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| 1 | 急性脑梗死静脉溶栓后早期神经功能恶化与血清白蛋白水平的关系研究显示文摘目的探讨急性脑梗死静脉溶栓后早期神经功能恶化(END)与血清白蛋白水平的关系。方法收集2017年1月至2018年8月发病4.5 h内接受阿替普酶静脉溶栓治疗患者的临床资料。根据是否出现END,分为恶化组和非恶化组,分析血清白蛋白水平与END发生的相关性。结果共纳入148例患者,其中恶化组39例,非恶化组109例。与非恶化组相比,恶化组总蛋白水平、白蛋白水平和淋巴细胞计数较低,且差异有统计学意义(P<0.05)。恶化组的中性粒细胞计数、红细胞分布宽度、国际标准化比值、纤维蛋白(原)降解产物以及入院时美国国立卫生研究院卒中量表(NIHSS)评分高于非恶化组,差异有统计学意义(P<0.05)。恶化组多伴有心房颤动,且两组在血管狭窄程度及梗死部位方面比较差异也有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清白蛋白(OR=0.873,95%CI 0.768~0.993)、入院时NIHSS评分(OR=1.120,95%CI 1.008~1.245)、中性粒细胞计数(OR=1.271,95%CI 1.048~1.542),以及心源性卒中和责任血管狭窄程度均可能影响急性脑梗死静脉溶栓的短期预后。出院时改良Rankin量表(mRS)评分(平均14 d)与白蛋白水平呈显著负相关(r=-0.205,P=0.013)。结论相比于非恶化患者,恶化患者的白蛋白水平较低。高水平的血清白蛋白是急性缺血性脑卒中静脉溶栓后END的保护因素。血清白蛋白水平与患者的短期预后存在相关性,白蛋白水平越低,mRS评分越高,预后越差。 | 钱新宇 吕金峰 Bilal Muhammad 杜波 耿德勤 | 2019 | 中国医师进修杂志2019，42，4： | 33 |
| 2 | Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma显示文摘Tumor cells induce an immunosuppressive microen-vironment which leads towards tumor immune escape. Understanding the intricacy of immunomodulation by tumor cells is essential for immunotherapy. Indoleamine 2,3-dioxygenase(IDO) is an immunosuppressive enzyme which mediates tumor immune escape in various cancers including hepatocellular carcinoma(HCC). IDO up-regulation in HCC may lead to recruitment of regulatory T-cells into tumor microenvironment and therefore inhibit local immune responses and promote metastasis. HCC associated fibroblasts stimulate natural killer cells dysfunction through prostaglandin E2 and subsequently IDO promotes favorable condition for tumor metastasis. IDO up-regulation induces immuno-suppression and may enhance the risk of hepatitis C virus and hepatitis B virus induced HCC. Therefore, IDO inhibitors as adjuvant therapeutic agents may have clinical implications in HCC. This review proposes future prospects of IDO not only as a therapeutic target but also as a prognostic marker for HCC. | Kashif Asghar Asim Farooq Bilal Zulfiqar Muhammad Usman Rashid | 2017 | World Journal of Gastroenterology2017，23，13： | 16 |
| 3 | Micro RNAs in colorectal cancer:Role in metastasis and clinical perspectives显示文摘Colorectal cancer(CRC)is the third most common malignancy and the third leading cause of cancer related deaths in the United States.Almost 90%of the patients diagnosed with CRC die due to metastases.Micro RNAs(mi RNAs)are evolutionarily conserved molecules that modulate the expression of their target genes post-transcriptionally,and they may participate in various physiological and pathological processes including CRC metastasis by influencing various factors in the human body.Recently,the role mi RNAs play throughout the CRC metastatic cascade has gain attention.Many studies have been published to link them with CRC metastasis.In this review,we will briefly discuss metastatic steps in the light of mi RNAs,along with their target genes.We will discuss how the aberration in the expression of mi RNAs leads to the formation of CRC by effecting the regulation of their target genes.As mi RNAs are being exploited for diagnosis,prognosis,and monitoring of cancer and other diseases,their high tissue specificity and critical role in oncogenesis make them new biomarkers for the diagnosis and classification of cancer as well as for predicting patients’outcome.Mi RNA signatures have been identified for many human tumors including CRC,and mi RNA-based therapies to treat cancer have been emphasized lately.These will also be discussed in this review. | Shan Muhammad Kavanjit Kaur Rui Huang Qian Zhang Paviter Kaur Hamza Obaid Yazdani Muhammad Umar Bilal Jiang Zheng Liu Zheng Xi-Shan Wang | 2014 | World Journal of Gastroenterology2014，20，45： | 13 |
| 4 | Assessment of sunflower germplasm for phytoremediation of lead-polluted soil and production of seed oil and seed meal for human and animal consumption显示文摘Phytoremediation is a valuable technology for mitigating soil contamination in agricultural lands,but phytoremediation without economic revenue is unfeasible for land owners and farmers.The use of crops with high biomass and bioenergy for phytoremediation is a unique strategy to derive supplementary benefits along with remediation activities.Sunflower(Helianthus annuus L.)is a high-biomass crop that can be used for the phytoremediation of polluted lands with additional advantages(biomass and oil).In this study,40 germplasms of sunflower were screened in field conditions for phytoremediation with the possibility for oil and meal production.The study was carried out to the physiological maturity stage.All studied germplasms mopped up substantial concentrations of Pb,with maximum amounts in shoot>root>seed respectively.The phytoextraction efficiency of the germplasm was assessed in terms of the Transfer factor(TF),Metal removal efficiency(MRE)and Metal extraction ratio(MER).Among all assessed criteria,GP.8585 was found to be most appropriate for restoring moderately Pb-contaminated soil accompanied with providing high biomass and high yield production.The Pb content in the oil of GP.8585 was below the Food safety standard of China,with 59.5% oleic acid and 32.1% linoleic acid.Moreover,amino acid analysis in meal illustrated significant differences among essential and nonessential amino acids.Glutamic acid was found in the highest percentage(22.4%),whereas cysteine in the lowest percentage(1.3%).Therefore,its efficient phytoextraction ability and good quality edible oil and meal production makes GP.8585 the most convenient sunflower germplasm for phytoremediation of moderately Pb-contaminated soil,with fringe benefits to farmers and landowners. | Afsheen Zehra Zulfiqar Ali Sahito Wenbin Tong Lin Tang Yasir Hamid Muhammad Bilal Khan Zarina Ali Beena Naqui Xiaoe Yang | 2020 | Journal of Environmental Sciences2020，32，1： | 10 |
| 5 | Role of flavonoids in plant interactions with the environment and against human pathogens-A review显示文摘Flavonoids are widely-distributed polyphenolic secondary metabolites with diverse biological activities in plants and benefit human health as protective dietary agents.They participate in plants' responses to harsh environmental conditions and effectively regulate the cell differentiation and growth.In plants,the majority of their functions are attributed to their strong antioxidative properties.Similarly,dietary flavonoids protect the human body against free radicals which are associated with the development of cancer and atherosclerosis.Plants rich in polyphenols have been used to cure various diseases because of their antibacterial,antiviral,antifungal and anticancer properties.This review summarizes the up-to-date research trends and development on flavonoids and its derivatives,working mechanisms and potential functions and applications particularly in relation to plant protection and human health.Towards the end,notable concluding remarks with a close-up look at the future research directions have also been presented briefly. | Muhammad Khalid Saeed-ur-Rahman Muhammad Bilal HUANG Dan-feng | 2019 | Journal of Integrative Agriculture2019，18，1： | 8 |
| 6 | 溶栓后中性粒细胞升高与缺血性脑卒中早期神经功能恶化相关性研究显示文摘目的探讨溶栓后中性粒细胞升高与缺血性脑卒中早期神经功能恶化(early neurological deterioration,END)发生的相关性。方法收集2017年1月-2018年11月的发病4.5 h内接受阿替普酶静脉溶栓治疗患者的临床资料。根据是否出现END,分为END组和非END组,观察两组患者溶栓前后中性粒细胞、淋巴细胞等指标的变化,以探讨基线及溶栓后中性粒细胞、淋巴细胞和中性粒细胞/淋巴细胞比率与END的相关性。结果共纳入患者187例,其中END组48例,非END组139例。溶栓前,两组患者除总蛋白(t=2.130,P=0.035)、白蛋白(t=2.777,P=0.007)外,其余指标比较差异均无统计学意义(P>0.05)。溶栓后,白细胞计数、中性粒细胞计数、中性粒细胞/淋巴细胞比值、纤维蛋白酶降解产物、基线和变化美国国立卫生研究院卒中量表评分、心源性脑卒中、责任血管狭窄程度及前循环皮质梗死部位,END组均高于非END组(P<0.05);而总蛋白、白蛋白、淋巴细胞计数、前白蛋白END组低于非END组(P<0.05)。溶栓前后,END组中性粒细胞增加明显(Z=-2.314,P=0.021)。中性粒细胞计数[比值比=1.288,95%置信区间(1.069,1.552)]为静脉溶栓END的独立影响因素之一;且预测END的特异度最高(灵敏度为62.5%,特异度为71.9%)。结论溶栓后中性粒细胞升高与END的发生有一定相关性。动态监测静脉溶栓治疗后的中性粒细胞可有助于预测END的发生。 | 钱新宇 杨思远 Bilal Muhammad 杜波 耿德勤 | 2019 | 华西医学2019，34，6： | 7 |
| 7 | 荧光介孔二氧化硅负载丙硫菌唑纳米颗粒的制备及性能研究显示文摘近年来,丙硫菌唑作为一种新颖的广谱杀菌剂备受关注,但由于其代谢产物对操作人员存在健康风险,导致其在中国的使用和登记受到限制。将丙硫菌唑制备为具有缓慢释放、可提高农药稳定性等特点的缓释制剂可有效改善其带来的健康风险问题。本研究采用纳米荧光介孔二氧化硅制备了丙硫菌唑缓释纳米颗粒,通过扫描电镜(SEM)、透射电镜(TEM)、傅里叶变换红外光谱(FTIR)、X-射线光电子能谱(XPS)、Brunauer-Emmett-Teller(BET)比表面积分析、热重分析(TGA)、荧光光谱以及高效液相色谱仪等手段对其结构与特性进行表征。采用透析袋法探讨了丙硫菌唑在释放介质中的释放行为;利用菌丝生长速率法测定了该载药颗粒对小麦赤霉病原菌的杀菌活性;通过激光共聚焦研究了荧光二氧化硅在小麦赤霉病菌菌丝体以及小麦中的传输情况。结果表明:所制备的载药纳米颗粒外观形貌较为规整,平均粒径为139 nm,其最大载药量可达27.14%;该纳米载药颗粒具有缓释性能,释放曲线符合Ritger-Peppas方程;载药颗粒与丙硫菌唑原药相比具有相同的毒力效果。此外,激光共聚焦结果表明,该荧光二氧化硅纳米颗粒可以在菌丝体以及小麦植株根部吸收和传导。 | 许春丽 Muhammad BILAL 徐博 冉刚超 赵鹏跃 曹冲 李凤敏 曹立冬 黄啟良 | 2020 | 农药学学报2020，22，2： | 6 |
| 8 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 9 | 集成多源遥感数据的PM_(2.5)浓度空间分布制图显示文摘针对传统地面稀疏站点监测PM_(2.5)浓度以点带面的缺陷,本研究拟借助多源遥感数据开展了地面大气细颗粒物PM_(2.5)浓度空间分布模拟研究。以京津冀地区2013年的年均、季均PM_(2.5)浓度模拟图为例,用简化的气溶胶反演算法(SARA)反演了1 km高分辨率AOD,并结合高分辨率遥感提取污染相关地理要素,对研究区PM_(2.5)浓度空间分布进行地理统计模拟及优选。结果表明:1 SARA算法反演的AOD与地基AERONET相关性达0.99,能准确地反映研究区AOD的时空分布特征;2集成多源遥感数据的地理加权回归模型拟合度高(平均R2-0.66),其空间模拟显示研究区平均PM_(2.5)污染南部城镇最重,中东部城区次之,西北山区较轻;3研究区PM_(2.5)污染程度高,全年平均模拟浓度高达75μg/m3,在气候环境及主要污染源季节性差异驱动下,浓度分布季节性特征显著,冬季污染最严重,而夏、秋季相对较轻。该成果对于精细把握PM_(2.5)污染特征,指导污染防控具有重要意义。 | 蒲强 邹滨 翟亮 郭宇 桑会勇 Bilal Muhammad | 2016 | 地球信息科学学报2016，18，12： | 5 |
| 10 | Characterization and physicochemical aspects of novel cellulose-based layered double hydroxide nanocomposite for removal of antimony and fluoride from aqueous solution显示文摘A series of novel adsorbents composed of cellulose(CL)with Ca/Al layered double hydroxide(CC_(x)A;where x represent the Ca/Al molar ratio)were prepared for the adsorption of antimony(Sb(V))and fluoride(F^(-))ions from aqueous solutions.The CC_(x)A was characterized by Fourier-transform infrared spectroscopy(FTIR),Brunauer–Emmett–Teller(BET),elemental analysis(CHNS/O),thermogravimetric analysis(TGA-DTA),zeta potential,X-ray photoelectron spectroscopy(XPS)and scanning electron microscopy with energy dispersive Xray spectroscopy(SEM-EDX)analysis.The effects of varying parameters such as dose,pH,contact time,temperature and initial concentration on the adsorption process were investigated.According to the obtained results,the adsorption processes were described by a pseudo-second-order kinetic model.Langmuir adsorption isotherm model provided the best fit for the experimental data and was used to describe isotherm constants.The maximum adsorption capacity was found to be 77.2 and 63.1 mg/g for Sb(V)and F^(-),respectively by CC_(3)A(experimental conditions:pH 5.5,time 60 min,dose 15 mg/10 mL,temperature 298 K).The CC_(3)A nanocomposite was able to reduce the Sb(V)and F^(-)ions concentration in synthetic solution to lower than 6μg/L and 1.5 mg/L,respectively,which are maximum contaminant levels of these elements in drinking water according to WHO guidelines. | Hanen Bessaies Sidra Iftekhar Muhammad Bilal Asif Jamel Kheriji Chaker Necibi Mika Sillanpää Bechir Hamrouni | 2021 | Journal of Environmental Sciences2021，33，4： | 4 |
| 11 | 从野生与突变株云芝IBL-04提纯锰过氧化物酶及其表征(英文)显示文摘由野生及突变株云芝IBL-04制得细胞外锰过氧化物酶(MnPs),并经过硫酸铵沉淀、透析、离子交换和凝胶渗透层析法等步骤提纯.纯化的酶在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)上于43 kDa区域呈现单一谱带,它适宜的pH值和温度分别为5.0和40°C.突变株MnPs表现出比野生株MnPs更宽的活性pH值范围和更高的热稳定性.从所选突变株所得纯化的MnPs表现出与野生株MnP几乎相同的电泳性质、稳态动力学、金属离子和EDCs降解效率.该生物酶与Mn^(2+)一起催化的反应速率最快,但最高的亲和性对应于ABTS、甲氧基羟苯基乙二醇、4-氨基苯酚和活性染料.Mn^(2+)和Cu^(2+)可显著提高MnPs的活性,但Zn^(2+),Fe^(2+),EDTA和半胱氨酸则会不同程度地抑制其活性,Hg^(2+)是最强的活性抑制剂.所有来源的MnPs均可有效催化EDCs、壬基苯酚和二氯苯氧氯酚降解,处理3 h可除去80%以上,在MnPs-介质体系中可进一步提高到90%.综上,云芝MnPs生物酶具有较高的pH适用性和热稳定性、独特的Michaelis-Menten动力学参数和高的EDCs去除效率等特点。 | Muhammad Asgher Muhammad Ramzan Muhammad Bilal | 2016 | Chinese Journal of Catalysis2016，37，4： | 4 |
| 12 | MADCR:Mobility Aware Dynamic Clustering-Based Routing Protocol in Internet of Vehicles显示文摘Internet of Vehicles(IoV)is an evolution of the Internet of Things(IoT)to improve the capabilities of vehicular ad-hoc networks(VANETs)in intelligence transport systems.The network topology in IoV paradigm is highly dynamic.Clustering is one of the promising solutions to maintain the route stability in the dynamic network.However,existing algorithms consume a considerable amount of time in the cluster head(CH)selection process.Thus,this study proposes a mobility aware dynamic clustering-based routing(MADCR)protocol in IoV to maximize the lifespan of networks and reduce the end-to-end delay of vehicles.The MADCR protocol consists of cluster formation and CH selection processes.A cluster is formed on the basis of Euclidean distance.The CH is then chosen using the mayfly optimization algorithm(MOA).The CH subsequently receives vehicle data and forwards such data to the Road Side Unit(RSU).The performance of the MADCR protocol is compared with that ofAnt Colony Optimization(ACO),Comprehensive Learning Particle Swarm Optimization(CLPSO),and Clustering Algorithm for Internet of Vehicles based on Dragonfly Optimizer(CAVDO).The proposed MADCR protocol decreases the end-toend delay by 5–80 ms and increases the packet delivery ratio by 5%–15%. | Sankar Sennan Somula Ramasubbareddy Sathiyabhama Balasubramaniyam Anand Nayyar Chaker Abdelaziz Kerrache Muhammad Bilal | 2021 | China Communications2021，18，7： | 4 |
| 13 | A reliable, delay bounded and less complex communication protocol for multicluster FANETs显示文摘 | Wajiya Zafar Bilal Muhammad Khan | 2017 | Digital Communications and Networks2017，3，1： | 4 |
| 14 | 黄渤海气溶胶光学厚度的多源卫星遥感产品精度分析和时空分布特征研究显示文摘以黄渤海上空大气为目标研究区,基于AERONET观测网,获取该区域2015—2017年的气溶胶光学厚度(AOD)实测数据,并对可见红外成像辐射计VIIRS,中分辨率成像光谱仪MODIS,静止水色卫星成像仪GOCI与新一代地球同步气象卫星AHI H8的AOD遥感产品展开精度验证.同时,利用长时间的遥感影像探究并分析AOD在不同时空尺度下的分布特征与变化情况.结果表明:同其它AOD遥感产品相比,GOCI AOD展示出了高采样频率及高精度的特性.此外,在研究区域AOD的逐小时遥感影像中未发现明显的变化规律,而月平均图则显示出从黄渤海西部至中部再到东部AOD逐渐递减的趋势,且该趋势在研究区域不同的地方是具有差异的.不仅如此,本文还尝试分析影响AOD反演精度的潜在因子,发现其可能与地表反射率提取的准确度与预设气溶胶模型设置的合理性有关. | 毛颖 郑君亮 丘仲锋 Muhammad Bilal | 2021 | 环境科学学报2021，41，7： | 3 |
| 15 | Dengue fever treatment with Carica papaya leaves extracts显示文摘The main objective of the current study is to investigate the potential of Carica papaya leaves extracts against Dengue fever in 45 year old patient bitten by carrier mosquitoes.For the treatment of Dengue fever the extract was prepared in water.25 mL of aqueous extract of C.papaya leaves was administered to patient infected with Dengue fever twice daily i.e.morning and evening for five consecutive days.Before the extract administration the blood samples from patient were analyzed.Platelets count(PLT),White Blood Cells(WBC) and Neutrophils(NEUT) decreased from 176×10~3/μ L,8.10×10~3/μ L,84.0%to 55×10~3/μ L,3.7×10~3/μL and 46.0%.Subsequently,the blood samples were rechecked after the administration of leaves extract.It was observed that the PLT count increased from 55×10~3/μ L to 168×10~3/μ L,WBC from 3.7×10~3/μ L to 7.7×10~3/μ L and NEUT from 46.0%to 78.3%.From the patient feelings and blood reports it showed that Carica papaya leaves aqueous extract exhibited potential activity against Dengue fever.Furthermore,the different parts of this valuable specie can be further used as a strong natural candidate against viral diseases. | Nisar Ahmad Hina Fazal Muhammad Ayaz Bilal Haider Abbasi Ijaz Mohammad Lubna Fazal | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 3 |
| 16 | Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma显示文摘BACKGROUND Numerous studies have demonstrated that human epididymis protein 4(HE4)is overexpressed in various malignant tissues including ovarian,endometrial,lung,breast,pancreatic,and gastric cancers.However,no study has examined the diagnostic impact of HE4 in patient with esophageal squamous cell carcinoma(ESCC)until now.AIM To analyze the value of four serum tumor markers for the diagnosis of ESCC,and examine the associations of serum levels of HE4 with ESCC patients’clinicopathological characteristics.METHODS The case group consisted of 80 ESCC patients,which were compared to a control group of 56 patients with benign esophageal disease.Serum levels of HE4,carcinoma embryonic antigen(CEA),alpha fetal protein,and carbohydrate antigen 19-9(CA19-9)were detected by ELISA.The associations of serum HE4 levels with ESCC patients’clinicopathological characteristics such as gender,tumor location,and pathological stage were also examined after operation.RESULTS The result of ELISA showed that serum HE4 level was significantly higher in the patients with ESCC than in the controls,and the staining intensity was inversely correlated with the pathological T and N stages.Serum HE4 levels had a sensitivity of 66.2%and specificity of 78.6%when the cutoff value was set at 3.9 ng/mL.Moreover,the combined HE4 and CA19-9 increased the sensitivity to 83.33%,and interestingly,the combination of HE4 with CEA led to the most powerful sensitivity of 87.5%.Furthermore,A positive correlation was observed between HE4 serum levels and pathological T and N stages(P=0.0002 and 0.0017,respectively),but there was no correlation between HE4 serum levels and ESCC patient gender(P=0.4395)or tumor location(P=0.6777).CONCLUSION The results of this study suggest that detection of serum HE4 levels may be useful in auxiliary diagnosis and evaluation of the progression of ESCC. | Shi-Yuan Liu Muhammad Ahsan Bilal Jian-Hong Zhu Shao-Min Li | 2020 | World Journal of Gastrointestinal Oncology2020，12，10： | 3 |
| 17 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 18 | MHD Maxwell Fluid with Heat Transfer Analysis under Ramp Velocity and Ramp Temperature Subject to Non-Integer Differentiable Operators显示文摘The main focus of this study is to investigate the impact of heat generation/absorption with ramp velocity and ramp temperature on magnetohydrodynamic(MHD)time-dependent Maxwell fluid over an unbounded plate embedded in a permeable medium.Non-dimensional parameters along with Laplace transformation and inversion algorithms are used to find the solution of shear stress,energy,and velocity profile.Recently,new fractional differential operators are used to define ramped temperature and ramped velocity.The obtained analytical solutions are plotted for different values of emerging parameters.Fractional time derivatives are used to analyze the impact of fractional parameters(memory effect)on the dynamics of the fluid.While making a comparison,it is observed that the fractional-order model is best to explain the memory effect as compared to classical models.Our results suggest that the velocity profile decrease by increasing the effective Prandtl number.The existence of an effective Prandtl number may reflect the control of the thickness of momentum and enlargement of thermal conductivity.The incremental value of the M is observed for a decrease in the velocity field,which reflects to control resistive force.Further,it is noted that the Atangana-Baleanu derivative in Caputo sense(ABC)is the best to highlight the dynamics of the fluid.The influence of pertinent parameters is analyzed graphically for velocity and energy profile.Expressions for skin friction and Nusselt number are also derived for fractional differential operators. | Thabet Abdeljawad Muhammad Bilal Riaz Syed Tauseef Saeed Nazish Iftikhar | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 2 |
| 19 | An Efficient Internet Traffic Classification System Using Deep Learning for IoT显示文摘Internet of Things(IoT)defines a network of devices connected to the internet and sharing a massive amount of data between each other and a central location.These IoT devices are connected to a network therefore prone to attacks.Various management tasks and network operations such as security,intrusion detection,Quality-of-Service provisioning,performance monitoring,resource provisioning,and traffic engineering require traffic classification.Due to the ineffectiveness of traditional classification schemes,such as port-based and payload-based methods,researchers proposed machine learning-based traffic classification systems based on shallow neural networks.Furthermore,machine learning-based models incline to misclassify internet traffic due to improper feature selection.In this research,an efficient multilayer deep learning based classification system is presented to overcome these challenges that can classify internet traffic.To examine the performance of the proposed technique,Moore-dataset is used for training the classifier.The proposed scheme takes the pre-processed data and extracts the flow features using a deep neural network(DNN).In particular,the maximum entropy classifier is used to classify the internet traffic.The experimental results show that the proposed hybrid deep learning algorithm is effective and achieved high accuracy for internet traffic classification,i.e.,99.23%.Furthermore,the proposed algorithm achieved the highest accuracy compared to the support vector machine(SVM)based classification technique and k-nearest neighbours(KNNs)based classification technique. | Muhammad Basit Umair Zeshan Iqbal Muhammad Bilal Jamel Nebhen Tarik Adnan Almohamad Raja Majid Mehmood | 2022 | Computers, Materials & Continua2022，，4： | 1 |
| 20 | 癫痫的病因诊断——附一例线粒体病基因诊断及分析显示文摘目的:分析线粒体病患者癫痫的特点及治疗。方法:报道1例反复癫痫发作并最终确诊为线粒体病患者的临床资料,结合文献进行回顾性分析。结果:患者青少年期出现癫痫症状,部分性癫痫症状及全面广泛强直性发作均在病程中有所体现,多联抗癫痫药物控制不佳,外周血基因检测示mtDNA A3243G突变(44.7%),诊断线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)明确。入院后予减轻线粒体负担,改善细胞功能及多联抗癫痫治疗后症状好转。结合既往国内外文献,进一步分析线粒体病癫痫的机制,发作形式及治疗原则。结论:癫痫是线粒体疾病常见的临床症状之一,需采取综合治疗。 | 陈松洁 牟英峰 范佑民 Bilal Muhammad 耿德勤 | 2018 | 神经损伤与功能重建2018，13，10： | 1 |
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