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| 1 | The Multifaceted Roles of HY5 in Plant Growth anc Development显示文摘伸长的 HYPOCOTYL5 (HY5 ) , bZIP 抄写因素家庭的一个成员,禁止胚轴生长和侧面的根开发,并且在 Arabidopsis 以一种轻依赖者的方式支持颜料累积。关于它在象荷尔蒙那样的不同过程的角色的最近的研究,滋养的、不能生活的应力(abscisic 酸,盐,冷) ,并且表明小径的反应的氧种类清楚地把 HY5 放在一个 transcriptional 网络中心的中心。HY5 调整很多基因的抄写由对 cis 规章的元素直接有约束力。最近, HY5 也被显示了激活它的自己的表示在下面可见并且 UV-B 光。而且, HY5 充当从射击搬到根支持硝酸盐举起和根生长的一个信号。这里,我们在植物开发的多样的方面在 HY5 研究上考察最近的进展并且加亮需要在不久的将来在植物发信号并且在以外为它的函数的完全的理解被探讨的仍然待研究的问题。 | Sreeramaiah N. Gangappa Javier F. Botto | 2016 | Molecular Plant2016，9，10： | 51 |
| 2 | Responses of Soil Microbial Community Structure and Diversity to Agricultural Deintensification显示文摘Using a scheme of agricultural fields with progressively less intensive management (deintensification), different manage- ment practices in six agroecosystems located near Goldsboro, NC, USA were tested in a large-scale experiment, including two cash-grain cropping systems employing either tillage (CT) or no-tillage (NT), an organic farming system (OR), an integrated cropping system with animals (IN), a successional field (SU), and a plantation woodlot (WO). Microbial phos- pholipid fatty acid (PLFA) profiles and substrate utilization patterns (BIOLOG ECO plates) were measured to examine the effects of deintensification on the structure and diversity of soil microbial communities. Principle component analyses of PLFA and BIOLOG data showed that the microbial community structure diverged among the soils of the six systems. Lower microbial diversity was found in lowly managed ecosystem than that in intensive and moderately managed agro- ecosystems, and both fungal contribution to the total identified PLFAs and the ratio of microbial biomass C/N increased along with agricultural deintensification. Significantly higher ratios of C/N (P < 0.05) were found in the WO and SU systems, and for fungal/bacterial PLFAs in the WO system (P < 0.05). There were also significant decreases (P < 0.05) along with agricultural deintensification for contributions of total bacterial and gram positive (G+) bacterial PLFAs. Agricultural deintensification could facilitate the development of microbial communities that favor soil fungi over bacteria. | ZHANG Wei- Jian RUI Wen-Yi C. TU H. G. DIAB F. J. LOUWS J. P. MUELLER N. CREAMER M. BELL M.G. WAGGER S. HU | 2005 | Pedosphere2005，15，4： | 29 |
| 3 | Schistosoma japonicum egg antigens stimulate CD4(+) CD25(+) T cells and modulate airway inflammation in a murine model of asthma显示文摘 | Yang, J. H. Zhao, J. Q. Yang, Y. F. Zhang, L. Yang, X. Zhu, X. Ji, M. J. Sun, N. X. Su,C. | 2007 | 南京医科大学学报(自然科学版)2007，27，4： | 25 |
| 4 | GIS-based risk analysis of debris flow:an application in Sichuan,southwest China显示文摘Debris flow is a serious geologic hazard in China.It is estimated that nationally debris flows cause up to 2 billion RMB(250 million US$) in damages and 300-600 deaths and injuries annually.To mitigate debris flow hazards,it is necessary to map,model,and identify zones of debris flow hazards and vulnerability as to inform the local people about the potential risk with a geographic information system.This research presents a regional scale case study modeling debris flow risk(hazard and vulnerability) in Sichuan Province,Southwestern China.In this area,3,290 debris flows have been identified and the spatial-temporal distribution and activity characteristics of them have been documented.Based on the available meteorological data,a Digital Elevation Model with the rate of 1:250,000 and a regional geological map,the 24-hr rainfall threshold(y) for debris flow occurrence is closely related(significant at 99% confidence level) to the index(x) defined using a geology factor(rock hardness:a) and a topographical factor(channel gradient:d) where y = 21 + 10200 / x,in which x = 2.7 × ea + 1000 × d.The discipline is constructive in developing the rainfall threshold for debris flow activity in remote mountainous areas that lack data.For a given watershed,a four-level debris flow hazard map is developed by comparing the rainfall threshold to the design rainfall intensities with 50-,20-,and 5-year average recurrence intervals,respectively.The degree of debris flow vulnerability is determined by the watershed socio-economic conditions.A four-class debris flow risk map,at the final phase of the research,is generated by combining debris flow hazards and vulnerability.With the debris flow risk assessment,the Sichuan Province is classified into the slight,moderate,severe and very severe regions,which accounts for 36%,19%,20% and 25% of total area respectively. | B. F. DI N. S. CHEN P. CUI Z. L. LI Y. P. HE Y. C. GAO | 2008 | International Journal of Sediment Research2008，23，2： | 19 |
| 5 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 6 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 7 | 伴有脑肿胀的大脑和小脑梗死的管理推荐意见美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景和目的关于缺血性卒中后脑肿胀患者的最佳管理方案,仍有许多尚未确定的问题。需要制定相关指南来指导如何处理这种严重并发症,如何提供最佳的综合性神经科和内科治疗,以及在患者病情恶化时如何与面临外科干预复杂决策的家属进行良好的沟通。本科学声明为大脑或小脑半球缺血性卒中伴脑肿胀的患者提供了早期的管理方案。方法写作组利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有证据进行总结并指出与当前知识水平的差距。写作组通过对MEDLINE、EMBASE和Web of Science数据库进行医学文献计算机检索(最后检索时间为2013年3月,研究对象为成年人)回顾最相关的文献。在美国心脏协会(American Heart Association,ARIA)框架背景下对证据进行组织,根据AHA/美国心脏病学学会基金会以及AHA卒中委员会的证据强度分级方案进行分类。这份声明经过AHA内部的广泛同行评议。结果已有适用于由缺血性梗死引起的半球(累及整个大脑中动脉供血区或更大范围)和小脑(累及小脑后下动脉或小脑上动脉供血区)肿胀的临床标准。幕上半球缺血性卒中伴脑肿胀发生恶化的临床表现包括新发意识障碍或意识障碍加重、脑性上睑下垂以及瞳孔大小变化。在小脑梗死伴肿胀患者中,意识水平下降是脑干受压的结果,因此可能出现早期角膜反射丧失和瞳孔缩小。应制定标准化定义以促进多中心和基于人群的发病率、患病率、危险因素和转归研究。脑肿胀高危患者的识别应包括临床和神经影像学资料。如果大面积卒中患者有必要进入全面复苏状态,则需要收入具备神经监护功能的病房。这些患者最好被收入由技术熟练和经验丰富的医生(如神经重症监护医生或神经血管科医生)负责的重症监护室或卒中单元。综合性医疗管理包括气道管理和机械通气、血压控制、液体管理以及血糖和体温控制。在幕上半球缺血性卒中伴肿胀患者中,不需行常规颅内压监测或脑脊液引流,但神经功能继续恶化的患者应考虑行去骨瓣减压和硬脑膜切开术。去骨瓣减压术在≥60岁的患者中的疗效尚不确定。在神经功能恶化的小脑卒中伴肿胀患者中,应行枕骨下颅骨切除和硬脑膜切开术。当应用脑室造瘘术缓解小脑梗死后梗阻性脑积水时,应同时行枕骨下颅骨切除术以防小脑向上移位导致的病情恶化。幕上半球梗死伴肿胀患者可获得令人满意的转归,但即使行去骨瓣减压术,仍有1/3的患者会遗留严重残疾和完全生活依赖。多数小脑梗死患者在术后能获得可接受的功能转归。结论大脑和小脑梗死伴肿胀是需要立即给予专业神经重症监护、并常需要进行神经外科干预的危重情况。去骨瓣减压术是很多患者的必然治疗选择,经过选择的患者能从中受益匪浅,尽管他们可能会遗留残疾,但仍可生活自理。 | Eelco F. M. Wijdicks Kevin N. Sheth Bob S. Carter David M. Greer Scott E. Kasner W. Taylor Kimberly Stefan Schwab Eric E. Smith Rafael J. Tamargo Max Wintermark 王玉琴 牛牧 柯开富 | 2014 | 国际脑血管病杂志2014，22，4： | 11 |
| 8 | Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity显示文摘这评论研究的目的是阐明效果那磷酸二酯酶 5 (PDE5 ) 禁止者在精子上施加活动性, capacitation 过程并且在他们使肥沃的能力上卵母细胞。第二个送信人系统象 cAMP/adenylate cyclase (交流) 那样系统和 cGMP/guanylate cyclase (GC ) 系统看起来调整精子功能。intracytosolic 营地的增加的层次导致精子活动性和生存能力的改进。由氮的氧化物的低剂量的 GC 的刺激(没有) 导致精子活动性的改进或维护,而更高的集中在精子参数上有不利效果。几在活体内和在试管内研究被执行了以便检验 PDE5 禁止者是否断然或否定地影响精子参数和精子使肥沃能力。这些研究的结果是争论的。一些这些研究不在从与 PDE5 禁止者被对待的人收集的精子的活动性,生存能力,和形态学上表明 PDE5 禁止者的重要效果。在另一方面,几研究在精子活动性上表明 PDE5 禁止者的积极效果在活体内和在试管内。sildenafil 柠檬酸盐的在试管内研究随在除 PDE5 以外的 PDE 对碘氧基苯甲醚上建议 sildenafil 柠檬酸盐的一个禁止的行动的细胞内部的营地的增加在精子活动性上表明 stimulatory 效果。在另一方面, tadalafil 的行动看起来在 PDE11 上与这混合物的禁止的效果被联系。在在一个每日的基础与 vardenafil 对待的人的在活体内研究每精液,量的精子活动性,和质的精子活动性表明了精子的一个显著地更大的全部的数字;vardenafil 管理提高前列腺的能分泌的功能并且随后增加精子的质、量的活动性,这被建议了。PDE5 禁止者在精子参数上施加的效果可以导致帮助繁殖技术(艺术) 的结果的改进程序。在未来 PDE5,禁止者可能为男不孕的缓和用作附属物 therapeutical 代理人。 | F. Dimitriadis D. Giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.Tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis | 2008 | Asian Journal of Andrology2008，10，1： | 11 |
| 9 | WSA工艺在煤气化超高硫回收中的应用显示文摘介绍托普索公司WSA工艺在Rentech公司煤气化项目废气净化中的应用。该技术的主要设备是WSA冷凝器。与传统硫酸生产技术相比,WSA工艺所需设备较少,因此投资、操作和维修费用较低。WSA装置可脱除原料气中高达99.98%的硫化合物。该技术可确保Rentech公司在满足严格排放要求的同时生产有价值的商品硫酸,并且输出高压过热蒸汽来解决整个煤气化联合装置的能量平衡问题。 | B. Johnson C. T. Lankford F. E. Jensen N. R. Udengaard 李珊(译) | 2008 | 硫酸工业2008，，3： | 8 |
| 10 | Anaerobic Removal of Trace Organic Contaminants in Sewage Sludge: 15 Years of Experience显示文摘Trace organic contaminants (TOCs) correspond to a broad range of molecules generated either directly or indirectly by human activity. Even though TOCs are found at low concentrations in the environment, they often accumulate by biomagnification and bioaccumulation into biological organisms and cause irreversible damages in biological systems through direct or indirect toxic effects such as endocrine disruption and tumour initiation. This manuscript presents the main findings of over fifteen years of research focusing on biological removal of various TOCs found in sewage sludge from urban treatment plants. A special focus of the research was made on microbial processes in complex anaerobic ecosystems. Four families of compounds mostly retrieved in urban plants were studied: the polycyclic aromatic hydrocarbons (PAHs), the polychlorobiphenyls (PCBs), the phthalic acid esters (PAEs), and the nonylphenol ethoxylates (NPEs). It was observed that the microbial capability for removing low amounts of TOCs required a long adaptation time and was often limited by the bioavailability of these compounds. In fact, the overall biodegradation resulted from the numerous interactions existing between the matrix (organic matter) and the microbial ecosystems according to the physico-chemical sorption properties of these compounds. Mechanistic aspects were also tackled in depth and specific models were developed for better understanding the network of interactions between TOCs, microorganisms, and organic matter. These findings could be extrapolated to other ecosystems such as soils and sediments. Finally, it was shown that microbial cometabolism was essential for TOC removal, and the concept of bioavailability was not only dependent on the nature, the level, and the sorption properties of TOCs but was also strongly dependent on the nature and the concentration of the sludge organic matter. Specific parameters were proposed for better evaluating the fate of TOCs in microbial anaerobic processes and technological solutions for efficient removal of these compounds were also proposed. | M. BARRET L. DELGADILLO-MIRQUEZ E. TRABLY N. DELGENES F. BRAUN G. CEA-BARCIA J. P. STEYER D. PATUREAU | 2012 | Pedosphere2012，22，4： | 8 |
| 11 | 利用地震噪声预报火山喷发显示文摘火山喷发之前岩浆压力会增大,导致火山筑积物的膨胀(Patanèet al,2003)。火山膨胀引起的地面形变可以通过各种技术手段来揭示,比如利用航天雷达干涉仪(Massonnetet al,2001)或应变与倾斜仪(Peltieret al,2005)。实时监测这种过程能为我们预报火山喷发提供有用的信息。然而,在某些情况下火山筑积物的膨胀可发生在地表上无法检测到任何效应的深度上,因而尽管付出了相当大的努力(Ratdomopurboand Poupinet,1995;Snieder and Hagerty,2004),但对于火山内部变化的监测还是证明是十分困难的。本文我们利用超过18个月间期记录到的地震噪声的性质说明,通过测量0.05%这种非常小的相对地震波速微扰可以连续监测到富尔奈斯火山的内部变化。火山喷发前几个星期地震波速的降低表明,火山筑积物在喷发之前的膨胀,可能是由于岩浆压力增大所致。这种火山筑积物膨胀的记录能力,应能提高我们预报火山喷发及其强度和潜在环境影响的能力。 | F. Brenguier N. M. Shapiro M. Campillo V. Ferrazzini Z. Duputel O. Coutant A. Nercessian 李宜晋 | 2008 | 世界地震译丛2008，，2： | 8 |
| 12 | Arc Power Limit and Distribution on the Large Negative Ion Source Based on JT-60 NNBI | LEI Guangjiu N. Umeda M. Kawai T. Yamamoto M. KuriyamaT. Ohga N. Ebisawa T. Yamazaki M. Kusaka K. KikuchiS. Hikida K. Usui M. Kazawa S. Numazawa K. MogakiA.Honda F. Satoh S. Norio K. Ooshima 1) Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka-gun, Ibraraki-ken 311-0193, Japan. | 2002 | 中国核科技报告2002，，1： | 7 |
| 13 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 14 | K-ATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured Astrocytes显示文摘Increasing evidence, including from our laboratory, has revealed that opening of ATP sensitive potassium channels(K-ATP channels) plays the neuronal protective roles both in vivo and in vitro. Thus K-ATP channel openers(KCOs) have been proposed as potential neuroprotectants. Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats. Since glutamate transporters(GluTs) of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes, the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes. The results showed that nonselective KCO pinacidil, selective mitochondrial KCO diazoxide, novel, and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake, except for the sarcolemmal KCO P1075. Moreover pinacidil, diazoxide, and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+). These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate. Furthermore, either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species (ROS) and phosphorylation of protein kinases C(PKC). These findings are the first to demonstrate that activation of K-ATP channel, especially mitochondrial K-ATP channel, improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation. Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection. | Sun, X. L. Zeng, X. N. Zhou, F. Dai, C. P. Ding, J. H. Hu, G. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Neuropharmacol Lab,Nanjing 210029,Jiangsu,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 7 |
| 15 | Field trial of an HTS filter system on a CDMA base station显示文摘This paper presents the field trial results of a high temperature superconductor filter system (HTSFS) in a code division multiple access (CDMA) mobile communication base station (BTS) in Tangshan, China. The center frequency of the HTSFS is 830 MHz with 1.4% fractional bandwidth. The noise figure (NF) of the HTSFS, including connectors and cables, is 0.8 dB. The field trial results show that after the HTSFS was installed in the receiver front-end of a CDMA base station, the transmitting power of handset was decreased by 3.1 dB on average. Up to now, the HTSFS has been running steadily in the base station for more than 22 months, demonstrating the reliability and stability of the system. | YIN ZheSheng WEI Bin CAO BiSong WANG Xin GUO XuBo ZHANG XiaoPing GAO LongMa PIAO YunLong ZHU MaFeng LIANG Yong WANG Fan H. PIEL B. AMINOV F. AMINOVA M. GETTA S. KOLESOV A. KNACK N. PUPETER D. WEHLER | 2007 | Chinese Science Bulletin2007，52，2： | 7 |
| 16 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 17 | Clinical Evaluation of a Ten‐Day Regimen with E someprazole, M etronidazole, A moxicillin, and C larithromycin for the Eradication of H elicobacter pylori in a High Clarithromycin Resistance Area显示文摘 | Sotirios D. Georgopoulos Elias Xirouchakis Beatriz Martinez‐Gonzalez Dionyssios N. Sgouras Charikleia Spiliadi Andreas F. Mentis Fotini Laoudi | 2013 | Helicobacter2013，，6： | 6 |
| 18 | Single-operator, single-session EUS-guided anterograde cholangiopancreatography in failed ERCP or inaccessible papilla显示文摘 | Janak N. Shah Fernando Marson Frank Weilert Yasser M. Bhat Thai Nguyen-Tang Richard E. Shaw Kenneth F. Binmoeller | 2012 | Gastrointestinal Endoscopy2012，，1： | 5 |
| 19 | A short-chain α-neurotoxin from Naja naja atra produces potent cholinergic-dependent analgesia显示文摘Objective To investigate the analgesia induced by cobrotoxin (CT) from venom of Naja naja atra, and the effects of atropine and naloxone on the antinociceptive activity of CT in rodent pain models. Methods CT was administered intraperitoneally (33.3,50,7μg/kg) , intra-cerebral venticularly (2.4μg /kg) or microinjected into periaque-ductal gray (PAG,1.2μg /kg). The antinociceptive action was tested using the hot-plate test and the acetic acid writhing test in mice and rats. The involvement of cholinergic system and the opioid system in CT-induced analgesia was examined by pretreatment of animals with atropine (0.5mg/kg, im or 10mg/kg, ip) or naloxone (3mg/kg,ip) . The effect of CT on motor activity was tested using the Animex test. Results CT (33.3,50 and 75μg/kg,ip) exhibited a dose-dependent analgesic action in mice as determined with hot-plate test and acetic acid writhing test. In the mouse acetic acid writhing test, the intra-cerebral ventricle administration of CT 2.4μg/kg (1/23th of a systemic dose) produced marked analgesic effects. Microinjection of CT 1.2μg/kg (1/46th of systemic dose) into the PAG also elicited a robust analgesic action in the hot-plate test in rats. Atropine at 0.5 mg/kg (im) or naloxone at 3 mg/kg (ip) failed to block the analgesic effects of CT, but atropine at 10 mg/kg (ip) did antagonize the analgesia mediated by CT in the mouse acetic acid writhing test. At the highest effective dose of antinociception (75μg/kg) , CT did not change the spontaneous mobility of mice. Conclusion These results suggest that CT from Naja naja atra venom has analgesic effects. Central nervous system may be involved in CT' analgesic effects and the PAG may be the primary central site where CT exerts its effects. The central cholinergic system but not opioid system appears to be involved in the antinociceptive action of CT. | Hui-Ling ZHANG Rong HAN Zhen-Lun GU Zhi-Xing CHEN Bo-Wen CHEN Paul F. Reid Laurence N. Raymond Zheng-Hong QIN | 2006 | Neuroscience Bulletin2006，22，2： | 5 |
| 20 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
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