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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | EBV阴性侵袭性NK细胞白血病/淋巴瘤的临床、病理及分子遗传学特征显示文摘侵袭性NK细胞淋巴瘤(ANKL)是一种系统性NK细胞肿瘤,与EB病毒(EBV)有关。EBV阴性的ANKL临床罕见,且提示具有惰性的生物学行为。作者报道7例EBV阴性ANKL的临床病理、免疫表型及分子遗传学特征。 | Nicolae A Ganapathi K A Pham T H 魏建国 许春伟 | 2017 | 临床与实验病理学杂志2017，33，5： | 10 |
| 3 | “En bloc ” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer显示文摘There are diverse protocols to manage patients with recurrent disease after primary cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC) for peritoneal carcinomatosis. We describe a case of metachronous liver metastasis after CRS and HIPEC for colorectal cancer, successfully treated with a selective metastectomy and partial graft of the inferior vena cava. A 35-year-old female presented with a large tumour in the cecum and consequent colonic stenosis. After an emergency right colectomy, the patient received adjuvant chemotherapy. One year later she was diagnosed with peritoneal carcinomatosis, and it was decided to carry out a CRS/HIPEC. After 2 years of total remission, an isolated metachronous liver metastasis was detected by magnetic resonance imaging surveillance. The patient underwent a third procedure including a caudate lobe and partial inferior vena cava resection with a prosthetic graft interposition, achieving an R0 situation. The postoperative course was uneventful and the patient was discharged on postoperative day 17 after the liver resection. At 18-mo follow-up after the liver resection the patient remained free of recurrence. In selected patients, the option of re-operation due to recurrent disease should be discussed. Even liver resection of a metachronous metastasis and an extended vascular resection are acceptable after CRS/HIPEC and can be considered as a potential treatment option to remove all macroscopic lesions. | Patricia Sánchez-Velázquez Nicolas Moosmann Ingolf T?pel Pompiliu Piso | 2016 | World Journal of Gastroenterology2016，22，46： | 3 |
| 4 | Effect of Annealing Temperature on Film Morphology of Organic–Inorganic Hybrid Pervoskite Solid‐State Solar Cells显示文摘 | Amalie Dualeh Nicolas Tétreault Thomas Moehl Peng Gao Mohammad Khaja Nazeeruddin Michael Gr?tzel | 2014 | Adv. Funct. Mater2014，，21： | 2 |
| 5 | Characterization of VIM-2,a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid-and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France显示文摘 | POIREL L NAAS T NICOLAS D | 2000 | Antimicrob Agents Chemother2000，44，4： | 1 |
| 6 | Tensile Testing of Materials at High Rates of Strain显示文摘 | Nicolas T | 1981 | Experimental Mechanics1981，，21： | 1 |
| 7 | Remote sensing of spring phenology in boreal regions:A free of snow-effect method using NOAA-AVHRR and SPOT-VGT data显示文摘 | NICOLAS D THUY L T LAURENT K | | 0，，01： | 1 |
| 8 | Characterization of VIM-2, a carbapenem-Hydrolyzing Metallo-β-lactamase and its plasmid and integrin-home gene from a pseudomonas aeruginosa clinical isolate in France显示文摘 | Poirel L Naas T Nicolas D | 2000 | Antimicrob Agents Chemother2000，44，4： | 1 |
| 9 | Ring enhancement in ul trasmall superparamagnetic iron oxide MR imaging: A potential new sign for characterization of liver lesions 显示文摘 | Mergo P Helmeberg T Nicolas AI | 1996 | Am J Roentgenol1996，166，2： | 1 |
| 10 | Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France显示文摘 | Poirel L Naas T Nicolas D | 2000 | Antimicrob Agents Chemother2000，44，4： | 1 |
| 11 | Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plas mid-and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France显示文摘 | Poirel L Naas T Nicolas D | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 12 | Detection and mapping of oil slicks in the sea by combined use of hyperspectral imagery and laster-induced fluorescence 显示文摘 | MARC L SERGEY B NICOLAS T | 2006 | EARSeL eProceedings2006，，： | 1 |
| 13 | Layer-by-layer films as a biomimetic reservoir for rhBMP--2 delivery: Controlled differentiation of myoblasts to osteoblasts显示文摘 | Crouzier T Ren K F Nicolas C | 2009 | Small2009，5，5： | 1 |
| 14 | Diagnostic accuracy of the Anti-citrulline Antibody assay for rheumatoid arthritis 显示文摘 | Nicola B Giovanni M Elio T | 2001 | Clin chem2001，47，： | 1 |
| 15 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T De Nicola F Guerrieri F Raffa G Fanciulli M | | Proceedings of the National Academy of Sciences(USA)0，，： | 1 |
| 16 | Characterization of VIM-2, a carbapenem - hydrolyzing metallo -β- lactamase and its plasmid- and integron - borne gene from a Pseudomonas aeruginosa clinical isolate in France 显示文摘 | Poirel L Naas T Nicolas D | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 17 | Magnetos- trictive actuators compared to piezoelectric actuators显示文摘 | FRANK C NICOLAS L MAILLARD T | 2003 | European Workshop on Smart Structures in Engineering and Technology Proceedings of SPIE2003，4763，： | 1 |
| 18 | Characterization of VIM-2,a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid-and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France显示文摘 | Poirel L Naas T Nicolas D | | 0，，04： | 1 |
| 19 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
| 20 | Remote sensing of spring phenology in boreal regions : A free of snow - effect method using NOAA - AVHRR and SPOT - VGT data 显示文摘 | Nicolas D Thuy L T Laurent K | 2006 | Remote Sensing of Environment2006，101，1： | 1 |
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