trial design显示文摘 | Maria Reig Jordi Rimola Ferran Torres Anna Darnell Carlos Rodriguez‐Lope Alejandro Forner Neus LLarch José Ríos Carmen Ayuso Jordi Bruix | 2013 | Hepatology2013，，6： | 2 |
| 4 | Plasticity in plolycrystalline fretting fatigue contacts 显示文摘 | Goh C H McDowell D L Neu R W | 2006 | J Mech Phys Solids2006，54，： | 1 |
| 5 | Transversely isotropic viscoplasticity model for a directionally solidified Ni-base superalloy显示文摘 | Shenoy M M McDowell D L Neu R W | 2006 | International Journal of Plasticity2006，22，12： | 1 |
| 6 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 7 | A technique for analysisofutilization-availability data显示文摘 | Neu C W Byers C R Peek J M | | 0，，03： | 1 |
| 8 | Determination of stavudine in human plasma and urine by high- performance liquid chromatography using a reduced sample volume显示文摘 | Marya S Neus R Laura Z | 2000 | J Chromatogr B2000，746，： | 1 |
| 9 | Evaluation of Ciba Coming ACS:180TM automated immunoassay system显示文摘 | Josefina M B Neus G R | 1994 | Clin Chem1994，40，3： | 1 |
| 10 | A technique for analysis of utilization availability data显示文摘 | NEU C W BYERS C R PEEK J M | 1974 | wildl Manage1974，38，3： | 1 |
| 11 | 显示文摘 | Neu R T | 1996 | Microbiol Rev1996，60，： | 1 |
| 12 | A simple roating annular reactor for replicated biofilm studies 显示文摘 | Lawrence J R Swerhone G D W Neu T R | 2000 | J Microbiol Methods2000，42，： | 1 |
| 13 | Oxygen profiles and biomass distribution in biopellets of Aspergillus niger 显示文摘 | Hill A Neu T R Hempel D C | 2005 | Biotechnol Bioeng2005，92，： | 1 |
| 14 | Fretting fatigue damage accumulation in PH13-8Mo stainless steel显示文摘 | Pape J A Neu R W | 2001 | International Journal of Fatigue2001，23，： | 1 |
| 15 | Combination of sildenafil and bosentan for pulmonary hypertension in a human ex vivo model 显示文摘 | Ried M1 Potzger T Neu R | 2014 | Cardiovasc Drugs Ther2014，28，1： | 1 |
| 16 | Microbial extracellular polymeric substances: characterization, structure, and function 显示文摘 | Wingender J Neu T R Flemming H-C | 1999 | Springer Science and Business Media1999，，： | 1 |
| 17 | A simple rotating annular reactor for replicated biofilm studies 显示文摘 | Lawrence J R Swerhone G D W Neu T R | 2000 | J Microbiological Methods2000，42，： | 1 |
| 18 | Performance and microbial structure of a nitrifying fluidized-bed reactor显示文摘 | Kloep F Rske I Neu T R | 2000 | Water Research2000，34，： | 1 |
| 19 | Interaction between biofilm development, structure and detachment in rotating annular reactors 显示文摘 | Gamy K Horn H Neu T R | 2008 | Bioprocess Biosyst Eng2008，31，6： | 1 |
| 20 | The developing intestinal mi- crobiome and its relationship to health and disease in the neonate显示文摘 | Murgas Torrazza R Neu J | 2011 | J Perinatol2011，31，1： | 1 |
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