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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Relationship between Oral Glucose Tolerance Test Characteristics and Adverse Pregnancy Outcomes among Women with Gestational Diabetes Mellitus显示文摘 | Hui Feng Wei-Wei Zhu Hui-Xia Yang Yu-Mei Wei Chen Wang Ri-Na Su Moshe Hod Eran Hadar | 2017 | Chinese Medical Journal2017，，9： | 26 |
| 3 | Recent progress and challenges in screening and characterization of UGT1A1 inhibitors显示文摘Uridine-diphosphate glucuronosyltransferase 1 A1(UGT1 A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1 A1 may trigger adverse drug/herb–drug interactions, or result in metabolic disorders of endobiotic metabolism. Therefore, both the US Food and Drug Administration(FDA)and the European Medicines Agency(EMA) have recommended assaying the inhibitory potential of drugs under development on the human UGT1 A1 prior to approval. This review focuses on the significance,progress and challenges in discovery and characterization of UGT1 A1 inhibitors. Recent advances in the development of UGT1 A1 probes and their application for screening UGT1 A1 inhibitors are summarized and discussed in this review for the first time. Furthermore, a long list of UGT1 A1 inhibitors, including information on their inhibition potency, inhibition mode, and affinity, has been prepared and analyzed. Challenges and future directions in this field are highlighted in the final section. The information and knowledge that are presented in this review provide guidance for rational use of drugs/herbs in order to avoid the occurrence of adverse effects via UGT1 A1 inhibition, as well as presenting methods for rapid screening and characterization of UGT1 A1 inhibitors and for facilitating investigations on UGT1 A1–ligand interactions. | Xia Lv Yangliu Xia Moshe Finel Jingjing Wu Guangbo Ge Ling Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 14 |
| 4 | Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models显示文摘 | Shao-wen TIAN Moshe LAUDON Li HAN Jun GAO Fu-lian HUANG Yu-feng YANG Hai-feng DENG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 11 |
| 5 | 整体移动和倾斜移动技术内收尖牙治疗时间及支抗控制的比较研究显示文摘 | Nir Shpack Moshe Davidovitch Ofer Sarne Narchos Panayi Alexander D.Vardimon 王瑞端 | 2008 | 中国实用口腔科杂志2008，1，1： | 10 |
| 6 | FTO: linking m^6A demethylation to adipogenesis显示文摘 | Moshe Shay Ben-Haim Sharon Moshitch-Moshkovitz Gideon Rechavi | 2015 | Cell Research2015，25，1： | 8 |
| 7 | Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification显示文摘AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. | Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 8 | Neu-P11通过抑制氧化应激降低急性高眼压大鼠眼内压显示文摘目的褪黑素(melatonin,Mel)是由松果体分泌的一类吲哚类神经内分泌激素,具有调节昼夜节律和抗氧化等广泛的生物学作用。新型褪黑素非选择性受体激动剂NeuP11与褪黑素作用相似。该文旨在研究Neu-P11对急性高眼压大鼠眼内压的影响及其相关机制。方法采用Trendelenburg卧位(头低脚高80°位置)法将30只健康8周龄SD大鼠建立急性高眼压模型,即动物被置于Trendelenburg卧位,用Tonopen XL接触眼压计每5 min测量1次眼内压,取20 min最大值。建模后将大鼠随机分为5组:正常眼压+生理盐水组、高眼压+生理盐水组、高眼压+10 mg·kg^(-1)Mel组、高眼压+20 mg·kg^(-1)Neu-P11组、高眼压+50 mg·kg^(-1)Neu-P11组,每组6只。给药后平位休息2 h,再次置于Trendelenburg卧位45 min后,连续监测6 h眼内压(每小时1次)。连续给药1周后,注射过量戊巴比妥钠处死SD大鼠,心脏取血,检测急性高眼压大鼠血清中MDA、SOD和GSH-Px的活性;留取各组大鼠眼球进行常规组织学切片,观察SD大鼠视网膜形态学变化。结果 Trendelenburg卧位诱导模型组大鼠眼内压值比正常组升高了约202.9%(P<0.01),且视网膜增厚,层次不清,机体氧化应激水平明显升高。而经Neu-P11和褪黑素治疗后,明显改善了机体氧化应激水平和视网膜水肿,降低大鼠眼内压。结论 Neu-P11可能通过抑制机体氧化应激水平,降低急性高眼压大鼠眼内压。 | 石金凤 张星慧 李美香 佘美华 贺鹏程 田期先 Moshe Laudon 尹卫东 张瑶 | 2017 | 中国药理学通报2017，33，5： | 7 |
| 9 | Genome evolution in allopolyploid wheat—a revolutionary reprogramming followed by gradual changes显示文摘Allopolyploidy accelerates genome evolution in wheat in two ways: 1) allopolyploidization triggers rapid genome alterations (revolutionary changes) through the instantaneous generation of a variety of cardinal genetic and epigenetic changes, and 2) the allopolyploid condition facilitates sporadic genomic changes during the life of the species (evolutionary changes) that are not attainable at the diploid level. The revolutionary alterations, occurring during the formation of the allopolyploid and leading to rapid cytological and genetic diploidization, facilitate the successful establishment of the newly formed allopolyploid in nature. On the other hand, the evolutionary changes, occurring during the life of the allopolyploids, increase the intra-specific genetic diversity, and consequently, increased fitness, adaptability and competitiveness. These phenomena, emphasizing the dynamic plasticity of the allopolyploid wheat genome with regards to both structure and function, are described and discussed in this review. | Moshe Feldman Avraham A. Levy | 2009 | Journal of Genetics and Genomics2009，36，9： | 7 |
| 10 | 新型褪黑素受体激动剂Neu-P11改善慢性睡眠限制大鼠胰岛素敏感性显示文摘目的研究新型褪黑素(melatonin,MLT)受体激动剂Neu-P11对睡眠限制大鼠胰岛素敏感性的影响。方法采用转笼法对SD大鼠进行8 d的睡眠限制,期间每天分别给予腹腔注射Neu-P11(20 mg·kg-1)、MLT(5 mg·kg-1)、生理盐水。监测各组大鼠体重和耗食量,实验末测定空腹血糖、胰岛素、TG、TC、HDL-C水平,进行口服葡萄糖耐量实验(OGTT)。结果睡眠限制后大鼠空腹血糖、血清胰岛素和TG、TC水平明显高于正常对照组,HDL-C水平及葡萄糖耐量降低;而与睡眠限制组比较,Neu-P11或MLT处理组血糖、血清胰岛素、TG、TC水平及HOMA-IR降低、葡萄糖耐量升高。结论 Neu-P11能调节睡眠限制大鼠的糖脂代谢,改善睡眠限制引起的胰岛素抵抗。 | 佘美华 蒋文艳 杨升华 胡小波 Moshe Laudon 尹卫东 | 2013 | 中国药理学通报2013，29，11： | 5 |
| 11 | 脂肪酸通过固醇调节元件结合蛋白1诱导足细胞的损伤显示文摘目的:确定脂代谢和固醇调节元件结合蛋白在糖尿病和肥胖相关肾病和足细胞损伤发病机制中的重要作用,为白桦脂醇治疗糖尿病肾病提供理论依据。方法:游离脂肪酸250μm处理分化后的人足细胞48 h,检测足细胞脂滴形成和TLR2/TLR4mRNA和活化的SREBP1以及TLR4的蛋白表达情况以及炎性细胞因子IL-6的mRNA的表达;SREBP1c脂质体转染足细胞,检测足细胞脂滴形成和TLR4和IL-6的表达。结果:游离脂肪酸250μm作用足细胞24 h即诱导人足细胞凋亡,CARS成像显示足细胞脂滴增加,活化的SREBP1的65 kD部分表达增加,TLR2/TLR4的mRNA和TLR4的蛋白表达增加,IL-6的mRNA增加;SREBP1c转染足细胞后,足细胞内脂质合成明显增加,TLR4的蛋白表达上调,IL-6mRNA表达上调。结论:SREBP1表达上调促进足细胞脂质沉积,诱导TLR2/TLR4通路活化,炎性细胞因子IL-6合成增加。SREBP1在2型糖尿病和肥胖肾病足细胞损伤过程中发挥重要作用,为2型糖尿病肾病和肥胖性肾病提供新的治疗靶点。 | 仇丽茹 唐锦辉 周建华 Moshe Levi | 2013 | 中国医院药学杂志2013，33，18： | 5 |
| 12 | 不同土壤水势下贝莱斯芽孢杆菌B006菌剂对茄子的促生增产作用显示文摘为了明确水肥一体化灌溉系统中不同土壤水势条件下,施用芽孢杆菌B006菌剂对茄子生长及产量的促进作用,采用灌根法测定施用芽孢杆菌B006菌剂(1′107CFU·mL-1)对盆栽茄子幼苗生长的影响。在日光温室开展两因子、两水平交互田间小区试验,在土壤水势分别为-30 kPa和-40 kPa条件下,设置施用和不施用(对照)芽孢杆菌B006菌剂共4组处理。各处理均施用278.77 kg·hm-2化学肥料(N/P/K为17∶9∶34)。采用电子张力计监测土壤水势,采用水肥一体化自动灌溉系统进行灌溉。分别在移栽时和定植后30 d浇灌浓度为1×107CFU·mL-1的B006菌剂稀释液。35 d后测定茄子的株高、茎粗、叶绿素含量和地上部干质量,50 d后调查茄子开花数,每次施肥前测定土壤速效氮、磷、钾含量,收获期测定产量,收获后测定根长和根干质量。结果表明:施用B006菌剂处理的盆栽茄子株高、茎粗、根长和根干质量比对照分别提高了16.7%、20.7%、28.7%和67.0%。在日光温室大棚试验中,施用B006菌剂处理土壤的速效磷、速效钾含量均低于对照;土壤水势-30 kPa和-40 kPa条件下,施用B006菌剂处理的茄子产量比对照分别提高了24.5%和18.1%。当灌溉量从804.88 m3·hm-2减少到574.91 m3·hm-2时,施用B006菌剂的两处理之间产量无显著差异。综上所述,施用芽孢杆菌B006菌剂可以促进茄子对氮、磷、钾的吸收,提高肥料利用率,从而促进植物生长,甚至在少水灌溉条件下不降低茄子产量。 | 耿妍 郭荣君 张爱香 GOVRIN Eri Moshe 李世东 | 2020 | 农业资源与环境学报2020，37，3： | 5 |
| 13 | Expression of Mitochondrial Gene Fragments within the Tapetum Induce Male Sterility by Limiting the Biogenesis of the Respiratory Machinery in Transgenic Tobacco显示文摘Plant mitochondrial genomes (mtDNAs) are large and undergo frequent recombination events. A common phenotype that emerges as a consequence of altered mtDNA structure is cytoplasmic-male sterility (CMS). The molecular basis for CMS remains unclear, but it seems logical that altered respiration activities would result in reduced pollen production. Analysis of tobacco (Nicotiana tabacum) mtDNAs indicated that CMS-associated loci often contain fragments of known organellar genes. These may assemble with organellar complexes and thereby interfere with normal respiratory functions. Here, we analyzed whether the expression of truncated fragments of mitochondrial genes (i.e. atp4, cox1 and rps3) may induce male sterility by limiting the biogenesis of the respiratory machinery. cDNA fragments corresponding to atp4f, cox1f and rps3f were cloned in-frame to a mitochondrial localization signal and a C-termini HA-tag under a tapetum-specific promoter and introduced to tobacco plants by Agrobacterium-mediated transformation. The constructs were then analyzed for their effect on mitochondrial activity and pollen fertility. Atp4f , Cox1f and Rps3f plants demonstrated male sterility phenotypes, which were tightly correlated with the expression of the recombinant fragments in the floral meristem. Fractionation of native organellar extracts showed that the recombinant ATP4f-HA, COX1f-HA and RPS3f-HA proteins are found in large membrane-associated particles. Analysis of the respiratory activities and protein profiles indicated that organellar complex I was altered in Atp4f, Cox1f and Rps3f plants. | Felix Shaya Svetlana Gaiduk Ido Keren Sofia Shevtsov Hanita Zemah Eduard Belausov Dalia Evenor Moshe Reuveni Oren Ostersetzer-Biran | 2012 | Journal of Integrative Plant Biology2012，54，2： | 4 |
| 14 | Neu-p11/Luzindole在胰岛素抵抗脂肪细胞模型中对脂联素/内脏脂肪素的影响显示文摘脂联素(adiponectin)在调节胰岛素敏感性和葡萄糖的内稳态方面发挥着至关重要的作用,与胰岛素抵抗密切相关;内脏脂肪素(visfatin)可与胰岛素受体相互作用,发挥类胰岛素或抗胰岛素样作用,从而降低血糖,其量的变化与胰岛素抵抗的发生也有着紧密的联系。通过'鸡尾酒'法培养并分化3T3-L1前脂肪细胞,油红O染色鉴定脂肪细胞的形态和分化情况,高糖高胰岛素作用于脂肪细胞,建立胰岛素抵抗细胞模型;葡萄糖氧化酶法测定培养基中的糖含量,计算糖消耗量,验证胰岛素抵抗模型的建立。葡萄糖氧化酶法检测药物作用前后培养基中的糖含量,计算糖消耗量;Western-blot检测药物作用前后脂联素和内脏脂肪素表达的变化,来研究Neu-P11改善高糖高胰岛素引起3T3-L1脂肪细胞发生胰岛素抵抗的机制,以及葡萄糖摄取和脂联素及内脏脂肪素的变化;探讨褪黑素受体拮抗剂Luzindole与Neu-P11联合作用后,对葡萄糖摄取及脂联素和内脏脂肪素表达的影响。结果表明,高糖高胰岛素作用于分化成熟的脂肪细胞24 h后,糖消耗量与正常对照组细胞相比明显降低,其胰岛素敏感性也随之下降;胰岛素抵抗组细胞用褪黑素和Neu-P11处理后,糖消耗量与未处理组相比明显升高,胰岛素敏感性也随之上升;脂联素表达明显增高,与未处理组相比,差异有统计学意义;内脏脂肪素表达变化不明显,与未处理组相比,差异没有统计学意义。褪黑素、Neu-P11分别与褪黑素受体拮抗剂Luzindole联合作用于细胞后,细胞的脂联素表达水平与未加拮抗剂Luzindole的褪黑素、Neu-P11组相比明显下降,差异具有统计学意义,与未处理组相比,没有明显变化,差异没有统计学意义。因此,褪黑素和Neu-P11都可提高胰岛素抵抗脂肪细胞的胰岛素敏感性,增加糖消耗量,使脂联素表达上调,而对内脏脂肪素表达没有明显影响;褪黑素和Neu-P11可能是通过与褪黑素受体2(Mel1b)结合发挥上述作用的;褪黑素受体拮抗剂Luzindole能够阻断褪黑素和Neu-P11与褪黑素受体2(Mel1b)的结合。以上结果说明,Neu-P11和脂联素在治疗糖尿病方面都有着非常大的发展前景。 | 李秀平 蔡世昌 尹卫东 胡晓波 Moshe Laudon | 2013 | 生物物理学报2013，29，6： | 4 |
| 15 | 贝莱斯芽胞杆菌B006对不同水肥条件下娃娃菜生长及软腐病防效的影响显示文摘贝莱斯芽胞杆菌B006是一株高效生防菌株,但其在不同水肥条件下的防病促生效果尚不明确。本研究通过盆栽试验测定了不同土壤含水量和施肥条件下B006菌剂对娃娃菜生长及对软腐病防效的影响,结果表明:在土壤含水量为14%、施肥量为3.57 g/kg土的条件下,播种时沟施5 g B006菌剂(菌含量为1×10^(7)CFU/g),出苗后浇灌B006菌悬液(3×10^(8)CFU/m L)可明显降低娃娃菜的发病率和病情指数,与相同条件下未施用B006菌剂处理相比,防效达77.4%。在日光温室开展土壤水势、施肥量及B006菌剂施用随机区组交互试验,结果表明:在土壤水势-50 kPa和追肥量1049.5 kg/hm^(2)(N/P/K=18/5/13)条件下,施用B006菌剂可以促进植株生长,与土壤水势和追肥量分别为-50 kPa×1499.3 kg/hm^(2)和-30 kPa×1499.3 kg/hm^(2)的处理相比,娃娃菜产量分别提高了8.6%和11.2%。综上所述,适当少水、少肥并施用贝莱斯芽胞杆菌B006菌剂可以明显控制娃娃菜软腐病的发生,促进植物生长,并显著提高娃娃菜产量。 | 耿妍 张世昌 郭荣君 张爱香 Govrin Eri Moshe 李世东 沈瑞清 罗明 | 2021 | 中国生物防治学报2021，37，3： | 4 |
| 16 | 褪黑素受体激动剂Neu-P11对兔眼组织AQP1表达的影响显示文摘水通道蛋白1(aquaporin1,AQP1)在眼内组织分布较广,其与房水的分泌、排出及调节关系密切;褪黑素受体激动剂5-MCA—NAT能降低实验兔眼压;Neu-P11是一种高效的非选择性褪黑素受体激动剂,能激活褪黑素受体,从而起到类似褪黑素的作用; | 席守民 杨五彪 马灵筠 于乐 尹卫东 Moshe Laudon | 2013 | 中国药理学通报2013，29，9： | 4 |
| 17 | Neu-P11与褪黑素增强大鼠物体识别记忆显示文摘目的检测一种新颖的褪黑素受体激动剂Neu-P11与褪黑素对大鼠物体识别记忆的影响。方法大鼠物体识别测试包括两个阶段即4 min的训练期和3 min的测试期。在上午或下午于训练前2 h注射Neu-P11(50 mg/kg)、褪黑素(50 mg/kg)或溶媒。训练结束后4 h或24 h,分别检测大鼠的短时程与长时程记忆保持。记录并分析各组大鼠在训练期的总探究时间与测试期的辨别指数。结果在短时程记忆及长时程记忆测试中,无论上午或下午给药,各组大鼠在训练期间的总探究时间组间差异无显著性,且Neu-P11处理组大鼠其辨别指数均显著性高于溶媒组;褪黑素处理组大鼠仅在下午给药时其辨别指数显著性高于溶媒组。结论 Neu-P11与褪黑素均能增强大鼠物体识别记忆,且Neu-P11的效应是给药时间非依赖的。 | 王琳 田绍文 黄伏连 Laudon Moshe 欧阳新平 周寿红 | 2012 | 中南医学科学杂志2012，40，3： | 4 |
| 18 | Neu-P11对急性高眼压大鼠视网膜AQP4表达及眼内压的影响显示文摘水通道蛋白4(aquaporin4,AQP4)是视网膜上重要的水通道蛋白之一,参与房水的分泌和排出,有调节眼内水、电解质运输平衡的功能.褪黑素(melatonin,Mel)是松果体合成分泌的一种吲哚类神经内分泌激素,可以作为黄斑变性、青光眼以及心血管疾病的一种辅助治疗药物,具有降低眼内压(intraocular pressure,IOP)的作用. | 张瑶 张星慧 佘美华 尹卫东 杨娟 Moshe Laudon 石金凤 | 2016 | 中国药理学通报2016，32，11： | 4 |
| 19 | Older age, longer procedures and tandem endoscopic-ultrasound as risk factors for post-endoscopic retrograde cholangiopancreatography bacteremia显示文摘BACKGROUND Clinically significant post-endoscopic retrograde cholangiopancreatography(ERCP) bacteremia(PEB) occurs in up to 5% of cases, while antibiotic prophylaxis is recommended only when an ERCP is unlikely to achieve complete biliary drainage. However, the current recommendations may not cover all potential risk factors for PEB.AIM To identify novel risk factors for PEB and evaluate appropriateness of antibiotic prophylaxis.METHODS A retrospective study of 1082 ERCP procedures performed between January 2012-December 2013 in a single tertiary medical center. Data collection included: Demographic and clinical characteristics such as pre and post procedure antibiotic treatment and bacterial blood cultures. Exclusion criteria were:(1) Age < 18 years;(2) Positive bacterial blood culture before ERCP;(3) Scheduled antibiotic treatment prior to ERCP;(4) Hospitalization longer than 14 d before ERCP;and(5) missing critical data. Stepwise Logistic Regression analysis and Decision Tree algorithms were used for prediction modeling of PEB.RESULTS A total of 626 ERCPs performed in 434 patients were included. Mean age 66.49 ± 15.4 years and 46.5% were males. PEB prevalence was 3.7%. Antibiotic prophylaxis was administrated in 139/626(22.2%) cases but was indicated according to the guidelines only in 44/626(7%) cases. In all the PEB cases, prophylaxis was deemed not indicated. A stepwise logistic regression [receiver operating characteristic(ROC), 0.766], identified 3 variables as independent risk factors for PEB: Age at ERCP ≥ 75 years(OR, 3.780, 95%CI: 1.519-9.408, P = 0.004);Tandem EUS/ERCP with fine needle aspiration(FNA)(OR, 14.528, 95%CI: 3.571-59.095, P < 0.001);ERCP duration longer than 60 min(OR, 5.396, 95%CI: 1.86-15.656, P = 0.002). In a decision tree model(ROC, 0.778) the probability for PEB without any risk factors was 1% regardless of prophylaxis administration.CONCLUSION The prevalence of PEB in our study is similar to previous reports, despite the fact that antibiotic prophylaxis was administrated more readily than recommended. ERCP duration longer than 60 min, tandem EUS-ERCP with FNA and age above 75 years are significant risk factors for PEB. These factors should be further evaluated as indications for prophylactic antibiotic treatment before ERCP. | Liat Deutsch Shay Matalon Adam Phillips Moshe Leshno Oren Shibolet Erwin Santo | 2020 | World Journal of Gastroenterology2020，26，41： | 3 |
| 20 | 全球电子行业中的进化论显示文摘2009年,半导体企业甚至整个全球电子市场的经历用达尔文"适者生存"的理论来描述再合适不过的了。全球经济低迷加剧了本来就比较严峻的商业和技术的挑战。由于细分的消费市场变化无常、对高连接性和移动性需求的持续上升、上市时间的日益缩短、工程预算的不断萎缩, | Moshe Gavrielov | 2010 | 世界电子元器件2010，，1： | 3 |
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