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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Impact of tree diversity and environmental conditions on the survival of shrub species in a forest biodiversity experiment in subtropical China显示文摘Aims Although shrubs are an important component of forests,their role has not yet been considered in forest biodiversity experiments.In the biodiversity-ecosystem functioning(BEF)experiment with subtropical tree species in south-east China(BEF-China),we factorially combined tree with shrub species-diversity treatments.Here,we tested the hypotheses that shrub survival differs between the 10 planted shrub species,with lower survival rates of late-than early-successional species and is affected by environmental conditions,such as topography and top soil characteristics,as well as by biotic factors,represented by tree,shrub and herb layer characteristics.Methods We analyzed the survival of 42000 shrub individuals in 105 plots varying in tree and shrub species richness of the BEF-China project four years after planting.Shrub survival was analyzed with generalized linear mixed effects models at the level of individuals and with variance partitioning at the plot level.Random intercept and random slope models of different explanatory variables were compared with respect to the Bayesian Information Criterion(BIC).Important Findings Survival rates differed largely between the 10 shrub species,ranging from 26%to 91%for Ardisia crenata and Distylium buxifolium,respectively.Irrespective of species identity,single abiotic factors explained up to 5%of species survival,with a negative effect of altitude and slope inclination and a positive effect of the topsoil carbon to nitrogen ratio,which pointed to drought as the major cause of shrub mortality.In contrast,neither tree nor shrub richness affected shrub survival at this early stage of the experiment.Among the biotic predictors,only herb layer species richness and cover of the dominant fern species(Dicranopteris pedata)affected shrub survival.Overall,our models that included all variables could explain about 65%in shrub survival,with environmental variables being most influential,followed by shrub species identity,while tree species diversity(species richness and identity)and herb layer characteristics contributed much less.Thus,in this early stage of the experiment the biotic interactions among shrubs and between shrubs and trees have not yet overruled the impact of abiotic environmental factors. | Bo Yang Ying Li Bingyang Ding Sabine Both Alexandra Erfmeier Werner Härdtle Keping Ma Bernhard Schmid Thomas Scholten Gunnar Seidler Goddert von Oheimb Xuefei Yang Helge Bruelheide | 2017 | Journal of Plant Ecology2017，10，1： | 7 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 5 | Human biological monitoring of suspected .ndocrine-disrupting compounds显示文摘内分泌破坏的混合物是防碍身体的自然荷尔蒙的外长的代理人。人的生物监视是为监视暴露到内分泌的破坏混合物的一个强大的方法。在这评论,我们为内分泌的破坏混合物, polychlorinated 联本基, brominated 火焰 retardants, phthalates, alkylphenols,杀虫剂,金属, perfluronated 混合物, parabens,紫外过滤器,和器官的溶剂的不同的组描述人的生物监视系统。讨论的方面是到暴露,新陈代谢,分析的矩阵,分析决心方法,决定因素,和时间趋势的起源。 | Moosa Faniband Christian H Lindh Bo AG Jfnsson | 2014 | Asian Journal of Andrology2014，16，1： | 3 |
| 6 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 7 | Optimization of hot gas chamber in high temperature reactor显示文摘 | WANG J BO H JIANG S | 2004 | J Nucl Sci Technol2004，11，： | 1 |
| 8 | Evidence- based guideline update: Plasmapheresis in neurologic disorders 显示文摘 | Khatri BO McQuillen MP Kaminski H | 2011 | Neurology2011，77，： | 1 |
| 9 | Improved Prandial Glucose Control With Lower Risk of Hypoglycemia With Nateglinide Than With Glibenclamide in Patients With Maturity - Onset Diabetes of the Young Type 3显示文摘 | Tiinamaija T Elina H H BO I | 2006 | Diabetes Care2006，29，2： | 1 |
| 10 | A modified Anderson-Wilkins electrocardiographic acuteness score for anterior or inferior myocardial infarction显示文摘 | Bo H Rasmus R Eva P | 2003 | Am Heart J2003，146，5： | 1 |
| 11 | Effects of osthole on apoptosis and TGF-bl of hypertrophic scar fibroblasts 显示文摘 | Xiaohua H Bo C Hongqi L | 2009 | J Asian Natural Products Res2009，11，7： | 1 |
| 12 | Evi- dence-based guideline update: Plasmapheresis in neurologic disorders 显示文摘 | Khatri BO McQuillen MP Kaminski H | 2011 | Neurology2011，77，17： | 1 |
| 13 | Intracortical multiplesclerosis lesions are not associatecd with increased lymphocyteinfiltration显示文摘 | Bo L Vedeler C A Nyland H | 2003 | Mult Scler2003，9，4： | 1 |
| 14 | 显示文摘 | Langenhove H V Pruuost P | 2003 | J Membr Sci2003，215，12： | 1 |
| 15 | Co administration of metformin during rFSH treatment in patients with clomiphene citrate resistant polycystic ovarian syndrome :a prospective randomized trial显示文摘 | Yarali H Yildiz BO Demirol A | 2002 | Hum Reprod2002，17，2： | 1 |
| 16 | Spatial and temporal variation of historical anthropogenic NMVOCs emission inventories in China 显示文摘 | Bo Y Cai H Xie S D | 2008 | Atmespheric Chemistry and physics2008，8，11： | 1 |
| 17 | Expression of inflammationrelated genes in endothelial cells is not directly affected by microparticles from preeclamptic patients显示文摘 | Lok C A Boing A N Reitsma P H | 2006 | J Lab Clin Med2006，147，6： | 1 |
| 18 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 19 | Different temperature optima formation when enrichments from acid peat are supplemented with acetate of pydrogen显示文摘 | Svensson Bo H | 1984 | A Environ Microbiol1984，48，2： | 1 |
| 20 | c-Fos,N-methyl-d-aspartate receptor 2C,GABA-A-alphal immonore-activity,seizure latency and neuronal injury following single or recurrent neonatal seizures in hipocampus of Wistar rat显示文摘 | Ni H Jiang Y W Bo T | 2005 | Neurosci Lett2005，380，12： | 1 |
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