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| 1 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 2 | Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats显示文摘Objective:To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa(C. verrucosa) in rats.Methods:Three wound models including incision,excision and dead space wounds were used in this study.The parameters studied were breaking strength in incision models,granulation tissue dry weight,breaking strength and hydroxyproline content in dead space wounds,percentage of wound contraction and period of epithelialization in excision wound model.Results:Two doses of the extract with and without dexamethasone showed significant increases in mean hydroxyproline,total protein content and dry weight of granulation tissue but it was higher with dose 800 mg/kg comparing with the control.The dexamethasone treated group showed a significant(P<0.001) reduction in the wound breaking strength when compared to control group in incision type of wound model.Coadministration of C.verrucosa with dexamethasone significantly(P<0.001) increased the breaking strength compared to the dexamethasone treated only group.In excision wound model,the percentage of the wound contraction was significantly(P<0.01) increased by two doses of test extract on all the days except the lower dose which exhibited only on 12th,16th days of drug treatment and it also reversed the dexamethasone suppressed wound contraction.It significantly(P<0.001) reduced the time required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P<0.001).Conclusions:C.verrucosa was found to possess significant wound healing property. This was evident by decrease in the period of epithelialization,increase in the rate of wound contraction,skin breaking strength,and granulation tissue dry weight content.Hence C. verrucosa could be a good wound healing agent. | Meena Kumari Eesha BR Mohanbabu Amberkar Sarath babu Rajshekar Neelesh Kumar | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 3 |
| 3 | 吸入型糖皮质激素用于哮喘患者的效果研究显示文摘目的借助于哮喘控制测试(ACT),论证使用吸入型糖皮质激素作为控制哮喘患者病情的临床疗效,与未使用任何药物控制哮喘症状或疾病发作的患者进行数据比较。方法在2012年7月,总共60名哮喘患者被要求做ACT问卷,其中32名患者作为对照组(n=32)未使用任何控制药物;28名患者作为观察组(n=28)使用吸入型糖皮质激素;并对两组的ACT结果进行了比较。结果所有患者都进行了ACT,并得到了相应的ACT分值。在对照组中,所有男性(n=13)患者的哮喘病情都控制不佳,19名女性中只有2名(10.53%)患者的病情得到了轻微的控制,其余的17名女性患者(89.47%)哮喘病情都控制不佳。在观察组中,男性患者(n=13)有6名(46.15%)患者哮喘病情未得到控制,女性患者(n=15)中,只有3名(20%)患者哮喘病情未得到控制。总体来说,ACT分值高于19的情况下,11名(39.29%)患者的哮喘得到了良好控制。结论使用吸入型糖皮质激素的哮喘控制物,例如倍氯米松和去炎松在维持哮喘的良好控制方面取得较好结果 ,ACT分值结果展示了这一点。使用吸入型糖皮质激素与未使用任何控制物相比,ACT分值得到了显著改变。 | Bhanu Siva Kumar Sileveru Dinesh Babu Abbadasari Neelesh Taticherala 冯宇峰 | 2013 | 中国实用医药2013，8，29： | 3 |
| 4 | Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer显示文摘 | Neelesh Sharma Nathan Pennell Myles Nickolich Balazs Halmos Patrick Ma Tarek Mekhail Pingfu Fu Afshin Dowlati | 2014 | Investigational New Drugs2014，，2： | 2 |
| 5 | Mimicking the lotus effect:Influence of double roughness strucures and slender peillars显示文摘 | NEELESH A PATANKAR | 2004 | Langmuir2004，20，： | 1 |
| 6 | Electrical characterization of PVA-based nanocomposite electrolyte nanofibre mats doped with a multiwalled carbon nanotube显示文摘 | S. L. Agrawal Neelesh Rai T. S. Natarajan Navin Chand | 2013 | Ionics2013，，1： | 1 |
| 7 | Production of α‐amylase with Aspergillus flavus on Amaranthus grains by solid‐state fermentation显示文摘 | PoornaViswanathan Neelesh R.Surlikar | 2001 | J Basic Microbiol2001，，1： | 1 |
| 8 | Mimicking the lotus effect influence of double roughness structures and slender pillars显示文摘 | Neelesh A Patankar | 2004 | Langmuir2004，20，19： | 1 |
| 9 | Use of pharmacy delivery robots in intensive care units显示文摘 | Marc R. Summerfield F. Jacob Seagull Neelesh Vaidya Yan Xiao | 2011 | American Journal of Health-System Pharmacy2011，，1： | 1 |
| 10 | Epidermal growth factor receptor ( EGFR) - targeted therapies in esophagogastric cancer显示文摘 | Sabarish A Dhivya P Neelesh S | 2013 | Anticancer Research2013，33，1： | 1 |
| 11 | Optimization of process pa- rameters of mechanical type advancedmachining processes using ge- netic algorithms 显示文摘 | Neelesh K Jain V K Jain Kalyanmoy | 2007 | International Journal of Machine Tools and Manufacture2007，47，6： | 1 |
| 12 | Bioactive compounds from natural resources against skin aging显示文摘 | Pulok K M Niladri M Neelesh K N | 2011 | Phytomedicine2011，19，1： | 1 |
| 13 | Contact angle hysteresis on rough hydrophobic surfaces显示文摘 | BO H JUNGHOON L NEELESH A P | 2004 | Colloids and Surfaces A: Physicochem Eng Aspects2004，248，： | 1 |
| 14 | Oxidative and Photooxidative Degradation of Poly (acryfic acid) 显示文摘 | Neelesh Bharti Shukla | 2009 | Polymer Degradation and Stability2009，，94： | 1 |
| 15 | Complete recovery of acute monocular visual loss following endoscopic resection of anterior clinoid mucocele: Case report and review of the literature显示文摘 | Neelesh Nundkumar Monika Mittal William J. Kupsky Adam Folbe Sandeep Mittal | 2011 | Journal of the Neurological Sciences2011，，： | 1 |
| 16 | Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity显示文摘 | Niladri Maity Neelesh K. Nema Md. Karim Abedy Birendra K. Sarkar Pulok K. Mukherjee | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 17 | Aquatic manoeuvering with counter-propagating waves: a novel locomotive strategy显示文摘 | Oscar M. Curet Neelesh A. Patankar George V. Lauder Malcolm A. MacIver | 2011 | Journal of the Royal Society Interface2011，，60： | 1 |
| 18 | numerical simulation of electroosmotic flow显示文摘 | Neelesh A Patanka r Howard H Hu | 1998 | Anal Chem1998，70，： | 1 |
| 19 | The immersed molecular finite element method显示文摘 | Kopacz Adrian M Patankar Neelesh A Liu Wing K | 2012 | Computer Methods in Applied Mechanics and Engineering2012，23，： | 1 |
| 20 | 显示文摘 | Lee Junghoon He Bo Patankar Neelesh A | 2005 | Journal of Micromechanics and Micromengineering2005，15，3： | 1 |
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