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| 1 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice显示文摘Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles(NFTs); these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone(TIB) have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB(0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated Tau(PHF-1) proteins and the regulation of GSK3β/Akt/PI3 K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3 K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB: it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3 K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes. | Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian Guerra-Araiza | 2017 | Neural Regeneration Research2017，12，4： | 12 |
| 2 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 3 | Large gangliocytic paraganglioma of the duodenum:A rare entity显示文摘Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. | Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 4 | Simulation of transpiration, drainage, N uptake, nitrate leaching, and N uptake concentration in tomato grown in open substrate显示文摘 | M. Gallardo R.B. Thompson J.S. Rodríguez F. Rodríguez M.D. Fernández J.A. Sánchez J.J. Magán | 2009 | Agricultural Water Management2009，，12： | 2 |
| 5 | RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement. | Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 7 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | José Antonio Alburquerque Pablo Salazar Vidal Barrón José Torrent María del Carmen del Campillo Antonio Gallardo Rafael Villar | 2013 | Agronomy for Sustainable Development2013，，3： | 2 |
| 8 | Second order differential operators with integral boundary conditions and generation of semigroups 显示文摘 | Gallardo J M | 2000 | Rocky Mt J Math2000，30，： | 1 |
| 9 | P70 S6 kinase activation is not required for insulin-like growth factor induced differentiation of rat,mouse or human skeletal muscle cells 显示文摘 | Canicio J Gallardo E llla E | 1998 | Endocrinology1998，139，： | 1 |
| 10 | A Model of Strategic Change:Universities and Dynamic Capabilities显示文摘 | Jose Ruiz Navarro Francisca Orihuela Gallardo | 2003 | Higher Education Poficy2003，，16： | 1 |
| 11 | Effect of age on sperm fertility potential:oocyte donation as a model显示文摘 | Gallardo E Simon C Levy M | 1996 | Fertil Steril1996，66，2： | 1 |
| 12 | Biological soil crusts modulate nitrogen availability insemi-arid ecosystems: Insights from a Mediterraneangrassland显示文摘 | Castillo MAP Maestre FT Delgado BM Gallardo A | 2010 | Plant and Soil2010，333，1： | 1 |
| 13 | An alternative route to the consolidation of mechanically alloyed aluminum powder显示文摘 | RODRIGUEZ J A GALLARDO J M HERRERA E J | 1995 | Materials Transactions1995，36，2： | 1 |
| 14 | Proteomic evalu- ation of myofibrillar carbonylation in chilled fish mince and its inhibi- tion by catechin显示文摘 | PAZOS M MAESTRE R GALLARDO J M | 2013 | Food Chemistry2013，136，： | 1 |
| 15 | Increased SNAIL ex- pression and low syndecan levels are associated with high Glea- son grade in prostate cancer显示文摘 | Pohlete CE Fulla J Gallardo M | 2014 | Int J Oncol2014，44，3： | 1 |
| 16 | Temporal variation in total leaf phenolics concentration of Quercus robur in forested and harvested stands in northwestern Spain显示文摘 | Covelo F Gallardo A | 2001 | Canadian Journal of Botany2001，79，11： | 1 |
| 17 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 18 | Effect of different agricultural management systems on chemical fertility in culiivated tepetates of the Mexican transvolcanic belt 显示文摘 | Sara Covaleda Silvia Pajares Juan F Gallardo | 2009 | Agriculture Ecosystems and Environment2009，129，： | 1 |
| 19 | Proteomlc analysis of Arabidopsis seed germination and priming 显示文摘 | Gallardo K Job C Groot S P C | 2001 | Plant Physiol2001，126，： | 1 |
| 20 | DSP-based doubly fed induction generator test bench using a back-to-back PWM converter 显示文摘 | Gallardo S Carrasco J M Galwan | 2004 | IEEE on Industrial Electronics Society2004，，2： | 1 |
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