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| 1 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 2 | Abu Dhabi Sabkha,Persian Gulf,revisited:Application of strontium isotopes to test an early dolomitization model显示文摘 | DANIEL W MULLER JUDITH A MCKENZIE PAUL A MUELLER | 1990 | Geology1990，18，7： | 1 |
| 3 | Determinants of agricultural land abandonment in Post-soviet European Russia显示文摘 | Prishchepov Alexander V Mueller Daniel | 2013 | Land Use Policy2013，30，1： | 1 |
| 4 | High resolution real-time sonography of the thyroid显示文摘 | Simeone JF Daniels GH Mueller PR | 1982 | Radiology1982，145，2： | 1 |
| 5 | Phosphorus losses as affected by tillage and manure application显示文摘 | Mueller D H Wendt R C Daniel T C | 1984 | Soil Science Society of America Journal1984，48，： | 1 |
| 6 | Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax显示文摘 | Martin Czerny Andreas Salat Tatjana Fleck Wolfgang Hofmann Daniel Zimpfer Franz Eckersberger Walter Klepetko Ernst Wolner Michael-Rolf Mueller | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 7 | Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase显示文摘 | Ulf Landmesser Niels Engberding Ferdinand H. Bahlmann Arnd Schaefer Antje Wiencke Andre Heineke Stephan Spiekermann Denise Hilfiker-Kleiner Christian Templin Daniel Kotlarz Maja Mueller Martin Fuchs Burkhard Hornig Hermann Haller Helmut Drexler | 2004 | Circulation2004，，14： | 1 |
| 8 | High-resolution real-time sonography of the thyroid显示文摘 | Simeone JF Daniels GH Mueller PR | | 0，，02： | 1 |
| 9 | mTOR at the crossroads of T cell proliferation and tolerance显示文摘 | Anna Mondino Daniel L. Mueller | 2007 | Seminars in Immunology2007，，3： | 1 |
| 10 | Phosphorus losses in runoff as affected by tillage显示文摘 | Andraski B J Mueller D H Daniel T C | 1985 | Soll Sci Soc A m J1985，49，： | 1 |
| 11 | High-resolution real-time sonography of the thyroid 显示文摘 | Simeone JF Daniels GH Mueller PR | 1982 | Radiology1982，145，2： | 1 |
| 12 | Abu Dhabi sabkha, Persian Gulf, Revisited : Application of strontium isotopes to test an early dolomitization model显示文摘 | Daniel W Muller J udit h A Mckenzie Paul A Mueller | 1990 | Geology1990，18，： | 1 |
| 13 | Phosphorus losses in runoff as affected by tillage显示文摘 | Andraski B J Mueller D H Daniel T C | 1985 | Soil Sci Soc Am J1985，49，： | 1 |
| 14 | Radiofrequency tissue ablation: Importance of local temperature along the electrode tip exposure in determining lesion shape and size显示文摘 | S. Nahum Goldberg G. Scott Gazelle Elkan F. Halpern William J. Rittman Peter R. Mueller Daniel I. Rosenthal | 1996 | Academic Radiology1996，，3： | 1 |
| 15 | Targeted Gene Knockouts Reveal Overlapping Functions of the Five Physcomitrella patens FtsZ Isoforms in Chloroplast Division, Chloroplast Shaping, Cell Patterning, Plant Development, and Gravity Sensing显示文摘叶绿体和细菌的房间由二进制分裂划分。在这个收缩部门的关键蛋白质是 FtsZ,类似于真核细胞的导管素的自我装配的 GTPase。在初核质, FtsZ 被单个基因几乎总是编码,而植物怀有几个原子编码 FtsZ 相当或相同的事物。在种子植物,在二个家庭和所有的这些蛋白质组只被进口进质体。相反,基础陆地植物 Physcomitrella 圣餐盘,苔藓,与一个成员一起编码第三个 FtsZ 家庭。这蛋白质双地被指向到质体并且到 cytosol。这里,我们在 P 在所有 ftsZ 基因的指向的基因混乱上报导。圣餐盘。单个、双的猛烈异种的随后的分析不仅在质体分割,而且在叶绿体塑造,房间 patterning,植物发展,并且严肃察觉到揭示了不同 FtsZ isoforms 的一个复杂相互作用。这些结果支持 plastoskeleton 和它的功能的集成的概念进细胞骨架,至少在苔藓 P。圣餐盘。 | Anja Martin Daniel Lang Sebastian T. Hanke Stefanie J.X. Mueller Eric Sarnighausen Marco Vervliet-Scheebaum Ralf Reski | 2009 | Molecular Plant2009，2，6： | 1 |
| 16 | Characteriza- tion of periodic micro -/nano - patterns for wear mini- mization of electrical eontacts显示文摘 | Daniel C Mucklich F Mueller J | 2003 | Praktische Metallog- raphie2003，40，8： | 1 |
| 17 | Tillage and canopy cover effects on interrill erosion from first-year alfalfa显示文摘 | Sturgul S J Daniel T C Mueller D H | 1990 | Soil Science Sociaty of Ameirican Journal1990，54，6： | 1 |
| 18 | Phosphorus losses in runoff as affected by tillage显示文摘 | ANDRASKI B J MUELLER D H DANIEL T C | 1985 | Soil Soc Sci Am J1985，49，： | 1 |
| 19 | Operational continental-scale land cover mapping of Australia using the Open Data Cube显示文摘To comprehensively support national and international initiatives for sustainable development,land cover products need to be reliably and routinely generated within operational frameworks.Coupled with consistent semantics and taxonomies,ensuring confidence in mapping land cover for multiple time periods,facilitates informed decision-making at scales appropriate to multiple policy domains.The United Nations Food and Agriculture Organisation(FAO)Land Cover Classification System(LCCS)provides a taxonomy that comparable at different scales,level of detail and geographic location.The Open Data Cube(ODC)initiative offers a framework for operational continental-scale land cover mapping using analysis-ready Earth Observation data.This study utilised the FAO LCCS framework and the Landsat sensor data through Digital Earth Australia(DEA;Australia’s ODC instance)to generate consistent and continent-wide land cover mapping(DEA Land Cover)of the Australian continent.DEA Land Cover provides annual maps from 1988 to 2020 at 25 m resolution.Output maps were validated with∼12,000 independent validation points,giving an overall map accuracy of 80%.DEA Land Cover provides Australia with a nationally consistent picture of land cover,with an open-source software package using readily available global coverage data and demonstrates a pathway of adoption for national implementations across the world. | Christopher J.Owers Richard M.Lucas Daniel Clewley Belle Tissott Sean M.T.Chua Gabrielle Hunt Norman Mueller Carole Planque Suvarna M.Punalekar Pete Bunting Peter Tan Graciela Metternicht | 2022 | International Journal of Digital Earth2022，15，1： | 1 |
| 20 | Soil and water losses as affected by tillage and manure application显示文摘 | Mueller DH Wendt RC Daniel TC | 1984 | Soil Science Society of America Journal f1984，48，4： | 1 |
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