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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients显示文摘AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact test.RESULTS: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV. | Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 3 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 4 | Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population显示文摘 | Andrés López-Cortés Gabriela Jaramillo-Koupermann María J. Mu?oz Alejandro Cabrera Carolina Echeverría Felipe Rosales Nicolás Vivar César Paz-y-Mi?o | 2013 | The American Journal of the Medical Sciences2013，，： | 1 |
| 5 | Role of angiotensin II in liver fibrosis‐induced portal hypertension and therapeutic implications显示文摘 | Alejandro Lugo‐Baruqui José Francisco Mu?oz‐Valle Sigifredo Arévalo‐Gallegos Juan Armendáriz‐Borunda | 2010 | Hepatology Research2010，，1： | 1 |
| 6 | Long-term comparison of corneal aberration changes after laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser flap creation显示文摘 | Gonzalo Mu?oz César Albarrán-Diego Teresa Ferrer-Blasco Santiago García-Lázaro Alejandro Cervi?o-Expósito | 2010 | Journal of Cataract & Refractive Surgery2010，，11： | 1 |
| 7 | Guild structure of carnivorous intertidal fishes of the Chilean coast: implications of ontogenetic dietary shifts显示文摘 | Alejandro A. Mu?oz F. Patricio Ojeda | 1998 | Oecologia1998，，4： | 1 |
| 8 | T2relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content显示文摘 | Marinelli NL Haughton VM Mu oz Alejandro | 2009 | Spine2009，34，5： | 1 |
| 9 | Genetic Polymorphisms in Apolipoprotein E and Glutathione Peroxidase 1 Genes in the Ecuadorian Population Affected With Alzheimer?s Disease显示文摘 | César Paz-y-Mi?o Caty Carrera Andrés López-Cortés María José Mu?oz Nadia Cumbal Bernardo Castro Alejandro Cabrera María Eugenia Sánchez | 2010 | The American Journal of the Medical Sciences2010，，5： | 1 |
| 10 | Guild structure of carnivorous intertidal fishes of the Chilean coast: implications of ontogenetic dietary shifts显示文摘 | Alejandro A. Mu?oz F. Patricio Ojeda | 1998 | Oecologia1998，，4： | 1 |
| 11 | 经纬线上的7色光显示文摘最能吸引儿童的是跳跃的色彩,建筑师Alejandro Munoz Miranda自然是深知这一点的,或许当他接受市政府委托的这个项目的时候,他就已经在思考,如何为那些初闯人世的孩子们展现周遭世界的美。 | 赵博 Alejandro Muoz Miranda | 2011 | 建筑知识2011，31，2： | 0 |
| 12 | 墨西哥湖屋显示文摘Casa del Lago是一栋毗邻水域的独立住宅。住户为一对拥有多元文化的成熟夫妇。设计师利用建筑场域的特点,将开放的公共空间也规划成为日常使用动线的一部分,并将墨西哥尤卡坦文化融入空间之中,同时让房屋还可以容纳主人的艺术收藏品。 | Carlos Patrón Carlos Patrón lbarra Alejandro Patrón Sansor Ana Pat ró n Ibarra Estefanía Rivero Janssen Joaquín Mu?oz Olivera Leo Espinosa 李薇 | 2019 | 现代装饰2019，0，11： | 0 |
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