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| 1 | Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus显示文摘BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care units.ABC strains can develop resistance to all the antibiotics available.Carbapenem resistance is common and colistin resistance is rare in our country.Knowing the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our country.AIM To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter sp.Strains.METHODS During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included retrospectively.Continuous variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant strains.RESULTS High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter sp.Different combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant strains.Although the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two groups.Among the patients with infections due to colistin-resistant strains,seven were treated with antibiotic combinations that included sulbactam.Clinical(6/7)and microbiological(5/7)response rates were quite high in these patients.CONCLUSION The optimal therapy regimen is unclear for colistin-resistant Acinetobacter sp.infections.Although combinations with sulbactam seems to be more effective in our study patients,data supporting the usefulness of combinations with sulbactam is very limited. | Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk | 2019 | World Journal of Clinical Cases2019，7，10： | 7 |
| 2 | 采用锰矿从水溶液中吸附铅和镉离子(英文)显示文摘采用低成本的本地可得的天然锰矿作为吸附剂,研究吸附工艺从水溶液中脱除铅离子和镉离子。利用伪一级、伪二级动力学和颗粒内扩散模型检验动力学吸附数据,计算和比较这些动力学模型的吸附速率常数,发现用伪二级动力学模型能最佳地描述吸附动力学。将 Langmuir 和 Freundlich 等温吸附模型用来拟合不同温度下的平衡数据,发现实验数据与 Langmuir 模型拟合得更好。采用 Langmuir 等温吸附模型计算出锰矿吸附铅离子和镉离子的最大容量分别为 98 和 6.8 mg/g。计算了热力学参数,如吸附吉布斯自由能的变化、焓变与熵变。结果表明,锰矿作为吸附剂对铅和镉的吸附反应是自发的吸热反应。因此,锰矿作为一种天然的矿物吸附剂,可以替代现有的吸附剂来脱除水溶液中的铅离子和镉离子。 | Aylin SNMEZAY M.SALIM NCEL Nihal BEKTAS | 2012 | Transactions of Nonferrous Metals Society of China2012，22，12： | 6 |
| 3 | Diabetes-induced changes in cardiac voltage-gated ion channels显示文摘Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune response.Furthermore,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery disease.As DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart failure.Electrophysiological changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus patients.In recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic heart.In addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic patients.There are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its progress.In this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM. | Nihal Ozturk Serkan Uslu Semir Ozdemir | 2021 | World Journal of Diabetes2021，12，1： | 6 |
| 4 | Evaluation of CA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 是在通过手术高的风险,或不能实行的病人的最低限度地侵略的、新兴的治疗。为风险分类使用的参数在病人的选择有一些缺乏。学习是在糖类抗原 125 上评估 TAVI 的影响的这的目的(CA125 ) 和 N 终端职业人员大脑类型 Natriuretic 肽(NT-proBNP ) 作为在最近的年里经常被使用了的 biomarkers,并且也到 prognosis.Methods & 的这些 biomarkers 的关系;ResultsTranscatheter 大动脉的阀门培植在这研究在 31 个病人上被练习。然后,在病人学习在以前并且在 TAVI 以后的 CA125 和 NT-proBNP 层次被评估。病人也根据他们的左室的喷射部分(LVEF ) 被组织, CA125 铺平(LVEF ≥40% 并且 <40% ;CA125 ≤35 U/L 和 >35 U/L ) 。TAVI 手术成功地在所有病人被动。没有在里面医院死亡,在功能的能力的实质的改进在跟帖被检测。另外,统计上重要的减少在所有病人的 post-TAVI CA125 和 NT-proBNP 层次被检测(CA125 83.8 ±18.1 U/L 对 64.3 ±14.2 U/L, P = 0.008;NT-proBNP:4633.6 ±627.6 pg/mL 对 2866.3 ±536.8 pg/mL, P <0.001 ) 。在根据 CA125 层次划分的组,也在 CA125 层次有统计上重要的 post-TAVI 衰落。在 CA125 > 以内;35 U/L 和 LVEF <40% 组,对一个心律调整器的永久需要在(3.2%) 被要求病人和死亡在二被观察(6.4%) 在 TAVI 在以后的病人跟随 TAVI 能与 CA125 和 NT-proBNP 的高基线层次在病人有效地并且可靠地被执行的 up.ConclusionsThe 结果表演。当高 biomarker 层次与不希望得到的事件被联系时,这些 biomarkers 与 TAVI 实质地被减少,并且当然,这些 biomarkers 能为 TAVI 在耐心的选择被用于风险分类。 | Huseyin Ayhan Haca Ahmet Kasapkara Tahir Durmaz Telat Keles Cenk San Serdal Bastug Kemal Esref Erdogan Nihal Akar Bayram Emine Bilen Murat Akgay Engin Bozkurt | 2015 | Journal of Geriatric Cardiology2015，12，2： | 5 |
| 5 | Can platelet count/spleen diameter ratio be used for cirrhotic children to predict esophageal varices?显示文摘AIM To determine the laboratory and radiologic parameters, including the platelet count(PC)-to-spleen diameter(SD) ratio as a non-invasive marker that may predict the presence of esophageal varices(EV) in children with cirrhosis.METHODS Eighty-nine patients with cirrhosis, but without a history of variceal bleeding were prospectively included. The children were grouped into 6-12 and 12-18 years of age groups. These groups were also divided into 2 subgroups(presence and absence of EV). All of the patients underwent a complete biochemical and radiologic evaluation. The PC(n/mm^3)-to-SD(mm) ratio was calculated for each patient. RESULTS Sixty-nine of 98(70.4%) patients had EV. The presence of ascites in all age groups was significantly associatedwith the presence of EV. There were no differences in serum albumin levels, PC, SD and the PC-to-SD ratio between the presence and absence of EV groups in both age groups(P > 0.05). CONCLUSION Laboratory and radiologic parameters, including the PC-to-SD ratio as a non-invasive marker(except for the presence of ascites), was inappropriate for detecting EV in children with cirrhosis. | Oya Balci Sezer Deniz Celik Nihal Tutar Figen Ozcay | 2016 | World Journal of Hepatology2016，8，33： | 4 |
| 6 | A New Characterization of Transformations by the Use of Apollonius Points of (2n-1)-gons显示文摘在这篇论文,我们给 Mobius 转变的新描述。Todo 这,我们扩大一个三角形并且一个五边形的 Apollonius 点的观点,到观点, ofApollonius 指向一任意(2n-1 )-gon。 | Serap BULUT Nihal YILMAZ Department of Mathematics Faculty of Arts and Science Balikesir University Balikesir 10100 Turkey | 2005 | Acta Mathematica Sinica,English Series2005，21，3： | 3 |
| 7 | Trace elements in diabetic cardiomyopathy:An electrophysiological overview显示文摘There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and mortality throughout the world.Recent clinical and experimental studies have extensively demonstrated that this cardiomyopathy causes impaired cardiac performance manifested by early diastolic and late systolic dysfunction.This impaired cardiac performance most probably have emerged upon the expression and activity of regulatory proteins such as Na+/Ca2+exchanger,sarcoplasmic reticulum Ca2+-ATPase,ryanodine receptor and phospholamban.Over years many therapeutic strategies have been recommended for treatment of diabetic cardiomyopathy.Lately,inorganic elements have been suggested to have anti-diabetic effects due to their suggested ability to regulate glucose homeostasis,reduce oxidative stress or suppress phosphatases.Recent findings have shown that trace elements exert many biological effects including insulin-mimetic or antioxidant activity and in this manner they have been recommended as potential candidates for treatment of diabetes-induced cardiac complications,an effect based on their modes of action.Some of these trace elements are known to play an essential role as component of enzymes and thus modulate the organ function in physiological and pathological conditions.Besides,they can also manipulate redox state of the channels via antioxidant properties and thus contribute to the regulation of [Ca2+]i homeostasis and cardiac ion channels.On account of little information about some trace elements,we discussed the effect of vanadium,selenium,zinc and tungstate on diabetic heart complications. | Nihal Ozturk Yusuf Olgar Semir Ozdemir | 2013 | World Journal of Diabetes2013，4，4： | 2 |
| 8 | The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor显示文摘Dear Editor,Essential tremor(ET)is one of the most common movement disorders of unknown etiology[1,2],having an overall prevalence of 4%in the general population[2].The age at onset has been reported to be between 15 years and 20 years,and penetrance to be complete at between50 years and 70 years.It seems to be a progressive neurological disorder,and can lead to substantial disability in some patients.Although it presents some degree of clinical variability,it occurs in sporadic(SET)and familial(FET)forms with heterogeneity of expression between and within families[3].ET is characterized essentially by a postural and kinetic tremor most often affecting the arms,but it can also affect other parts of the body[4].Nonetheless,familial expression of ET has been linked to some loci[5–7]. | Ali Sazci Nihal Uren Halil Atilla Idrisoglu Emel Ergul | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 9 | Resveratrol-caused apop- tosis of human prostate carcinoma LNCaP ceils is mediated via modulation of Phosphatidylinositol 3 '-kinase/Akt pathway and Bcl- 2 family proteins显示文摘 | Moammir H A Nihal M Fu V X | 2006 | Mol Cancer Ther2006，5，5： | 1 |
| 10 | Turkish version of the Omaha System:its use in practice-based family nursing education nurse education today显示文摘 | Semra E Nihal ME | 2006 | Nurse Education Today2006，26，： | 1 |
| 11 | Heterogeneous photo-Fenton oxidation of reactive azo dye solutions using iron exchanged zeolite as a catalyst显示文摘 | Mesut Tekba? H. Cengiz Yatmaz Nihal Bekta? | 2008 | Microporous and Mesoporous Materials2008，，3： | 1 |
| 12 | SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis 显示文摘 | Nihal M Ahmad N Wood GS | 2014 | Cell Cycle2014，13，4： | 1 |
| 13 | Turkish Grade 10 Students' and Science Teachers' Conceptions of Nature of Science: A National Study 显示文摘 | Nihal Dgan Fouad Abd-El-Khalick | 2008 | Journal of Research In Science Teaching2008，45，10： | 1 |
| 14 | The manufacture of microencapsulated phase change materials suitable for the design of thermally enhanced fabrics显示文摘 | Nihal Sarier Emel Onder | 2007 | Thermochimica Acta2007，452，： | 1 |
| 15 | Anetoderma arising in cutaneous B-cell lymphoproliferative disease显示文摘 | Kasper RC Wood GS Nihal M | 2001 | Am J Dennatopathol2001，23，2： | 1 |
| 16 | Extreme preterm premature rupture of membranes:Risk factors and feto maternal outcomes显示文摘 | Nihal Al Riyami Intisar A1-Ruheili Fatma A1-Shezaw | 2013 | Oman Med J2013，28，2： | 1 |
| 17 | Intramedullary hip screw versus sliding hip screw for unstable intertrochanteric femoral fractures in the elderly 显示文摘 | Harrington P Nihal A Singhanin AK | 2002 | Injury2002，33，1： | 1 |
| 18 | Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication显示文摘 | Nai-Yun Hsu Olha Ilnytska Georgiy Belov Marianita Santiana Ying-Han Chen Peter M. Takvorian Cyrilla Pau Hilde van der Schaar Neerja Kaushik-Basu Tamas Balla Craig E. Cameron Ellie Ehrenfeld Frank J.M. van Kuppeveld Nihal Altan-Bonnet | 2010 | Cell2010，，5： | 1 |
| 19 | Opportunities for sustain able industrial development in Turkey:Eco-indus- trial Parks显示文摘 | Nihal S Albayrak A N | 2011 | Journal of Science2011，24，3： | 1 |
| 20 | Organic phase change materials and their textile applications:an overview显示文摘 | Sarier Nihal Onder Emel | 2012 | Thermochimica Acta2012，540，14： | 1 |
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