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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 4 | 炉料金属化率对高炉工艺和操作参数的影响显示文摘针对不同金属化率的炉料,采用离散物料平衡和热平衡系统,描述了铁矿在高炉内还原和熔化过程中的传热和传质。该计算模型将高炉在垂直方向分为12层,沿半径方向分成10圈。结果表明,随着炉料金属化率的提高,直接还原所需的热量和热流比减少,导致高炉下部传热强度降低,这可使高炉下部高度增加而上部高度减小。煤气等温线上移,炉顶热损失增加。同时,软熔带上移,区间扩大,布料对高炉操作参数的影响减弱。由于直接还原度的降低,喷吹天然气对焦比的影响减小。当炉料金属化率大于20%时,金属化炉料的使用并不能降低焦比。 | I G Tovarovskiy Y M Gordon A E Merkulov 张友平(译) 徐万仁(校) | 2013 | 世界钢铁2013，，5： | 4 |
| 5 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 6 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 7 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 8 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 9 | The oscillation frequency of a quartz crystals immersed in organic liquids 显示文摘 | Kanazawa K K Gordon J G | 1985 | Anal Chim Acta1985，175，9： | 2 |
| 10 | Mannose-binding lectin and maladies of the bowel and liver显示文摘Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate mo-tifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infec-tious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immuno-logical damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease. | Daniel L Worthley Peter G Bardy David L Gordon Charles G Mullighan | 2006 | World Journal of Gastroenterology2006，12，40： | 2 |
| 11 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 12 | Disproportionation of chlorous acid, Part 1, Stoichiometry 显示文摘 | Kieffer R G Gordon G | 1968 | Inorganic Chemistry1968，7，3： | 1 |
| 13 | Dimensinal stability and detail reproduction of irreversible hydrocolloid and elastomeric impressions disinfected by immersion显示文摘 | Johoson G H Chellis K D Gordon G E | 1998 | J Prosthet Dent1998，79，4： | 1 |
| 14 | The G-protein-gated atrial K+ channel Ikach is a heteromultimer of two inwardly rectifying K+-channel proteins显示文摘 | Krapivisky G Gordon EA Wickman | 1995 | Nature1995，374，： | 1 |
| 15 | Perceived earnings functions and Ex Ante rates of return to post compuloryeducation in England显示文摘 | WILLIAMS G GORDON A | 1981 | Higher Education1981，10，： | 1 |
| 16 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 17 | Understanding relationships among multiple ecosystem services显示文摘 | Bennett E M Peterson G D Gordon L J | 2009 | Ecol Let2009，，12： | 1 |
| 18 | Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma 显示文摘 | Gordon G J Dung L Yeap BY | 2009 | J Natl Cancer Inst2009，101，： | 1 |
| 19 | Role of Spl,C/EBPα, HNF3 and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene 显示文摘 | Vicent B Kevin T Gordon G | 2004 | Drug Metab Dispos2004，32，： | 1 |
| 20 | Cloning and characterization of the murine manganous superoxide dismutase -encoding gene显示文摘 | Jones PL Kucera G Gordon H | 1995 | Gene1995，153，2： | 1 |
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