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| 1 | Dimensions of hepatocellular carcinoma phenotypic diversity显示文摘Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying 'clinically-friendly' molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the remaining challenges to translate our cognitive corpus into patient diagnosis and allocation to therapeutic options. | Romain Désert Natalia Nieto Orlando Musso | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 2 | Detection of Zika virus in saliva 显示文摘 | MUSSO D ROCHE C NHAN TX | 2015 | J Clin Virol2015，68，： | 1 |
| 3 | Detection of Zika virus in saliva显示文摘 | Musso D Roche C Nhan TX | 2015 | J Clin Virol2015，，68： | 1 |
| 4 | Potential for Zika virustransmission through blood transfusion demonstrated during anoutbreak in French Polynesia, November 2013 to February 2014显示文摘 | Musso D Nhan T Robin E | 2014 | EuroSurveill2014，19，20： | 1 |
| 5 | Isolation of blood brone mycobacterium avium by using BACTEC 9000MB system and comparion with a solid - culture system显示文摘 | Jacomo V Musso D Gevaudan MJ | 1998 | J Clin Microbiol1998，36，： | 1 |
| 6 | Isolation of blood - borne mycobacterium avium by using the nonradioactive BACTEC 9000 MB system and comparison with a solid -culture system显示文摘 | Jacomo V Musso D Gevaudan M J | 1998 | J Clin Microbiol1998，36，12： | 1 |
| 7 | Potential sexual transmission ofZika virus显示文摘 | Musso D Roche C Robin E e t al | 2015 | Emerg Infect Dis2015，2，2： | 1 |
| 8 | Rapid spread of emer- ging Zika virus in the Pacific area显示文摘 | Musso D Nilles EJ Cao-Lormeau VM | 2014 | Clin Microbiol Infect2014，20，： | 1 |
| 9 | Obstructive sleep apnea-hypopnea syndrome and normlcoholic fatty liver disease: emerging evidence and mecha- nisms显示文摘 | Musso G Olivetti D | 2012 | Semin Liver Dis2012，32，1： | 1 |
| 10 | Role of frozen section histology in diagnosis of infection during revision arthroplasty显示文摘 | MUSSO A D MOHANTY K SPENCER JONES R | 2003 | Postgrad Med J2003，79，936： | 1 |
| 11 | Amyloid in bone marrow smears of patients affected by multiple myeloma显示文摘 | Fara Petruzziello Pio Zeppa Lucio Catalano Immacolata Cozzolino Giuseppe Gargiulo Pellegrino Musto Fiorella D’Auria Vincenzo Liso Rita Rizzi Nadia Caruso Catello Califano Eugenio Piro Maurizio Musso Vincenza Bonanno Antonietta Pia Falcone Salvatore Tafuto | 2010 | Annals of Hematology2010，，5： | 1 |
| 12 | Zika virus infection complicated by GuillainBarrésyndrome-case report,French Polynesia,December 2013显示文摘 | Oehler E Watrin L Larre P Leparc Goffart I Lastere S Valour F Baudouin L Mallet H Musso D Ghawche F | 2014 | Euro Surveill2014，19，20： | 1 |
| 13 | Zika virus: follow- ing the path of dengue and chikungunya? 显示文摘 | Musso D Cao-Lormeau VM Gubler DJ3 | 2015 | Lancet2015，386，： | 1 |
| 14 | Potcntial for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014 显示文摘 | Musso D Nhan T Robin E | 2014 | Euro Surveill2014，19，20： | 1 |
| 15 | Potential for Zika virus trans- mission through blood transfusion demonstrated during an out- break in French Polynesia, November 2013 to February 2014 显示文摘 | Musso D Nhan T Robin E | 2014 | Euro Surveill2014，19，20： | 1 |
| 16 | Potential sexual transmission of Zika virus显示文摘 | Musso D Roche C Robin E Nhan T Teissier A Cao-Lormeau VM | 2015 | Emerg Infect Dis2015，21，2： | 1 |
| 17 | Zika virus transmission from French Polynesia to Brazil显示文摘 | Musso D | 2015 | Emerg Infect Dis2015，21，： | 1 |
| 18 | Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase 显示文摘 | Khabnadideh S Pez D Musso A | 2005 | Bioorg Med Chem2005，13，7： | 1 |
| 19 | Potential sexual transmission of Zika virus显示文摘 | Musso D Roche C Robin E et ol | 2015 | Emerg Infect Dis2015，21，2： | 1 |
| 20 | Potential sexual transmission of Zika virus显示文摘 | Musso D Roche C Robin E | 2015 | Emerg Infect Dis2015，21，2： | 1 |
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