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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | A short review of malabsorption and anemia显示文摘Anemia is a frequent finding in most diseases which cause malabsorption. The most frequent etiology is the combination of iron and vitamin B12 deficiency. Celiac disease is frequently diagnosed in patients referred for evaluation of iron deficiency anemia (IDA), being reported in 1.8%-14.6% of patients. Therefore, duodenal biopsies should be taken during endoscopy if no obvious cause of iron defi ciency (ID) can be found. Cobalamin defi ciency occurs frequently among elderly patients, but it is often unrecognized because the clinical manifestations are subtle; it is caused primarily by food-cobalamin malabsorption and pernicious anemia. The classic treatment of cobalamin deficiency has been parenteral administration of the vitamin. Recent data suggest that alternative routes of cobalamin administration (oral and nasal) may be useful in some cases. Anemia is a frequent complication of gastrectomy, and has been often described after bariatric surgery. It has been shown that banding procedures which maintain digestive continuity with the antrum and duodenum are associated with low rates of ID. Helicobacter pylori (H pylori) infection may be considered as a risk factor for IDA, mainly in groups with high demands for iron, such as some children and adolescents. Further controlled trials are needed before making solid recommendations about H pylori eradication in these cases. | Fernando Fernández-Baares Helena Monzón Montserrat Forné | 2009 | World Journal of Gastroenterology2009，15，37： | 6 |
| 3 | Sports-related sudden cardiac death due to myocardial diseases on a population from 1-35 years: a multicentre forensic study in Spain显示文摘This is a multicentre forensic study that identifies all sports-related sudden deaths (SRSDs) in young people,due to myocardial diseases (MDs) that occurred in a large area of Spain.The aim of the study is to assess the epidemiology,causes of death,and sport activities associated with these fatalities.This is a retrospective study based on forensic autopsies performed in the provinces of Biscay,Seville,Valencia and in the jurisdiction covered by the National Institute of Toxicology and Forensic Sciences in Madrid (Spain).The retrospective study encompasses from 2010 to 2017.All sudden cardiac deaths (SCDs) in persons 1-35years old were selected.The total number of SCDs were divided into death occurred during exercise (SRSD) and death during rest,sleep or normal activities (non-SRSD).Each of these two groups was subdivided according to the cause of death into MD (primary cardiomyopathies and myocarditis) and non-MD.Clinic-pathological,toxicological and genetic characteristics of SRSD due to MD were analysed.Over the 8-year study period,we identified 645 cases of SCD in the young: 75 SRSD (11.6%) and 570 non-SRSD (88.4%).MD was diagnosed in 33 (44.0%) of the SRSD and in 112 (19.6%) of the non-SRSD cases.All cases of SRSD due to MD were males (mean age (24.0±7.6) years) practicing recreational sports (85%).SRSDs were more frequent in arrhythmogenic cardiomyopathy (ACM) (37%) and hypertrophic cardiomyopathy (HCM) (24%),followed by myocarditis (15%) and idiopathic left ventricular hypertrophy (ILVH) (9%).Only in five cases of SRSD the MD responsible of death (HCM) had been diagnosed in life.Cardiovascular symptoms related to the disease were present in other seven patients (six of them with ACM).Postmortem genetic studies were performed in 15/28 (54%) primary cardiomyopathies with positive results in 12 (80%) cases.The most frequent sports disciplines were football (49%) followed by gymnastics (15%) and running (12%).In Spain,SRSD in young people due to MDs occurs in males who perform a recreational activity.Compared with control group we observed a strong association between MDs and exertion.One in three SRSDs are due to cardiomyopathy,especially ACM,which reinforces the need for preparticipation screening to detect these pathologies in recreational sport athletes.Further studies are warranted to understand the causes and circumstances of sudden death to facilitate the development of preventive strategies. | Benito Morentin M.Paz Suárez-Mier Ana Monzó Pilar Molina Joaquín S.Lucena | 2019 | Forensic Sciences Research2019，4，3： | 6 |
| 4 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 5 | Efficiency and spatial equity impacts of high-speed rail extensions in urban areas显示文摘 | Andrés Monzón Emilio Ortega Elena López | 2013 | Cities2013，，： | 2 |
| 6 | Surgical, oncological, and obstetrical outcomes after abdominal radical trachelectomy — A systematic literature review显示文摘 | René Pareja Gabriel J. Rendón Carlos Millán Sanz-Lomana Otto Monzón Pedro T. Ramirez | 2013 | Gynecologic Oncology2013，，： | 2 |
| 7 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 8 | The PrfA virulence regulon显示文摘 | SCORTTI M MONZ H J LACHARME-LORA L | 2007 | Microbes Infect2007，9，10： | 1 |
| 9 | Spatial patterns of recreation impact on experimental camp sites显示文摘 | Cole D N Monz C A | 2004 | Environmental Management2004，70，1： | 1 |
| 10 | Prescribing patterns of antidepressants in Europe : results from the Factors Influencing Depression Endpoints Research (FINDER) study显示文摘 | BAUER M MONZ BU MONTEJO AL | 2008 | Eur Psychiatry2008，23，1： | 1 |
| 11 | Radial glial cells,proliferating periventricular cells,and microglia might contribute to successful structural repair in the cerebral cortex of the lizard Gallotia galloti显示文摘 | Romero-Alemán M M Monz'on-Mayor M Yanes C | 2004 | Experimental Neurology2004，188，1： | 1 |
| 12 | Dihydropyrim - Idine de- hydrogenases and cytidine - deaminase gene polymor - phisms as outcome predictors in resected gastric cancer pa - tients trea- ted with fluoropyrimidine adjuvant chemotherapy显示文摘 | Grau JJ Caballero M Monz? M | 2008 | J' Surg On- col2008，98，2： | 1 |
| 13 | High FSH:LH ratio and low LH levels in basal cycle day 3:impact on follicular development and IVF outcome显示文摘 | Barroso G Oehninger S Monzó A | | 0，，09： | 1 |
| 14 | A new concept for interactive radiotherapy planning with multicriteria optimization:first clinical evaluation显示文摘 | Thieke C Küfer KH Monz M | | 0，，： | 1 |
| 15 | Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions显示文摘 | N. Ramírez E. Bandrés A. Navarro A. Pons S. Jansa I. Moreno F. Martínez-Rodenas R. Zárate N. Bitarte M. Monzó J. García-Foncillas | 2008 | European Journal of Cancer2008，，17： | 1 |
| 16 | Document understanding for a broad class of documents 显示文摘 | Aiello M Monz C Todoran L | 2002 | International Journal on Document Analysis and Recognition2002，5，1： | 1 |
| 17 | Correlates of sexually related personal distress in women with low sexual desire 显示文摘 | Rosen RC Shifren JL Monz BU | 2009 | J Sex Med2009，6，6： | 1 |
| 18 | Weekly paclitaxel for platin-resistant stage IV head and neck cancer patients显示文摘 | Juan josé Grau Miguel Caballero Eugenia Verger Mariano Monzó Jose luís Blanch | 2009 | Acta Oto-Laryngologica2009，，： | 1 |
| 19 | A novel anti-apoptosis re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancer显示文摘 | Monz M Rafael R Enrigueta F | 1999 | J Clin Oncol1999，17，7： | 1 |
| 20 | A novel anti-apoptosis gene:re-expression of surviving messenger RNA as a prognosis marker in non-small-cell lung cancers显示文摘 | Monzó M Rosell R Felip E | 1999 | J clin oncol1999，17，7： | 1 |
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