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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Inhibition of angiotensin-converting enzyme by synthetic peptides of human β-casein 显示文摘 | Kohmura M Nio N Kubo K | 1989 | Agricultural and Biological Chemistry1989，53，8： | 1 |
| 5 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 6 | A randomized consent design trial of neoadjuvant chemotherapy with tegafur plus uracil (UFF) for gastric cancer---a single institute study 显示文摘 | Nio Y Koike M Omori H | 2004 | Anticancer Res2004，24，3： | 1 |
| 7 | High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-liKe disorders显示文摘 | Nio Y Iguchi C Itakura M | 2009 | Anticancer Research2009，29，5： | 1 |
| 8 | Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients显示文摘 | Song M M Nio Y Dong M Tamura K Furuse K Tian Y L | 2000 | J Surg Oneol2000，75，： | 1 |
| 9 | Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation显示文摘 | Yamashita T Honda M Nio K | 2010 | Cancer Res2010，70，11： | 1 |
| 10 | Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders显示文摘 | Prior R L Fan E Ji H P Howell A Nio C Payne M J Reed J | 2010 | Journal of the Science of Food and Agriculture2010，90，9： | 1 |
| 11 | Inhibition of angiotensin-converting enzyme by synthetic peptides of human β-casein显示文摘 | Kohmura M Nio N Kubo K | 1989 | Agric Biol Chem1989，53，： | 1 |
| 12 | Premature acute myocardial infarction in a child with nephrotic syndrome显示文摘 | José M. P. Silva Eduardo A. Oliveira Viviane S. P. Marino José S. Oliveira Rosália M. Torres Ant?nio L. P. Ribeiro Carlos J. R. Simal Mário C. A. Ribeiro | 2002 | Pediatric Nephrology2002，，3： | 1 |
| 13 | Some characteristics of a microbial protein cross-linking enzyme: transglutaminase 显示文摘 | Seguro K Nio N Motoki M | 1996 | ACS Syrup Ser1996，650，： | 1 |
| 14 | Stealth Optimized Fisheye State Routing in Mobile Ad-Hoc Networks Using Directional Antennas显示文摘 | ANT(O)NIO G MARIO M PEDRO S | 2005 | IEEE2005，，04： | 1 |
| 15 | Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer显示文摘 | Yamasawa K Nio Y Dong M | 2002 | Clin Cancer Res2002，8，8： | 1 |
| 16 | Heat-induced colour changes of pine (Pinus pinaster) and euealypt (Eu- calyptus globulus) wood 显示文摘 | Bruno M Esteves Anto'nio Velez Marques Idalina Domingos | 2008 | Wood Science and Technology2008，42，： | 1 |
| 17 | Gelation mechanism of protein solution by transglutaminase显示文摘 | Nio N Motoki M & Takinami K | 1986 | Agricultural and Biological Chemistry1986，50，： | 1 |
| 18 | Inhibition of angio tensin-converting enzyme by synthetic peptides of human β -casein显示文摘 | Kohmura M Nio N Kubo K | 1989 | Agric Biol Chem1989，53，8： | 1 |
| 19 | Five-and 10-year survival rates after surgery for biliary atresia: a report from the Japanese Bili- ary Atresia Registry 显示文摘 | Nio M Ohi R Miyano T | 2003 | J Pediatr Surg2003，38，7： | 1 |
| 20 | Inhibition of angito-tensin con- vetting enzyme by synthetic peptides of human B-casein显示文摘 | KOHMURA M NIO N KUBO K | 1989 | Agric Biol Chem1989，53，8： | 1 |
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