|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 3 | Helieobaeter Pylori induces apoptosis of rat gastric parletal cells 显示文摘 | Neu B Randlkofer P Neuhofer M | 2002 | Am J Physiol Gastrointest Liver Physiol2002，283，2： | 1 |
| 4 | Transversely isotropic viscoplasticity model for a directionally solidified Ni-base superalloy显示文摘 | Shenoy M M McDowell D L Neu R W | 2006 | International Journal of Plasticity2006，22，12： | 1 |
| 5 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 6 | Inhibition of sporulation,glycopetide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15 009 by protein kinase inhibitors 显示文摘 | Neu J M Wright G D | 2001 | FEMS Mierobiol Lett2001，199，1： | 1 |
| 7 | Cognitive function over the treatment course of depression in middle-age pailents:correlation with brain Mri signal hyperintensities显示文摘 | Neu P Bajbouj M Schilling A | 2005 | J psychiatr Res2005，39，2： | 1 |
| 8 | Intestinal microbial ecology in premature infants assessed with non-culturebased techniques显示文摘 | Mshvildadze M Neu J Shuster J | 2010 | J Pediatr2010，156，1： | 1 |
| 9 | A technique for analysisofutilization-availability data显示文摘 | Neu C W Byers C R Peek J M | | 0，，03： | 1 |
| 10 | Evaluation of Ciba Coming ACS:180TM automated immunoassay system显示文摘 | Josefina M B Neus G R | 1994 | Clin Chem1994，40，3： | 1 |
| 11 | A technique for analysis of utilization availability data显示文摘 | NEU C W BYERS C R PEEK J M | 1974 | wildl Manage1974，38，3： | 1 |
| 12 | Recent advances in rational gene transfer vector design, based on poly(ethylene imine) and its derivatives显示文摘 | Neu M Fischer D Kissel T | 2005 | J Gene Medicine2005，7，8： | 1 |
| 13 | Recent advances in rational gene transfer vector design based on poly (ethylene imine) and its derivatives 显示文摘 | Neu M Fischer D Kissel T | 2005 | Journal of Gene Medicine2005，7，： | 1 |
| 14 | Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI显示文摘 | Kleemann E Neu M Jekel N | 2005 | J Control Rel2005，109，13： | 1 |
| 15 | Cognitive function over the treatment course of depression in middle-aged patients:correlation with brain MRI signal hyperintensities显示文摘 | Neu P Bajbouj M Schilling A | | 0，，： | 1 |
| 16 | Postnatal nutrition and adult health proramming显示文摘 | Neu J Hauser N Douglas-Escobar M | 2007 | Sem in Fetal Neonatal Meal2007，12，1： | 1 |
| 17 | Ablation of the trabecular meshwork显示文摘 | Vogel M Scheurer G Neu W | 1990 | Klin Monatsbl Augenheilkd1990，197，3： | 1 |
| 18 | Effects of dietary additives(potassium diformate/organic acids)as well as influences of grinding intensity(coarse/fine)of diets for weaned piglets experimentally infected with Salmonella Derby or Escherichia coli显示文摘 | Taube V A Neu M E Hassan Y | 2009 | J Anim Physiol Anim Nutr(Berl)2009，93，3： | 1 |
| 19 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lü uddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 20 | Probioties and prevention of necrotizing enterocolities 显示文摘 | Mshvildadze M Neu J | 2009 | Early Hum Dev2009，85，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员