|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner显示文摘 | Neta Erez Morgan Truitt Peter Olson Douglas Hanahan | 2010 | Cancer Cell2010，，2： | 4 |
| 2 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 3 | Heparanase: busy at the cell surface显示文摘 | Liat Fux Neta Ilan Ralph D. Sanderson Israel Vlodavsky | 2009 | Trends in Biochemical Sciences2009，，10： | 3 |
| 4 | Significance of Heparanase in Cancer and Inflammation显示文摘 | Israel Vlodavsky Phillip Beckhove Immanuel Lerner Claudio Pisano Amichai Meirovitz Neta Ilan Michael Elkin | 2012 | Cancer Microenvironment2012，，2： | 2 |
| 5 | Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA antibodies from low-affinity precursors显示文摘 | Yachimovich-Cohen Ruth F Neta B | 2003 | Eur J Immunol2003，33，9： | 1 |
| 6 | Rate constants for reactions of SO4^- radicals in acetonitrile 显示文摘 | Padmaja S Z B Neta P Huie R E | 1993 | International Journal of Chemical Kinetics1993，25，3： | 1 |
| 7 | Rate constants for reactions of nitrogen oxide radicals in aqueous solutions显示文摘 | Neta P Huie R E 1986 | 1986 | J Phys Chem1986，90，19： | 1 |
| 8 | Mechanisms of ionizing radiation-induced destruction of 2, 6-dichlorobiphenyl in aqueous solutions 显示文摘 | Sheikhly M A Silwerman J Neta P | 1997 | Environmental Science and Technology1997，31，9： | 1 |
| 9 | Common genetic variants in metabolism and detoxification pathways and the risk of papil- lary thyroid cancer显示文摘 | Aschebrook- Kilfoy B Neta G Brenner AV | 2012 | Endocr Relat Cancer2012，19，： | 1 |
| 10 | Prevention and treatment: summary statememt 显示文摘 | Fry SA Neta R Weiss JF | 2002 | Mil Med2002，167，1： | 1 |
| 11 | Dual role for tomato HSP21: protecting photosystem II from oxidative stress and promoting col- or changes during fruit maturation 显示文摘 | Neta S I Isaacson T Lurie S | 2005 | The Plant Cell2005，17，： | 1 |
| 12 | Mechanisms of ionizing radiation-induced destruction of 2,6-dichloro- biphenyl in aqueous solutions 显示文摘 | Sheikhly M A Silwerman J Neta P | 1997 | Environ Sci Technol1997，31，9： | 1 |
| 13 | L-12 protects bone marrow from and sensitizes intestinal tract to ionizing显示文摘 | Neta R Stiefel SM Finkelman F | | 0，，09： | 1 |
| 14 | View-dependent rendering on large polygonal models over networks显示文摘 | Jihad El-Sana Neta Sokolovsky | | 0，，02： | 1 |
| 15 | Electron-Transfer Reactions between C60 and Radical Ions of Metalloporphyrins and Arenes显示文摘 | Dirk M Guldi Pedatsur Neta Klaus-Dieter Asmus | 1994 | J Phys Chem1994，98，17： | 1 |
| 16 | Reaction kinetics in ionic liquids as studied by pulseradiolysis: Redox reactions in the solvents methyltributylammoniumbis(trifluoromethylsulfonyl)imide and iV-butylpyridinium tetrafluoroborate显示文摘 | Behar D Neta P | 2002 | Journal of Physical Chemistry A2002，106，13： | 1 |
| 17 | Rate constants for reactions of inorganic radicals in aqueous solution 显示文摘 | Neta P Huie R E | 1988 | J Phys Chem Ref Data1988，17，3： | 1 |
| 18 | Pathogenesis of bovine brucellosis显示文摘 | CARVALHO NETA A V MOL J P XAVIER M N | 2010 | Vet J2010，184，2： | 1 |
| 19 | Establishment and initial characterization of the ovine mammary epithelial cell line nish 显示文摘 | NETA ILAN ITAMAR BARASH ELISHA GOOTWINE | 1998 | In Vitro Cell1998，34，4： | 1 |
| 20 | Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species : a special emphasis on mech- anisms of action on Candida tropicalis显示文摘 | Neto J B da Silva C R Neta M A | 2014 | PLoS ONE2014，9，93： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员