|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 3 | 基于ENVISAT ASAR数据的水稻估产方案显示文摘水稻多生长在温暖潮湿的多云多雨地区,使雷达遥感成为水稻遥感监测的重要手段之一.因此,提出应用多时相、多极化ENVISAT ASAR数据进行区域水稻估产的方案.首先利用ASAR数据进行水稻制图,提取水稻种植分布图和多时相水稻后向散射系数.随后,基于像元尺度,采用同化估产方法,以LAI为结合点,将水稻作物模型ORYZA2000与半经验水稻后向散射模型结合,建立嵌套模型模拟多时相水稻后向散射系数.对ORYZA2000模型进行参数敏感性分析,选择水稻出苗期和播种密度为参数优化对象.利用全局优化算法SCE-UA对优化参数进行重新初始化,以使模拟的水稻后向散射系数与实测值误差最小,并利用优化后的ORYZA2000模型计算每个像元的水稻产量,生成区域的水稻产量分布图.最后,使用2006年在中国兴化地区进行的水稻同步试验数据对该方案进行了验证.结果表明,由于采用潜在生长条件模拟,模拟的水稻产量明显高于实测产量,其平均值比实际情形高约13,根均方误差达到1133kg/hm2,但获取的水稻产量分布图能够描绘研究区水稻实际产量的分布趋势.由此可见,该方案为多云多雨地区的水稻遥感监测提供了重要参考. | 申双和 杨沈斌 李秉柏 谭炳香 李增元 Le Toan Thuy | 2009 | 中国科学(D辑)2009，，6： | 11 |
| 4 | The first dinosaur tracksite from Xinjiang, NW China (Middle Jurassic Sanjianfang Formation, Turpan Basin)──a preliminary report显示文摘A new dinosaur tracksite was discovered in a steeply inclined sandstone layer of the Middle Jurassic Sanjianfang Formation in the Shanshan area of the Turpan Basin. The site is the first record of dinosaur footprints from Xinjiang Province in northwestern China. More than 150 tridactyl theropod dinosaur footprints are preserved as positive hyporeliefs on the lower bedding plane of a fine-grained sandstone body. Most of the footprints are isolated and appear to be randomly distributed. Some show well defined phalangeal pads, heels and rarely indistinct impressions of the distal part of the metatarsus. Two distinct morphotypes are present: a larger type with relatively broad pads shows similarities to Changpeipus and Megalosauripus, and a slightly smaller, slender and gracile type which is similar to Grallator, Eubrontes and Anchisauripus. In both morphotypes, digit III is the longest with a length between 11.4 and 33.6 cm. A single imprint shows prominent scratches, probably formed during slipping of the track maker. | Oliver WINCS Rico SCHELLHORN Heinrich MALLISON Ben THUY Wenhao WU Ge SUN | 2007 | Global Geology2007，10，2： | 8 |
| 5 | 基于强度理论及虚拟仿真相结合的行星减速机构可靠性分析显示文摘基于破煤理论建立了采煤机的力学模型,采用ADAMS建立采煤机刚柔耦合模型,并解决了边界条件添加、接触法向力提取等技术问题,分析了行星轴、架的可靠性;基于行星减速机构强度校核基本原理,开发了行星齿轮强度校核软件,以虚拟仿真中的动态接触法向力为输入,对某公司两种行星减速机构设计方案中各齿轮的接触应力和弯曲应力进行研究。该方法解决了传统分析中齿轮受力无法确定以及采用有限元软件无法求解齿根弯曲应力、求解接触应力时间过长的不足。结果表明:二级行星减速机构采用4行星轮结构要优于采用3行星轮方案,传动更稳定、可靠。 | 刘旭南 赵丽娟 高猛 LE THUY DUONG | 2016 | 中国安全生产科学技术2016，12，2： | 8 |
| 6 | A scheme for regional rice yield estimation using ENVISAT ASAR data显示文摘Information on rice growing areas and rice production is critical for most rice growing countries to make state and economic policies. However, the areas where rice crop is cultivated are often cloudy and rainy, which entails the use of radar remote sensing data for rice monitoring. In this paper, a practical scheme to integrate multi-temporal and multi-polarization ENVISAT ASAR data into rice crop model for regional rice yield estimation has been presented. To achieve this, rice distribution information should be obtained first by rice mapping method to retrieve rice fields from ASAR images, and then an assimilation method is applied to use the observed multi-temporal rice backscattering coefficients which are grouped for each rice pixel to re-initialize ORYZA2000 to predict rice yield. The assimilation method re-initializes the model with optimal input parameters, allowing a better temporal agreement between the rice backscattering coefficients retrieved from ASAR data and the rice backscattering coefficients simulated by a coupled model, i.e., the combination of ORYZA2000 and a semi-empirical rice backscatter model through LAI. The SCE-UA optimization algorithm is employed to determine the optimal set of input parameters. After the re-initialization, rice yield for each rice pixel is calculated, and the yield map over the area of interest is produced. The scheme was validated over Xinghua study area located in the middle of Jiangsu Province of China by using the data set of an experimental campaign carried out during the 2006 rice season. The result shows that the obtained rice yield map generally overestimates the actual rice production by 13% on average and with a root mean square error of approximately 1133 kg/ha on validation sites, but the tendency of rice growth status and spatial variation of the rice yield are well predicted and highly consistent with the actual production variation. | LE TOAN Thuy | 2009 | Science China Earth Sciences2009，52，8： | 7 |
| 7 | Activated carbon derived from rice husk by NaOH activation and its application in supercapacitor显示文摘Four activated carbon(AC) samples prepared from rice husk under different activation temperatures have been characterized by N2adsorption–desorption isotherms, thermogravimetric analysis(TGA–DTA), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). The specific surface area of AC sample reached 2681 m2 g 1under activation temperature of 800 1C. The AC samples were then tested as electrode material; the specific capacitance of the as-prepared activated carbon electrode was found to be 172.3 F g 1using cyclic voltammetry at a scan rate of 5 mV s 1and 198.4 F g 1at current density 1000 mA g 1in the charge/discharge mode.& 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved. | Khu Le Van Thu Thuy Luong Thi | 2014 | Progress in Natural Science:Materials International2014，24，3： | 7 |
| 8 | 越南西北部莱州地区新生代煌斑岩地球化学特征及其成因显示文摘越南西北部莱州地区出露的新生代煌斑岩岩脉对理解特提斯造山带东段的深部岩石圈特征和演化具有重要的地质意义。本文报道莱州地区煌斑岩的元素地球化学和Sr-Nd-Pb同位素组成特征,探讨其岩石成因。该地区煌斑岩属于钙碱性,钾质-超钾质煌斑岩特征。地球化学特征对比表明,莱州地区煌斑岩与哀牢山断裂带碱性岩具有相似的地球化学特征,但与海南和越南南部火山岩存在明显差异。分析结果表明,煌斑岩具有高的87Sr/86Sr比值、低143Nd/144Nd比值和高放射性成因Pb同位素组成特征。岩石的微量元素组成特征指示,形成煌斑岩的地幔源区可能经历过流体交代作用或沉积物组分的加入。低208Pb*/206Pb*比值暗示地幔源区富集事件是近期发生的,可能与晚古生代-早中生代印支地块向扬子地块俯冲事件有关。 | 杨一增 龙群 胡焕婷 HIEU Pham Trung NGUYEN Thi Bich Thuy 陈福坤 | 2013 | 岩石学报2013，29，3： | 6 |
| 9 | 荨麻属药用植物的研究进展显示文摘目的:荨麻属植物的化学成分多样,药理活性明显,且应用广泛。本文综述近二十年的研究现状,为其进一步开发利用提供科学依据。方法:结合国内外相关文献,对药用荨麻属植物的化学成分、药理作用、质量控制、安全性评价、开发应用等方面进行综述。结果:从荨麻属药用植物中分离鉴定了黄酮、木脂素、香豆素、甾体、有机酸类成分。药用荨麻属植物具有良好的抑制良性前列腺增生、抗风湿、降血糖、镇痛、抗炎、抗菌、抗氧化等活性。临床主要应用于良性前列腺增生、风湿、类风湿关节炎等,疗效显著。今后应加强药用荨麻的质量评价、安全性控制等方面的研究。结论:荨麻属植物具有较高的研究价值。 | LUU THI THANH THUY 王梦月 | 2015 | 中国民族民间医药2015，24，12： | 5 |
| 10 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 11 | 荨麻根脂溶性化学成分研究显示文摘目的对荨麻根的脂溶性成分进行研究。方法采用硅胶、Sephadex LH-20、ODS柱色谱以及半制备HPLC等方法分离、纯化,根据化合物的理化性质和光谱数据鉴定结构。结果从荨麻根乙酸乙酯部位分离鉴定了21个成分,分别为:(-)-荨麻醇(1)、(-)-开环异落叶松脂素(2)、23-羟基白桦脂酸(3)、2α,3β,24-三羟基-齐墩果-12-烯-28-羧酸(4)、臭矢菜素A(5)、二氢-4-羟基-5-羟甲基-2(3H)-呋喃酮(6)、绿原酸甲酯(7)、山柰酚(8)、松脂素单甲基醚-4'-O-β-D-葡萄糖苷(9)、罗汉松脂素-4'-O-β-D-葡萄糖苷(10)、环橄榄脂素-6-O-β-D-吡喃葡萄糖苷(11)、豆甾醇-3-O-β-D-葡萄糖苷(12)、烟酰胺(13)、反式咖啡酸-4-O-β-D-葡萄糖苷(14)、七叶苷(15)、5-羟基-7-甲氧基香豆素-8-O-β-D-葡萄糖苷(16)、6-甲氧基-木犀草素-7-O-β-D-葡萄糖苷(17)、木犀草素-7-O-β-D-葡萄糖苷(18)、槲皮素-3-O-(4″-甲氧基)-α-L-吡喃鼠李糖苷(19)、2'-脱氧尿苷(20)和芹菜素-6,8-二-C-β-D-葡萄糖苷(21)。结论除化合物8、12外,其余19个成分均为首次从荨麻中分得;化合物5、6、9、10、11、14、16、17、19均为首次从荨麻科植物中发现。 | 冯晓茹 李晓波 LUU THI THANH THUY 王梦月 | 2017 | 中国药学杂志2017，52，14： | 5 |
| 12 | 浅述老年湿疹的辨证论治显示文摘老年湿疹近年来有增高趋势,其病因病机及辨证用药有其自身特点,认为在病因病机上多存在阴阳失调、水液失运、气机失畅。辨证用药上应多注意养阴润肤、健脾助运、调畅气机。 | Nguyen Phuong Thuy 张诚昊 杨恩品 | 2016 | 天津中医药2016，33，2： | 5 |
| 13 | Xanthine oxidase inhibitors from Archidendron clypearia(Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants显示文摘Objective: To screen Vietnamese medicinal plants for xanthine oxidase(XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. Methods: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. Results: Three hundreds and eleven methanol extracts(CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 μg/m L with inhibition rates of over 50%. The extracts of Archidendron clypearia, Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC_(50) values below 30 μg/m L. Chemical study performed on the extract of Archidendron clypearia resulted in the isolation of six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and(-)-7-O-galloyltricetiflavan. The compound(-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC_(50) value of 25.5 μmol/L. Conclusions: From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC_(50) values of the methanol extracts below 30 μg/m L. Compound(-)-7-O-galloyltricetiflavan was identified as an XO inhibitor from Archidendron clypearia with IC_(50) value of 25.5 μmol/L. | Nguyen Thuy Duong Pham Duc Vinh Phuong Thien Thuong Nguyen Thi Hoai Le Nguyen Thanh Tran The Bach Nguyen Hai Nam Nguyen Hoang Anh | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，6： | 5 |
| 14 | RECENT PROGRESS IN STORM SURGE FORECASTING显示文摘This report briefly summarizes recent progress in storm surge forecasts, one of topics discussed during the fourth International Workshop on Tropical Cyclone Landfall Process(IWTCLP 4) held during 5-8 December, 2017. In the workshop, improvement of storm surge forecasting system was mainly discussed with relevance to the problem of estimating the impacts of tropical cyclone landfall.To deal with storm surges, accurate TC condition(predictions and forecasts) as input, reasonable storm surge predictions(with forecasting systems), and effective advisories/warnings(i.e. useful information products) are necessary. Therefore, we need to improve storm surge related matters systematically: input, prediction system, and ef fective information.This report tries to highlight recent progress in the field of storm surges in relation to three key points: improvement in storm surge forecasting models/system, TC conditions as input for storm surge predictions, and informative products for end users. | NADAO KOHNO SHISHIR K.DUBE MIKHAIL ENTEL S.H.M.FAKHRUDDIN DIANA GREENSLADE MARIE-DOMINIQUE LEROUX JAMIE RHOME NGUYEN BA THUY | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 15 | 全身麻醉剂激活杏仁核内一个强效的中枢镇痛环路显示文摘全身麻醉产生的镇痛作用独立于其引起意识消失的作用,但背后机制却不清楚。本研究假设全身麻醉药通过激活高级中枢产生镇痛。研究者发现小鼠中央杏仁核(CeA)存在一类特殊的由全身麻醉药激活的GABA能神经元集群(称作CeAGA神经元)。在体钙成像实验显示不同的全身麻醉药可激活共同的CeAGA神经元集群。CeAGA神经元有本底放电活动,但主要是反应小鼠身体的内部状态。光遗传兴奋CeAGA神经元显著减少疼痛引发的反射性行为和自愈性(如舔舐、擦拭)行为以及抑制慢性神经病理性疼痛引发的机械痛敏。相反,抑制CeAGA神经元活动会加剧疼痛,带来强烈的厌恶感并抑制低剂量氯胺酮的镇痛效应。此外,CeAGA神经元广泛投射到痛觉相关脑区。本研究表明CeAGA是缓解慢性疼痛的潜在的强效治疗靶标。 | Thuy Hua Bin Chen Dongye Lu 李紫阳(译) 张玲(校) | 2020 | 中国疼痛医学杂志2020，26，11： | 4 |
| 16 | Resistance to clopidogrel: A review of the evidence显示文摘 | Thuy Anh Nguyen Jean G. Diodati Chantal Pharand | 2005 | Journal of the American College of Cardiology2005，，8： | 3 |
| 17 | Genome-wide association study identifies QTL for eight fruit traits in cultivated tomato (Solanum lycopersicum L.)显示文摘Genome-wide association study(GWAS)is effective in identifying favorable alleles for traits of interest with high mapping resolution in crop species.In this study,we conducted GWAS to explore quantitative trait loci(QTL)for eight fruit traits using 162 tomato accessions with diverse genetic backgrounds.The eight traits included fruit weight,fruit width,fruit height,fruit shape index,pericarp thickness,locule number,fruit firmness,and brix.Phenotypic variations of these traits in the tomato collection were evaluated with three replicates in field trials over three years.We filtered 34,550 confident SNPs from the 51K Axiom®tomato array based on<10%of missing data and>5%of minor allele frequency for association analysis.The 162 tomato accessions were divided into seven clusters and their membership coefficients were used to account for population structure along with a kinship matrix.To identify marker-trait associations(MTAs),four phenotypic data sets representing each of three years and combined were independently analyzed in the multilocus mixed model(MLMM).A total of 30 significant MTAs was detected over data sets for eight fruit traits at P<0.0005.The number of MTA per trait ranged from one(brix)to seven(fruit weight and fruit width).Two SNP markers on chromosomes 1 and 2 were significantly associated with multiple traits,suggesting pleiotropic effects of QTL.Furthermore,16 of 30 MTAs suggest potential novel QTL for eight fruit traits.These results facilitate genetic dissection of tomato fruit traits and provide a useful resource to develop molecular tools for improving fruit traits via marker-assisted selection and genomic selection in tomato breeding programs. | Minkyung Kim Thuy Tien Phan Nguyen Joon-Hyung Ahn Gi-Jun Kim Sung-Chur Sim | 2021 | Horticulture Research2021，8，1： | 3 |
| 18 | 东亚气候变化与可持续发展——影响与政策挑战(英文)显示文摘气候变化已成为全球,特别是东亚国家可持续发展的挑战性问题。东亚地区由于海岸线长,人口密度大,经济对农业和资源依赖性强,极容易受气候变化的影响,而且影响深,持续时间长,制约了经济和社会的可持续发展。由于快速的城市化、工业化和经济发展,气候变化对资源和环境也构成威胁,使国家在食品安全、能源安全、环境和资源、减少碳排放和社会安全等方面的政策面临挑战。 | LE Thi Thuy Van | 2012 | 资源与产业2012，14，6： | 3 |
| 19 | GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms显示文摘Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.The present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,Slovakia.In this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were considered.Initially,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,respectively.The geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover factors.The ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model building.Consequently,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier models.Finally,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and models.The results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%). | Sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache Nguyen Thi Thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque Ahmad Mohammad Ali Ghorbani | 2021 | Geoscience Frontiers2021，12，2： | 3 |
| 20 | Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata显示文摘Objective:To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata(C.odorata).Methods:The compounds isolated from the aerial parts of C.odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.Results:Six fatty acids (S)-coriolic acid(1),(S)-coriolic acid methyl ester(2),(5)-15,16-didehydrocoriolic acid(3),(S)- 15,16-didehydrocoriolic acid methyl ester(4),linoleamide(5) and linolenamide(6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition.Compound 2 was the most active with the IC50 values of 5.22 and 5.73μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.Conclusions:The fatty acid components in C.odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine.This study could also contribute to the better use of C.odorata for human health care. | Tran Thi Hong Hanh Dan Thi Thuy Hang Chau Van Minh Nguyen Tien Dat | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员