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| 1 | Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy显示文摘AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in colonoscopy.METHODS:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were compared.RESULTS:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white light.The mucosal surface was best assessed using filter 4.However,the views obtained were not rated significantly better than those observed with white light.The 'gold standard',indigo carmine(IC) dye,was found to be superior to both white light and filter 4.Filter 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained mucosa.When assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light imaging.In the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white light.CONCLUSION:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE. | Adolfo Parra-Blanco Alejandro Jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero | 2009 | World Journal of Gastroenterology2009，15，42： | 12 |
| 2 | Endoscopic submucosal dissection training with pig models in a Western country显示文摘AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning curve.METHODS:ESD was attempted in ex vivo and in vivo pig models.Thirty ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was achieved.In the in vivo model,several ESD procedures were performed in up to 3 sessions.The following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and complications.RESULTS:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 mm.The mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not differ.CONCLUSION:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans. | Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 3 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 4 | Ion-exchange equilibria of Ni2+ , Co2+ , Mn2+ and Mg2+ with iminodiacetic acid chelating res- in Amberlite IRC 748 显示文摘 | Zainol Z Nicol M J | 2009 | Hydrometallurgy2009，99，4： | 1 |
| 5 | More than child's play :Var- iable-and pattern-centered approaches for examining effects of sports participation on youth development 显示文摘 | NICOLE Z KRISTEN F YIBING L el al | 2009 | Dev Psych2009，2，45： | 1 |
| 6 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 7 | Role of p53 in G2/M cell cycle arrest and apoptosis in response to γ-irradiation in ovarian carcinoma cell lines显示文摘 | NICOLE C MARGIT S CHRISTA Z | 2003 | International J Oncology2003，22，： | 1 |
| 8 | Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women显示文摘 | George W Peter T Beverley S Gordon G Joan P Nicole Z Vivian R David H Diane O Ann C | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 9 | Meta-Analysis of Raloxifene for the Prevention and Treatment of Postmenopausal Osteoporosis显示文摘 | Ann C Peter T Nicole Z Vivian R Bruce W Jonathan A George W Beverley S Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 10 | Role of matrix metalloproteinase-9 (MMP-9) dimers in cell migration : design of inhibitory peptides 显示文摘 | Antoine D Stanley Z Nicole S | 2010 | J Biol Chem2010，285，35： | 1 |
| 11 | Meta-Analysis of Calcitonin for theTreatment of Postmenopausal Osteoporesis显示文摘 | Ann C Peter T Nicole Z et a1 | 2002 | Endocrine Rev2002，23，4： | 1 |
| 12 | Meta-Analysis of the Efficacy of Vitamin D Treatment in Preventing Osteoporosis in Postmenopausal Women显示文摘 | Emmanuel P George W Beverley S William G Bruce W Nicole Z Ann C Jonathan A Peter T Robert J Carol G Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 13 | Ditopic Calixcrowns With Inequivalent Crown Loops:Synthesis and Structural Characterization of an Unsymmetrical Calix arenebiscrown-6显示文摘 | Asfari Z Nicolle X Vicens J | 1999 | J Incl Phenom Macrocyclic Chem1999，33，： | 1 |
| 14 | Identification of a peptide inhibitor of the cardiac sarcolemmal Na +/Ca + + exchanger 显示文摘 | Nicoll DA Collins A | 1991 | J Biol Chemi1991，266，： | 1 |
| 15 | Relationships between population densities of the cereal cyst nematode, Heterodera latipons and yield losses of winter wheat in micro- plots显示文摘 | Hajihasani A Tanha Maafi Z Nicol J M | 2010 | Australasian Plant Pathology2010，39，： | 1 |
| 16 | Meta-Analysis of Risedronate for the Treatment of Postmenopausal Osteoporosis显示文摘 | Ann C Peter T Jonathan A Bruce W Nicole Z Alexandra P Vivian R Beverley S George W Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 17 | On-road demonstration of NOx emission control for diesel trucks with SNO,urea SCR system 显示文摘 | Nicole F Wieland M Juergen Z | 1999 | SAE Paper1999，，： | 1 |
| 18 | Nitrosospira ssp can produce nitrous oxide via a nitrifier denitrification pathway 显示文摘 | Shaw L J Nicol G W Smith Z Fear J | 2006 | Evnironmental Microbiology2006，8，2： | 1 |
| 19 | Ion-exchange equilibria of Ni2 + , Co2+ , Mn2 + and Mg2 + with iminodiacetic acid che- lating resin Amberlite IRC 748 显示文摘 | ZAINOL Z NICOL M J | 2009 | Hydrometallurgy2009，99，34： | 1 |
| 20 | Maleic Anhydride CopolymersA Versatile Platform for Molecular Biosurface Engineering 显示文摘 | Tilo P Stefan Z Nicole H | 2003 | Biomacromolecules2003，4，： | 1 |
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