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| 1 | Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration显示文摘Diabetes mellitus is a serious threat to human health.Cyclocarya paliurus(Batal.)Iljinskaja(C.paliurus)is one of the traditional herbal medicine and food in China for treating type 2 diabetes,and the C.paliurus polysaccharides(CP)were found to be one of its major functional constituents.This research aimed at investigating the hypoglycemic mechanism for CP.It was found that CP markedly attenuated the symptoms of diabetes,and inhibited the protein expression of Bax,improved the expression of Bcl-2 in pancreas of diabetic rats,normalized hormones secretion and controlled the inflammation which contributed to the regeneration of pancreaticβ-cell and insulin resistance.CP treatment increased the beneficial bacteria genus Ruminococcaceae UCG-005 which was reported to be a key genus for protecting against diabetes,and the fecal short-chain fatty acids levels were elevated.Uric metabolites analysis showed that CP treatment helped to protect with the diabetes by seven significantly improved pathways closely with the nutrition metabolism(amino acids and purine)and energy metabolism(TCA cycle),which could help to build up the intestinal epithelial cell defense for the inflammation associated with the diabetes.Our study highlights the specific mechanism of prebiotics to attenuate diabetes through multi-path of gut microbiota and host metabolism. | Qiqiong Li Jielun Hu Qixing Nie Xiao Chang Qingying Fang Junhua Xie Haishan Li Shaoping Nie | 2021 | Science China(Life Sciences)2021，64，1： | 11 |
| 2 | Non-obstructive Coronary Artery Disease in Chinese Patients with Angina Diagnosed by Coronary Angiography:A Retrospective Study显示文摘Objective:This study aimed to estimate the proportion of non-obstructive coronary artery disease(CAD)patients in large percutaneous coronary intervention(PCI)centers in China.Methods:The study was conducted at 6 large PCI centers in China from January 1,2013 to December 31,2015.Demographic and clinical data were collected from medical records,prescription records,and laboratory reports of patients with symptoms of angina who underwent coronary angiography(CAG).Results:A total of 1713 patients were consecutively screened,1600 of whom were included in the study.CAG showed that 300 patients had non-obstructive CAD while 1300 had obstructive CAD.Among the 300 patients with non-obstructive CAD,203 displayed mild coronary stenosis(20%-49%)and 91 had normal coronary status(ie,<20%stenosis).Of the 1300 patients with obstructive CAD,61.6%(801/1300)had typical symptoms of angina,compared with 49.3%(148/300)for patients with nonobstructive CAD.In addition,there were more women than men in the non-obstructive CAD group,whereas the reverse was observed among obstructive CAD patients.Conclusion:The prevalence of non-obstructive CAD in the Chinese population with coronary heart disease was estimated to be approximately 20%.Additionally,typical angina symptoms were correlated with obstructive CAD,whereas female gender was identified as a risk factor for non-obstructive CAD. | Chengfei Peng Shaoping Nie Yingxian Sun Hui Chen Zuyi Yuan Yanjun Gong Xiaozeng Wang Yaling Han | 2021 | Cardiology Discovery2021，1，4： | 4 |
| 3 | Effect of pH,temperature and heating time on the formation of furan in sugar–glycine model systems显示文摘Furan(C4H4O)has been classified as a possible animal and human carcinogen by many international agencies.The formation of furan in three sugar–glycine models using glucose,fructose,and sucrose was investigated using headspace gas chromatography mass spectrometry method(HSGC–MS)with various dual combinations of three important heat processing conditions,i.e.pH,temperature,and heating time.Results indicated that furan levels from sugar–glycine model systems during the thermal processing can be attributed to selective sugar types,pH,temperature,and heating time.In glucose–glycine and fructose–glycine system,the lowest furan level was detected in acid condition but in sucrose–glycine system furan formed significantly lower(P<0.05)in acidic conditions the lowest furan level was found in alkaline conditions.The furan levels were observed to increase with heating time in all three model systems.Furthermore,less furan was generated in non-reducing sugar system(sucrose)than in reducing sugar system(glucose and fructose).Therefore,they demonstrate the possibility of limiting the formation of furan in heat processed foods by both the careful selection of carbohydrates(i.e.non-reducing sugars and reducing sugars)ingredients and appropriate processing conditions.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Shaoping Nie Jungen Huang Jielun Hu Yanan Zhang Sunan Wang Chang Li Massimo Marcone Mingyong Xie | 2013 | Food Science and Human Wellness2013，2，2： | 4 |
| 4 | Nonfatal Child Pedestrian Injury in Two Urban Cities of Guangdong Province,China:Results from a Cross-sectional Survey显示文摘Objective To describe the epidemiological characteristics of nonfatal child pedestrian injuries and provide information to help understand an important public-health problem.Methods This was a school-based,cross-sectional questionnaire survey.The sample (42 750 children) was obtained from two urban cities of Guangdong Province,China,using multi-stage randomized sampling.Information was collected by the respondents self-reporting in the classroom.Results The incidence rate of nonfatal child pedestrian injuries in the cities was 2.0%.Boys had a higher incidence rate (2.6%) than girls (1.4%).Compared to other children,those aged 10 years are at the highest risk.The primary places of occurrence were sidewalks,residential roads,and crosswalks.High-risk behavior of the children immediately prior to injury included mid-block crossings,playing on roads,and crossing on red lights.The major vehicles that caused pedestrian injuries were bicycles,car or vans,and motorcycles.Bruises,fractures,and injuries to the internal organs were the top three types of injuries.Almost 40% of victims were hospitalized,and nearly 30% of the victims suffered long-term disabilities.Conclusion This study shows that nonfatal child pedestrian injuries are a very serious public-health problem in the urban cities of Guangdong.Based on the epidemiological characteristics,prevention strategies and further research should be carried out to reduce the occurrence of injuries. | MA WenJun NIE ShaoPing XU HaoFeng XU YanJun XIE HuiYan ZHANG YuRun | 2011 | Biomedical and Environmental Sciences2011，24，4： | 4 |
| 5 | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health显示文摘Polysaccharide was a class of macromolecular substance with various bioactive functions.Gut symbiotic microorganisms could utilize the polysaccharides from various sources,thus have important impact on human health.Bacteroides represented one of the dominant colonizers in the human gut.The utilization of polysaccharide by Bacteroides was important for supporting the function and stability of gut microbiota.After the degradation of polysaccharides by Bacteroides,gut microbes could ferment the monosaccharides and oligosaccharides degraded from polysaccharides into some metabolites,such as short-chain fatty acids(SCFAs),amino acids,etc.Among the metabolites,the SCFAs could have beneficial effects on gut health.This review summarized the niches of Bacteroides among gut microbiota,and also described the gene clusters and membrane proteins involved in the utilization processes of polysaccharide by gut Bacteroides.SCFAs could act as energy substrates for intestinal epithelial cells,inhibit histone deacetylases and activate G protein-coupled receptors.In addition,the future perspectives in investigating new degradation pathways for polysaccharide,and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided. | Jiaobo Cheng Jielun Hu Fang Geng Shaoping Nie | 2022 | Food Science and Human Wellness2022，11，5： | 3 |
| 6 | The analysis of trans fatty acid profiles in deep frying palm oil and chicken fillets with an improved gas chromatography method显示文摘 | Yi Chen Ying Yang Shaoping Nie Xi Yang Yuting Wang Meiyan Yang Chang Li Mingyong Xie | 2014 | Food Control2014，，： | 2 |
| 7 | (-) - Epigallocatechin- 3- gallate Induces Apoptosis of Human Hepatoma Cells by Mitochondrial Pathways Related to Reactive Oxygen Species 显示文摘 | Li Wenjuan Nie Shaoping Yu Qiang | 2009 | Food Chem2009，57，15： | 1 |
| 8 | A review of isolation process, structural characteristics, and bioactivities of water-soluble polysaccharides from Dendrobium plants显示文摘 | Xiaohui Xing Steve W. Cui Shaoping Nie Glyn O. Phillips H. Douglas Goff Qi Wang | 2013 | Bioactive Carbohydrates and Dietary Fibre2013，，2： | 1 |
| 9 | Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum显示文摘 | CHEN Yi XIE Mingyong NIE Shaoping | 2008 | Food Chemistry2008，107，1： | 1 |
| 10 | Functional Analysis of Discoidin Domain Receptor 2 in Synovial Fibroblasts in Rheumatoid Arthritis显示文摘 | Jicun Wang Houshan Lü Xinping Liu Yanchun Deng Tiezheng Sun Fuyang Li Shaoping Ji Xiaoyan Nie Libo Yao | 2002 | Journal of Autoimmunity2002，，3： | 1 |
| 11 | Purification, composition analysis and antioxidant activity of a polysaeeharide from the fruiting bodies of Ganoderma atrum显示文摘 | CHEN Yi XIE Mingyong NIE Shaoping | 2008 | Food Chemistry2008，107，： | 1 |
| 12 | Purification,composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum显示文摘 | CHEN Yi XIE Mingyong NIE Shaoping | 2008 | Food Chemistry2008，107，1： | 1 |
| 13 | Analysis and formation of trans fatty acids in com oil during the heating process显示文摘 | YANG Meiyan YANG Ying NIE Shaoping | 2012 | Journal of the American Oil Chemists Society2012，89，5： | 1 |
| 14 | Purification, composition analysis and antioxidant activity of a po|ysaccharide from the fruiting bodies of Ganoderma atrum显示文摘 | Chen Yi Xie Mingyong Nie Shaoping | 2008 | Food Chemistry2008，107，： | 1 |
| 15 | Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities显示文摘 | Yi Chen Hui Zhang Yuanxing Wang Shaoping Nie Chang Li Mingyong Xie | 2014 | Food Chemistry2014，，： | 1 |
| 16 | Purification,composition analysis andantioxidant activity of a polysaccharide from the fruiting bodies of ganoderma atrum显示文摘 | CHEN Yi XIE Mingyong NIE Shaoping | 2008 | Food Chemistry2008，107，1： | 1 |
| 17 | Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum显示文摘 | Chen Yi Xie Mingyong Nie Shaoping | 2008 | Food Chemistry2008，，107： | 1 |
| 18 | Purification,composition analysis and antioxidant activityof a polysaccharidefrom the fruiting bodies of Ganoderma atrum 显示文摘 | Chen Yi Xie Mingyong Nie Shaoping | 2008 | Food Chemistry2008，107，： | 1 |
| 19 | Simultaneous analysis of 18 mineral elements in Cyclocarya paliurus polysaccharide by ICP-AES显示文摘 | XIE Jianhua SHEN Mingyue NIE Shaoping | 2013 | Carbohydrate Polymers2013，94，： | 1 |
| 20 | Determination of specia- tion of elements related to blood sugar in bioactive extracts from Cyclocary apaliurus leaves by FIA-ICP-MS 显示文摘 | XIE Mingyong LI Lei NIE Shaoping | 2006 | European Food Research and Technology2006，223，2： | 1 |
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