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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Cellulose biosynthesis and function in bacteria显示文摘 | Peter R RaphaeJ M Moshe B | 1991 | Micro1991，55，1： | 1 |
| 3 | Modification of carbohydrate content in developing tomato fruit显示文摘 | Ilan L Moshe B Michael F | 1999 | Hortscience1999，34，6： | 1 |
| 4 | A comparative study of the glucose,white blood cell count,interleukin-6,and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes 显示文摘 | Roberto R Yoon B H Moshe M el al | 1993 | Am J Obstet Gynecol1993，169，： | 1 |
| 5 | A Digital Gigapixel Large-format Tile-scan Camera显示文摘 | MOSHE B | 2011 | IEEE Computer Graphics and Application2011，31，1： | 1 |
| 6 | Cellulose biosynthesis and function in bacteria显示文摘 | Peter R Raphael M Moshe B | 1991 | Microbiological Reviews1991，55，1： | 1 |
| 7 | Cloning of a novel cytochrome P450(CYP4CI5) differentially expressed in the steroidogenic glands of an arthropod显示文摘 | Chantal D V Detlef B Moshe T | 1999 | Biochemical and Biophysical Research Communications1999，264，： | 1 |
| 8 | Kinetics and mechanisms of metal hydrides formation--A review显示文摘 | JOSEPH B MOSHE H M | 1997 | Journal of Alloys and Compounds1997，，： | 1 |
| 9 | Nnmerical simulation of the airflow across trees in a windbreak显示文摘 | Moshe R Gil M Arieh B | | 0，，01： | 1 |
| 10 | Desalination and Reuse of High-Salinity Shale Gas Produced Water: Drivers, Technologies, and Future Directions 显示文摘 | Shaffer D L Chavez L H A Moshe B S | 2013 | Envi- ronmental Science & Technology2013，47，17： | 1 |
| 11 | Efficacy of topical application of eosin for ulcerated hemangiomas 显示文摘 | Moshe L Dan B Sulochana B | 2009 | Journal of the American Academy of Dermatolog2009，60，2： | 1 |
| 12 | The a-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library显示文摘 | Moshe B Ephraim K Sara | 1997 | Proc Haft Acad Sci USA1997，94，： | 1 |
| 13 | Discrete Choice Methods and their Applications to Short Term Travel Decisions 显示文摘 | Moshe B A Michel B | 1999 | International Series in Operations Research & Management Science1999，23，： | 1 |
| 14 | Singularity analysis of a class of parallel robots based on Grassmann-Cayley algebra显示文摘 | PATRICIA B MOSHE S | 2006 | Mechanism and Machine Theory2006，41，6： | 1 |
| 15 | Stress localization and strength optimization of frame material with periodic microstructure显示文摘 | Fabian Lipperman Moshe B Fuchs Michael Ryvkin | | 0，，45： | 1 |
| 16 | Arthropod pest resurgence:an overview of potential mechanisms显示文摘 | MARK R.H BETTY B MOSHE C | | 0，，1： | 1 |
| 17 | Microemulsions based on anionic Gemini surfactant显示文摘 | MAGDASSI S MOSHE M B TALMON Y | 2003 | Colloids and Surfaces A2003，212，1： | 1 |
| 18 | Cellulose biosynthesis and function in bacteria显示文摘 | Peter R Raphael M Moshe B | 1991 | Microbiological Reviews1991，55，1： | 1 |
| 19 | Can You tube it? Providing chemistry teachers with technological tools and enhancing their self-efficacy beliefs显示文摘 | Ron B Moshe J Ziva B D | 2013 | Chemistry Edu- cation Research and Practice2013，14，： | 1 |
| 20 | Thermal effects on the accuracy of numerically controlled machine tools显示文摘 | RAGHUNATH V MOSHE B SHAW M C | 1986 | CIRPAnnals-Manufacturing Technology1986，，： | 1 |
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