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| 1 | TGF-β family co-receptor function and signaling显示文摘转变生长因素 --(TGF-) 家庭成员,它包括 TGF-s, activins 和骨头形态基因的蛋白质,是多种的 cytokines 得到细胞类型特定的效果在一高度在许多不同纸巾的上下文依赖者举止。经由 single-transmembrane 类型的这些分泌蛋白质 ligands 信号我和类型 II serine/threonine kinase 受体和细胞内部的 SMAD 抄写因素。在发信号的解除管制在疾病的一个宽广数组被含有,并且含有对复杂罚款在细胞的发信号的回答调节的需要。TGF- 家庭受体发信号紧张,持续时间,特性和差异被调整或调停的一重要出现机制通过房间表面合作受体。这里,我们提供为 TGF- 家庭成员被识别了的合作受体的概述。当一些看起来对 TGF- 家庭成员特定时,其它与另外的小径被分享并且为信号集成提供可能的方法。这评论集中于 TGF- 家庭合作受体的新奇功能,它继续发现。 | Joachim Nickel Peter ten Dijke Thomas D. Mueller | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 26 |
| 2 | 高场强MRI与超声内镜对可切除性食管癌术前T分期应用价值的比较显示文摘目的 比较高场强MRI与超声内镜(EUS)对可切除性食管癌患者术前T分期的应用价值。方法 前瞻性收集2015年3月至2016年9月经临床及病理活检判定为可切除性食管癌的患者,所有入组患者于病理活检1周后进行MRI,扫描序列包括膈肌导航的应用刀锋采集技术的快速自旋回波的T2WI加权成像(BLADE-TSE-T2WI)、DWI及自由呼吸放射状K空间填充方式的容积内插体部检查(radial-VIBE),同时行超声内镜(EUS)检查。MRI检查均在EUS之前进行,手术均在MRI与EUS检查后1周内进行。由2名具有5年以上MRI诊断经验的医师分别采用5分制对MR图像进行评分,参照美国癌症联合委员会(AJCC)第7版食管癌TNM分期标准。2名MRI阅片者采用双盲法分别对MR图像进行独立分期,结果不一致时,由第3名高级职称MRI医师共同讨论,达成一致意见,由1名具有5年以上内镜工作经验的内镜医师进行EUS分期。采用Kappa一致性检验,评价2名MRI阅片者对图像质量评分和可切除性食管癌术前T分期的一致性,以术后病理T分期结果为金标准,分别计算MRI及EUS对食管癌术前T分期的准确率,并采用χ2检验进行对照分析。结果 入组患者共70例,MRI图像质量评分不低于3分者分别有66例(阅片者1)和68例(阅片者2),2名MRI阅片者对图像质量评分的一致性非常好(Kappa=0.824,P〈0.05)。术后病理证实T1期16例、T2期18例、T3期30例、T4a期6例。2名MRI阅片者对食管癌术前T分期的一致性非常好(Kappa=0.809,P〈0.05),MRI和EUS对可切除性食管癌术前T分期的准确率分别为92.9%(65/70)和67.1%(47/70),两种技术的准确率差异有统计学意义(χ2=14.5,P〈0.05)。结论MRI对食管癌术前T分期的准确率明显高于EUS,可以成为判断食管癌术前T分期的无创性检查方法。 | 郭佳 王昭琦 张风光 张宏凯 鲁亚南 秦建军 张忠宪 张廷 张首宁 董亚锋 李印 赵妍 刘慧 严序 Dominik Nickel 黎海亮 曲金荣 | 2018 | 中华放射学杂志2018，52，3： | 23 |
| 3 | Perioperative visual loss after spine surgery显示文摘Perioperative visual loss(POVL) is an uncommon, but devastating complication that remains primarily associated with spine and cardiac surgery. The incidence and mechanisms of visual loss after surgery remain difficult to determine. According to the American Society of Anesthesiologists Postoperative Visual Loss Registry, the most common causes of POVL in spine procedures are the two different forms of ischemic optic neuropathy: anterior ischemic optic neuropathy and posterior ischemic optic neuropathy, accounting for 89% of the cases. Retinal ischemia, cortical blindness, and posterior reversible encephalopathy are also observed, but in a small minority of cases. A recent multicenter case control study has identified risk factors associated with ischemic optic neuropathy for patients undergoing prone spinal fusion surgery. These include obesity, male sex, Wilson frame use, longer anesthetic duration, greater estimated blood loss, and decreased percent colloid administration. These risk factors are thought to contribute to the elevation of venous pressure and interstitial edema, resulting in damage to the optic nerve by compression of the vessels that feed the optic nerve, venous infarction or direct mechanical compression. This review will expand on these findings as well as the recently updated American Society of Anesthesiologists practice advisory on POVL. There are no effectivetreatment options for POVL and the diagnosis is often irreversible, so efforts must focus on prevention and risk factor modification. The role of crystalloids versus colloids and the use of α-2 agonists to decrease intraocular pressure during prone spine surgery will also be discussed as a potential preventative strategy. | Travis J Nickels Mariel R Manlapaz Ehab Farag | 2014 | World Journal of Orthopedics2014，5，2： | 7 |
| 4 | 认知神经心理学理论研究与失语症治疗的关系显示文摘该文介绍了词语产出的加工阶段以及在获得性语言障碍病人(失语症病人)身上这些阶段可能的损伤情况。文中特别介绍了两例词汇提取障碍病人的治疗,这不仅有助于了解该障碍,更有助于了解其潜在的理论问题。第一个案例关注使用不同的任务治疗词汇提取障碍,评估治疗效果,探究任务产生作用的原理。第二个案例使用词汇提取障碍的治疗方法探讨一个充满争议的问题:同音词(如,pour/paw)在词汇产出过程中是共用一个语音表征还是各自单独表征。 | Lyndsey Nickels | 2008 | 心理科学进展2008，16，1： | 6 |
| 5 | 经食管心房调搏1026例结果分析显示文摘目的探讨多功能心脏电生理刺激记录仪的临床应用。方法应用多功能心脏电生理刺激记录仪(DF-5A型)对1026例被检查者(包括2008年6月至2013年6月在苏州大学第一附属医院门诊、急诊及病房等就诊者),行经食管心房调搏术(TEAP),其中男性362例,年龄:15~85岁。结果 1026例被检查中,912例因"阵发性胸闷心悸不适"行TEAP,695例拟诊阵发性室上性心动过速(PSVT);217例拟诊窦房结功能不良,67例因PSVT发作,为中止PSVT;另有47例因不能配合而拒绝TEAP。695例拟诊PSVT者中,TEAP诱发并终止PSVT 278例(房室结双165例,旁道113例);64例被检查者存在房室结双径路,但未能诱发PSVT。217例拟诊窦房结功能不良者,仅20例符合窦房结功能不良,且大多为老年人。53例被检查者在检查过程中分别出现短阵房速、房扑或房颤,其他被检查者为见明显异常。结论 DF-5A型多功能心脏电生理刺激记录仪给临床医生提供了有效、安全和方便的诊疗措施。 | 刘丹 惠杰 刘明 胡小武 NICKEL HUSSAIN 董苏 金林根 邬小玫 方祖祥 蒋文平 | 2014 | 临床心电学杂志2014，23，1： | 6 |
| 6 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 7 | 论保险公司营销渠道设计与创新显示文摘中国已经加入世界贸易组织,我国的保险市场已经全面对外开放。毫无疑问,这既给民族保险公司带来了无限机遇和发展契机,又使我国的保险市场面临十分激烈的竞争。目前,我国保险业有很多领域需要改革完善,其中由于传统的营销方式已显现单一、老化等弊端,开始难以满足当今保险市场发展的需要,因而保险营销改革和营销渠道建设与创新尤其显得紧迫。 | Nickel Andreas 许闲 | 2005 | 保险职业学院学报2005，19，2： | 4 |
| 8 | 用恒电流法研究Fe(Ⅲ)EDTA对银的氧化过程显示文摘本文采用银旋转圆盘电极,在氟离子、溴离子、碘离子以及其他照相辅加剂存在下对Fe(Ⅲ)EDTA氧化金属银的过程进行了研究,以恒电流法做为检测手段,初步探讨了Fe(Ⅲ)EDTA络合物对金属银漂白过程机理。实验揭示了各种卤离子在Fe(Ⅲ)EDTA对银的氧化过程中的行为。pH和Fe(Ⅲ)EDTA浓度对该氧化还原反应的影响,以及某些含有巯基的化合物对Fe(Ⅲ)EDTA氧化反应的加速作用机理。 | 刘春艳 Ulrich Nickel | 1990 | 感光科学与光化学1990，8，1： | 4 |
| 9 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 10 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 11 | Rethinking Indivisibility: Towards A Theory of Supporting Relations between Human Rights显示文摘 | Nickel James W | 2008 | Human Rights Quarterly2008，，4： | 2 |
| 12 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 13 | Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis 显示文摘 | Quigiey HA Nickells RW Kerrigan LA | 1995 | Invest Ophthalmol Vis Sci1995，36，5： | 2 |
| 14 | Ultrasonic waste activated sludge disintegration for improving anaerobic stabilization显示文摘 | A Tiehm K Nickel M Zellhorn U Neis | 2001 | Water Research2001，，8： | 2 |
| 15 | Retinal ganglion cells death in experimental glaucoma and after axotomy occurs by apoptosis 显示文摘 | Quigley HA Nickells RW Kerrigan LA | 1995 | Invest Ophthalmol Vis Sci1995，36，： | 2 |
| 16 | A new signal adaptive approach to positive time- frequency distributions with suppressed interference terrns显示文摘 | Nickel R M Sang T H Williams W J | 1998 | ICASSP1998，，： | 1 |
| 17 | A silver colloid produced by reduction with hydrazine as support for highly sensitive surface-enhanced Raman spectroscopy显示文摘 | Nickel U Castell A Poppl K | 2000 | Langmuir2000，16，23： | 1 |
| 18 | Increased pregnancy rates after uhralong postoperative therapy with gonadotropin releasing hormone analogs in patients with endometriosis 显示文摘 | Rickes D Nickel I Kropf S | 2002 | Fertil Steril2002，78，4： | 1 |
| 19 | Visual recognition of pointing gestures for human-robot interaction显示文摘 | Nickel K Stiefelhagen R | 2007 | Image and Vision Computing2007，25，12： | 1 |
| 20 | Unemployment and Labor Market Rigidities: Europe Versus North America显示文摘 | Nickell S | 1997 | The Journal of Economic Perspectives1997，11，3： | 1 |
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