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| 1 | 异型缝隙连接通道和磷酸化对心脏缝隙连接的调变显示文摘目的 检测由缝隙连接蛋白 (connexin ,Cx) 4 3和Cx4 5组成的多种异型缝隙连接通道 (het eromultimericgapjunctionchannels ,HGJC)和磷酸化对缝隙连接 (gapjunction ,GJ)的调变作用。方法 将转染了编码为Cx4 3或Cx4 5的DNA后的Hela细胞放置在一起共同培养组成双侧和单侧异型GJ通道。显微注射若丹明 12 3(rhodamine 12 3,Rh)检测经 2 0 0nmol/L十四 (烷 )酰佛波醇乙酸酯 (12 0 tetrade canoylphorbol 13 acetae ,TPA)处理前后 ,在紫外光显示下由Cx4 3和Cx4 5所组成的不同GJ通道对荧光染料的偶联率 (couplingratio)。结果 在不同的GJ中 ,同型GJ通道Cx4 3(homotypicCx4 3,HoCx4 3)偶联率最高。从Cx4 5侧注入荧光染料的单侧异型GJ通道 4 5 (mono heteromericCx4 5 Cx4 3/4 5 ,MH4 5 )偶联率较之从Cx4 3/4 5侧注入荧光染料的MH4 5、双侧异型GJ通道Cx4 3/4 5 (bi heteromericCx4 3/4 5 ,BH4 3/4 5 )及同型GJ通道Cx4 5 (homotypicCx4 5 ,HoCx4 5 )等的偶联率是最低的。根据HoCx4 3或HoCx4 5通道的偶联率对各型通道偶联率进行标准化处理。BH4 3/4 5和MH4 3通道的偶联率均较HoCx4 3降低。对MH4 5通道来说 ,从Cx4 3/4 5侧注射的通道偶联率大于从Cx4 5侧注射的偶联率。TPA处理后HoCx4 3的偶联率降低 。 | 钟国强 黄从新 刘唐威 Mantel PL Moreno AP | 2003 | 中华心律失常学杂志2003，7，4： | 9 |
| 2 | Intercellular communication through gap junctions:a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum 显示文摘 | Christ GJ Moreno AP Parker ME | 1991 | Life Sci1991，49，24： | 1 |
| 3 | Attractive bluegreen egg coloration and cuckoo-host coevolution显示文摘 | Soler JJ Avilés JM Moller AP Moreno J | | 0，，： | 1 |
| 4 | Gap junction channel gating modulated through protein phosphorylation显示文摘 | Moreno AP Lau AF | 2007 | Prog Biophy Mol Bio2007，94，： | 1 |
| 5 | Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins 显示文摘 | Moreno AP | 2004 | Cardiovase Res2004，62，2： | 1 |
| 6 | Bile acids affect liver mitochondrial bioenergetics:possible relevance for cholestasis therapy显示文摘 | Rolo AP Oliveira PJ Moreno AJ | 2000 | Toxicol Sci2000，57，1： | 1 |
| 7 | Gap junctions between cells expressing connexin 43 or 32 show inverse perselectivity to adenosine and ATP显示文摘 | Goldberg GS Moreno AP Lampe PD | 2002 | J Biol Chem2002，277，36： | 1 |
| 8 | International trends in the incidence of cervical cancer:I adenocarcinoma and adenosquamous cell carcinomas显示文摘 | Vizcaino AP Moreno V Bosch FX | 1998 | Int J Cancer1998，75，4： | 1 |
| 9 | Levosi- mendan:The current situation and new prospects显示文摘 | Moreno N Tavares-Silva M Lourenco AP | 2014 | Rev Port Cardiol2014，33，12： | 1 |
| 10 | Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation显示文摘 | Martinez AD Hayrapetyan V Moreno AP | 2002 | Circ Res2002，90，： | 1 |
| 11 | Opposing gates model for voltage gating of gap junction channels显示文摘 | Chen-Izu Y Moreno AP Spangler RA | 2001 | Am J Physiol Cell Physiol2001，281，： | 1 |
| 12 | Gap junction-mediated intercellular diffusion of Ca2 + in cultured human corporal smooth muscle cells显示文摘 | Christ GJ Moreno AP Melman A | 1992 | Am J Physiol1992，263，21： | 1 |
| 13 | Role of the Carboxyl Terminal of Connexin43 in Transjunctional Fast Voltage Gating显示文摘 | Moreno AP Chanson M Anumonwo J | 2002 | Circ Res2002，90，： | 1 |
| 14 | Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973 - 1995 显示文摘 | Vizcaino AP Moreno V Lambert R | 2002 | Int J Cancer2002，99，6： | 1 |
| 15 | Sagittal plane deformi- ty in the adult patient显示文摘 | Joseph SA Jr Moreno AP Brandoff J | 2009 | J Am Acad Orthop Surg2009，17，6： | 1 |
| 16 | Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy 显示文摘 | Rolo AP Oliveira PJ Moreno AJ | 2000 | Toxicol Sci2000，57，1： | 1 |
| 17 | Time trends incidence of both major histologic types of esophageal carcinomas in selected countries,1973-1995显示文摘 | Vizcaino AP Moreno V Lambert R | 2002 | Int J Cancer2002，99，6： | 1 |
| 18 | Gap junction channels:Distinct voltage-sensitive and insensitive conductance states显示文摘 | Rook MB Fishman GI | 1994 | Biophys J1994，67，： | 1 |
| 19 | Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound:early development in a porcine model of vulnerable plaque显示文摘 | Granada JF Moreno PR Burke AP Schulz DG Raizner AE Kaluza GL | 2005 | Coron Artery Dis2005，16，4： | 1 |
| 20 | International trends incidence of cervical cancer: Squamous cell carcinoma显示文摘 | Vizcaino AP Moreno V Bosch FX | 2002 | Int J Cancer2002，86，3： | 1 |
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