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| 1 | Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance显示文摘BACKGROUND: Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic interventions.DATA SOURCES: The data of mouse hepatic models and relevant human liver diseases presented in this review are systematically collected from Pub Med, Science Direct and the Web of Science databases published in English. RESULTS: The hepatotoxic liver injury in mice induced by the metabolites of CCl4, acetaminophen or alcohol represent necrotic cell death with activation of cytochrome pathway, formation of reactive oxygen species(ROS) and mitochondrial damage. The Fas or TNF-α induced apoptotic liver injury was dependent on activation of caspases, release of cytochrome c and apoptosome formation. The Con A-hepatitis demonstrated the involvement of TRAIL-dependent necrotic/necroptotic cell death with activation of RIPK1/3. The α-Gal Cer-induced liver injury was mediated by TNF-α. The LPS-induced hepatitis involved TNF-α, Fas/Fas L, and perforin/granzyme cell death pathways. The MHV3 or Poly(I:C) induced liver injury was mediated by natural killer cells and TNF-α signaling. The necrotic ischemia-reperfusion liver injury was mediated byhypoxia, ROS, and pro-inflammatory cytokines; however, necroptotic cell death was found in partial hepatectomy. The crucial role of immune cells and cell death mediators in viral hepatitis(HBV, HCV), drug-induced liver injury, non-alcoholic fatty liver disease and alcoholic liver disease in human were discussed.CONCLUSIONS: The mouse animal models of hepatitis provide a parallel approach for the study of human liver pathology. Blocking or stimulating the pathways associated with liver cell death could unveil the novel therapeutic strategies in the management of liver diseases. | Hilal Ahmad Khan Muhammad Zishan Ahmad Junaid Ali Khan Muhammad Imran Arshad | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 24 |
| 2 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 3 | Breeding for pre-harvest sprouting resistance in bread wheat under rainfed conditions显示文摘Pre-harvest sprouting in wheat is the germination of seeds within the spikes when rains occur after or during grain ripening, which occurs commonly in the barani tract of Pakistan. Therefore, 10 cultivars and five advanced lines of spring bread wheat were evaluated for pre-harvest sprouting resistance. After natural rainfall,seeds were immediately collected from the wet spikes and tested for germinating ability. Three different germination tests were applied to hand-threshed seed:(1) spikes threshed on the day of sampling and germination tested immediately,(2) spikes threshed on the day of sampling and germination tested 1 week later, and(3) spikes threshed 1 week after sampling and germination test immediately after threshing. Seeds and spikes kept for 1 week were place on blotting paper at room temperature.Cultivars BARS-09, 09 FJ17, Doukkala-12, NARC-09 and Ouassou-20 exhibited higher sprouting resistance while other genotypes were susceptible to pre-harvest sprouting in each of the three tests. A diallel crossing was conducted with six susceptible and two resistant genotypes to assess the genetic behavior of pre-harvest sprouting resistance.The combining ability(CA) demonstrated a higher proportion of additive genetic effects for sprouting resistance, because of higher variance of general and specific CA for both parameters under study. Doukkala-12 and BARS-09 showed increased pre-harvest sprouting resistance in their F1 descendants. | Muhammad ZEESHAN Waheed ARSHAD Muhammad Imran KHAN Shiraz ALI Ali NAWAZ Amina BATOOL Muhammad TARIQ Muhammad Imran AKRAM Muhammad Amjad ALI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 1 |
| 4 | COVID-19 and comorbidities of hepatic diseases in a global perspective显示文摘The worldwide outbreak of coronavirus disease 2019(COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. Epidemiological data evidenced that COVID-19 patients with altered liver function because of hepatitis infection and cholestasis have an adverse prognosis and experience worse health outcomes. COVID-19-associated liver injury is correlated with various liver diseases following a severe acute respiratory syndrome-coronavirus type 2(SARS-CoV-2) infection that can progress during the treatment of COVID-19 patients with or without pre-existing liver disease. SARS-CoV-2 can induce liver injury in a number of ways including direct cytopathic effect of the virus on cholangiocytes/hepatocytes, immune-mediated damage, hypoxia, and sepsis. Indeed, immediate cytopathogenic effects of SARSCoV-2 via its potential target, the angiotensin-converting enzyme-2 receptor, which is highly expressed in hepatocytes and cholangiocytes, renders the liver as an extra-respiratory organ with increased susceptibility to pathological outcomes. But, underlying COVID-19-linked liver disease pathogenesis with abnormal liver function tests(LFTs) is incompletely understood. Hence, we collated COVID-19-associated liver injuries with increased LFTs at the nexus of pre-existing liver diseases and COVID-19, and defining a plausible pathophysiological triad of COVID-19, hepatocellular damage, and liver disease. This review summarizes recent findings of the exacerbating role of COVID-19 in pre-existing liver disease and vice versa as well as international guidelines of clinical care, management, and treatment recommendations for COVID-19 patients with liver disease. | Aqsa Ahmad Syeda Momna Ishtiaq Junaid Ali Khan Rizwan Aslam Sultan Ali Muhammad Imran Arshad | 2021 | World Journal of Gastroenterology2021，27，13： | 1 |
| 5 | Effect of regional factor productivity on manufacturing sector: The case of Sino-Pak economic ties显示文摘Introduction:Economic ties and trade blocs increase the flow of trade between participating countries and lead to different levels of economic and structural changes.Case description:This paper focuses on the structure of industrial value-added between China and Pakistan,as the two countries recently launched the CPEC(China-Pakistan Economic Corridor)project.Discussion and evaluation:This study utilizes panel data from 1995 to 2015 to test certain factor effects on regional value-added through econometric analyses.The results show that each country has its own economic growth rate and market size that respond differently to industrial value-added production.Conclusion:Aggregate factor productivity at China is higher than in Pakistan but growth in factor productivity in the latter is higher than the former;similarly,the share of bilateral trade is higher in the case of Pakistan.Although each country responds differently to the new economic ties,the macroeconomic results support bilateral economic ties between them. | Muhammad Imran An HuSen Muhammad Kaleem Arshad Khan Bangash Nizam Ud Din Sobia | 2020 | Financial Innovation2020，6，1： | 1 |
| 6 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 7 | The circulation of unique reassortment strains of infectious bursal disease virus in Pakistan显示文摘Infectious bursal disease(IBD),caused by IBD virus(IBDV),is one of the most devastating and immunosuppressive diseases of the poultry and has been a constraint on the sustainable poultry production around the globe including Pakistan.While the disease is threatening the poulty industry,the nature of predominant strains of IBDV in Pakistan remained l-defined.In this study,an epidemiology survey was conducted in the main chicken-farming regions of Pakistan.The batch of Pakistan IBDVs genes simultaneously covering both VP1 and VP2 were amplified,sequenced,and analyzed.The unique segment-reassortant IBDVs(vv-A/Uniq-B),carrying segmentA from vvIBDV and segment B from one unique ancestor,were identifed as one important type of circulating strains in Pakistan.The data also discovered the characteristic molecular features of Pakistan IBDVs,which will contribute to scientific vaccine selection and effective prevention of the disease. | Altaf HUSSAIN WU Tian-tian FAN Lin-jin WANG Yu-long Farooq Khalid MUHAMMAD JIANG Nan GAO Li LI Kai GAO Yu-long LIU Chang-jun CUI Hong-yu PAN Qing ZHANG Yan-ping Asim ASLAM Khan MUTI-UR-REHMAN Muhammad Imran ARSHAD Hafiz Muhammad ABDULLAH WANG Xiao-mei QI Xiao-le | 2020 | Journal of Integrative Agriculture2020，19，7： | 1 |
| 8 | Tuning structural,electrical,dielectric and magnetic properties of Mg-Cu-Co ferrites via dysprosium(Dy^(3+))doping显示文摘In current research work,Dy3+substituted Mg0.5Cu0.25Co0.25Fe2-xDyxO4(0.0≤x≤0.04 with the step interval of 0.01)soft ferrites were synthesized by the sol-gel auto combustion method.The prepared samples were characterized by the techniques using X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),Fourier transform infrared(FTIR)spectroscopy,curre nt-voltage(Ⅰ-Ⅴ)measurement,LCR meter,vibrating sample magnetometer(VSM)and Raman.XRD data reveal that the average crystallite size is 49.71 nm and the lattice constant is 0.83703 nm for sample x=0.03.The non-uniform grain growth was demonstrated by micrographs and impurity-free elemental composition was observed from EDX analysis.The DC resistivity has an increasing and decreasing trend in ferromagnetic and paramagnetic regions with an increase in temperature.Moreover,the high resistivity is observed with the order of 1010Ω·cm,and the activation energy is 0.944 eV for samples x=0.03.The dielectric parameters including dielectric constant,dielectric losses,and impedance gradually decrease with the increase in frequency from 8 Hz to 8 MHz.The minimum dielectric loss at high frequency is found for sample x=0.03.The coercivity(Hc)and saturation magnetization(Ms)are found in the ranges of 520.82-544.02 Oe and 20.5841-21.1473 emu/g,respectively.These observations confirm that dysprosium(x=0.03)doped MCC-soft ferrites may be applicable in transformer cores,microwave absorbance,and telecommunication devices. | Maria Akhtar M.S.Hasan Nasir Amin N.A.Morley Muhammad Imran Arshad | 2024 | Journal of Rare Earths2024，42，1： | 0 |
| 9 | Financial Variables and Systematic Risk显示文摘 | Rashed Nawaz Waqar Ahmed Imran Sabeela Sabir Muhammad Arshad Tayyaba Rani Adnan Khan | 2017 | Chinese Business Review2017，16，1： | 0 |
| 10 | Molecular dynamics simulation of nanoscale surface diffusion of heterogeneous adatoms clusters显示文摘Molecular dynamics simulation employing the embedded atom method potential is utilized to investigate nanoscale surface diffusion mechanisms of binary heterogeneous adatoms clusters at 300 K, 500 K, and 700 K. Surface diffusion of heterogeneous adatoms clusters can be vital for the binary island growth on the surface and can be useful for the formation of alloy-based thin film surface through atomic exchange process. The results of the diffusion process show that at 300 K, the diffusion of small adatoms clusters shows hopping, sliding, and shear motion; whereas for large adatoms clusters(hexamer and above), the diffusion is negligible. At 500 K, small adatoms clusters, i.e., dimer, show almost all possible diffusion mechanisms including the atomic exchange process; however no such exchange is observed for adatoms clusters greater than dimer. At 700 K, the exchange mechanism dominates for all types of clusters, where Zr adatoms show maximum tendency and Ag adatoms show minimum or no tendency toward the exchange process. Separation and recombination of one or more adatoms are also observed at 500 K and 700 K. The Ag adatoms also occupy pop-up positions over the adatoms clusters for short intervals. At 700 K, the vacancies are also generated in the vicinity of the adatoms cluster,vacancy formation, filling, and shifting can be observed from the results. | Muhammad Imran Fayyaz Hussain Muhammad Rashid Muhammad Ismail Hafeez Ullah Yongqing Cai M Arshad Javid Ejaz Ahmad S A Ahmad | 2016 | Chinese Physics B2016，25，7： | 0 |
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