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189篇 您的检索式：作者名="Mulder D"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification显示文摘	Frijters C T M J Eikelboom D H Mulder A	1997	Water Science Technology1997，36，1：	1
3	Design of a haptic gas pedal for active car-fol- lowing support显示文摘	MULDER M ABBINK D A VAN PAASSEN M M	2011	IEEE Transactions on Intelligent Transportation Systems2011，12，1：	1
4	The role of organic matter in controlling aluminum solubility in acidic mineral soil horizons 显示文摘	Berggren D Mulder J	1995	Geoehim Cosmochim Acta1995，59，：	1
5	Cardiopulmonary resuscitation:Errors- made by prehospital emergency medical personnel显示文摘	Liberman M Lavoie A Mulder D	1999	Resuscitation1999，42，1：	1
6	Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification显示文摘	Eikelboom D H Mulder A	1997	Water Science and Technology1997，36，：	1
7	Effect of platelet-ricb plasma on bone regeneration in dentistry: a systematic review 显示文摘	Plachokova AS Nikolidakis D Mulder J	2008	Clinic Oral Implants Resear2008，19，6：	1
8	Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review显示文摘	Plachokova AS Nikolidakis D Mulder J	2008	Clin Oral Implants Res2008，19，6：	1
9	Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification 显示文摘	FRIJTERS C T M J EIKELBOOM D H MULDER A	1997	Water Science Technology1997，36，1：	1
10	Short-term effects of polyphenol-rich black tea on blood pressure in men and women显示文摘	Hodgson JM Woodman RJ Puddey IB Mulder T Fuchs D Croft KD		0，，：	1
11	A survey of compu- tational steering environments 显示文摘	Mulder J D van Wijk J J van Liere R	1999	Future Generation Computer Systems1999，15，1：	1
12	The effect of aggressive versus conventional lipid-lowering therapy on markers of inflammatory and oxidative stress 显示文摘	Mulder D J van Haelst PL Wobbes MH	2007	Cardiovasc Drugs Ther2007，21，2：	1
13	Recombinant hor- mones : Molecular biology and biochemistry of humart recombinant follicle stimulating hormone ( Puregon ) 显示文摘	Olijve W Boer W D Mulders J W M	1996	Molecular Human Reproduction1996，2，5：	1
14	Effect of platelet-rich plasma on bone regeneration in dentistry:A sys- tematic review 显示文摘	Plachokova AS Nikolidakis D Mulder J	2008	Clin Oral Implants Res2008，19，6：	1
15	Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review 显示文摘	Plachokova AS Nikolidakis D Mulder J	2008	Clin Oral Implants Res2008，19，6：	1
16	Acute tracheoesophageal burst injury after blunt chest trauma: case report and review of the literature 显示文摘	MARTEL G AL-SABTI H MULDER D S	2007	J Trauma2007，62，1：	1
17	Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase 显示文摘	Holst L S Langin D Mulder H	1996	Genomies1996，35，3：	1
18	Localization of the human gene for aquaporin 3 ( AQP3 ) to chromosome 9, region p21--> p12, using fluorescent in situ hybridization 显示文摘	Mulders SM Olde Weghuis D van Boxtel JA	1996	Cytogenet Cell Genet1996，72，4：	1
19	The role of organic matter in controlling aluminum solubility in acidic mineral soil horizons 显示文摘	Berggron D Mulder J	1995	Geochim Cosmochim Acta1995，59，20：	1
20	Hyperactivity in the auditory midbrain after acoustic trauma:dependence on cochlear activity 显示文摘	Mulders WH Robertson D	2009	Neuroscience2009，13，02：	1

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