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    题名 作者 年代 出处 被引量
1胶质瘤的基因治疗(英文)显示文摘Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy.Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths.To date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials.The most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal models.In this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM.Tobias A Ahmed A Moon KS Lesniak MS. 2013中华神经外科疾病研究杂志2013,12,4:16
2异麦芽酮糖醇的性质和用途显示文摘Palatinit公司生产的异麦芽酮糖醇是一种糖的替代物.它由双糖醇(多元醇)组成,而不是一种高度甜味剂.源于糖的异麦芽酮糖醇的味道像糖一样自然,展现了一种纯自然的甜味.异麦芽酮糖醇的感官特性,生理学性质及物理化学性质使得糖果、烘烤制品、医药和其他应用领域方面都大获裨益。Ms. Anette. Radowski MS. Ann Ang 2000中国食品添加剂2000,11,2:13
3Health and safety hazards associated with subways: A review显示文摘Dr. R. R. M. Gershon DrPH. Dr. K. A. Qureshi Ms. M. A. Barrera Ms. M. J. Erwin Dr. F. Goldsmith 2005Journal of Urban Health2005,,1:1
4Sorting out the connections between the built environment and health: A conceptual framework for navigating pathways and planning healthy cities显示文摘Dr. Mary E. Northridge Dr. Elliot D. Sclar Ms. Padmini Biswas 2003Journal of Urban Health2003,,4:1
5Characteristics and circumstances of falls in a hospital setting显示文摘Eileen B. Hitcho MS Ms. Melissa J. Krauss MPH Stanley Birge MD William Claiborne Dunagan MD Irene Fischer MPH Shirley Johnson RN MS MBA Patricia A. Nast RN Eileen Costantinou MSN RN Dr. Victoria J. Fraser MD 2004Journal of General Internal Medicine2004,,7:1
6Recovery of bulk DNA from soil by a rapid, small-scale extraction method显示文摘Ms. L. Arlene Porteous John L. Armstrong 1991Current Microbiology1991,,6:1
7Characteristics and circumstances of falls in a hospital setting显示文摘Eileen B. Hitcho MS Ms. Melissa J. Krauss MPH Stanley Birge MD William Claiborne Dunagan MD Irene Fischer MPH Shirley Johnson RN MS MBA Patricia A. Nast RN Eileen Costantinou MSN RN Dr. Victoria J. Fraser MD 2004Journal of General Internal Medicine2004,,7:1
8Sorting out the connections between the built environment and health: A conceptual framework for navigating pathways and planning healthy cities显示文摘Dr. Mary E. Northridge Dr. Elliot D. Sclar Ms. Padmini Biswas 2003Journal of Urban Health2003,,4:1
9CRIA Organized a Field Trip to Europe显示文摘Upon the invitation of ASSOCOMAPLAST, the Italian Plastics and Rubber Processing Machinery and Moulds Manufacturers' Association, from November 23 to December 2, 2011, CRIA organized 35 domestic enterprise representatives to visit COMERIO, an Italian rubber machinery and equipment manufacturer,Ms. Xu Wenying DSG of CRIA 2012中国橡胶2012,28,4:0
10红包的学问你一辈子参不透显示文摘以前从没觉得春节发红包是个难题。从去年开始,春节曾经的和谐被打破。或许,那个打破和谐的音符是我把女儿霖霖送到了英国读书。虽然我手头略有些吃紧,不过,给孩子们准备的红包是一分钱也没少。大年初二,我和老公共有的朋友圈里有人提议聚餐,我们俩揣着厚厚一叠红包兴;中;中去赴会,没想到红包还没出手,先遭遇了尴尬。朋友们七嘴八舌调侃:“还是你们强,英国的学费不便宜啊。”“那是,你也不看看,阿梅是公务员,老刘是国企高管,就这一个宝贝女儿,有钱不给她花给谁花?!”MS.梅 2014花样盛年2014,,2:0
11耐力的极限挑战显示文摘垂直马拉松通俗一点解释就是爬楼梯,而爬楼梯这项运动于20世纪70年代首次被称为“垂直竞跑”,现在这一运动已经成为横跨美国、加拿大、欧洲以及亚洲的全球性体育竞技比赛,并有专业的运动员每年针对该比赛进行训练,为冲顶一座座世界上的高层建筑物作准备。MS.伍 2014年轻人(B版)(魅力校园)2014,,3:0
12生命中的奇妙缘分 囧囧与熊熊的相依相伴显示文摘虽然捡屎官的日子并不轻松,但两个小家伙能健康、幸福地让她给它们养老送终,就是她最大的幸福。愿所有喜欢养宠物的人,都能对你带回去的那个小家伙不离不弃,直到生命的尽头。因为你的生活多姿多彩,而它们的生活却只有你。Q&A问答时间《狗迷》:为什么会有养狗的想法?Ms.黄:很多人会因为一本书或一部电影爱上一个犬种,我也不例外。Ms.黄 2016宠物世界2016,0,4:0
13Textile Industry-Strategic Pillar Industry in Building a Moderately Prosperous Society in All Respects显示文摘在 ITMF2011 世界纺织品顶点,它在 9 月 21,2011 日被保持期间,杜玉洲先生,作为主调说话者,中国纺织品衣服委员会的 Presiden 在中国纺织品工业上介绍了一篇讲话。Ms. Gao(Translated) 2011China Textile2011,,10:0
1432岁那年我才发现,我的孩子不是我的孩子显示文摘一32岁那年,我迎来了与我分享心跳的生死之交。小小的人儿,从只会用哭声表达,到咿呀学语;从整日挂在怀里,到蹒跚走路。整个家庭的照顾者们都偏执地把这个小小的生命定位在只有成年人才知道他的需求,而他是不知道自己要什么的。选玩具时,妈妈两眼放光地选着锻炼大脑和培养专注力的乐高。Ms.洋葱 2020当代教育家2020,,5:0
15武侠类影视作品在泰国显示文摘中国武侠文化在泰国传播历史长久,影响巨大。尤其是自从20世纪50年代末金庸的《射雕英雄传》被译介到泰国后,马上成为最受泰国读者欢迎的小说类型之一。在泰国武侠作品的传播途径,不仅仅限于单行本出版、中泰文报纸连载、或漫画等这些纸面出版物,而武侠影视作品更是影响最大,且是不可缺少的要素途径之一。Ms. Wimonrat Wasinnitiwong(刘凤美) 2010电影文学2010,,15:0
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