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| 1 | Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B_(12) status显示文摘AIM:To evaluate joint effects of Methylentetra-hydrofolate reductase(MTHFR) C677T genotypes,and serum folate/vitamin B12 concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS:We examined the associations between MTHFR C677T genotype,and promoter methylation of P16,hMLH1,and hMSH2 tumor-related genes among151 sporadic colorectal cancer patients. The promoter methylation of tumor-related genes was determined by methylation-specific PCR. Eighty six patients from whom fresh tumor samples were obtained and 81 controls were also examined for serum folate and vitamin B12 concentrations by a commercial radioimmunoassay kit. RESULTS:We found 29.1% of cases had tumors with at least one methylated gene promoter. In case-case comparison,we did not find a significant association between methylation in tumors and any single genotype. However,in comparison to controls with the CC genotype,an increased risk of tumor methylation was associated with the CT genotype(OR = 2.5;95% CI,1.1-5.6) . In case-case comparisons,folate/vitamin B12 levels were positively associated with tumor methylation. Adjusted odds ratios for tumor methylation in cases with high(above median) versus low(below median) serum folate/vitamin B12 levels were 4.9(95% CI,1.4-17.7) ,and 3.9(95% CI,1.1-13.9) ,respectively. The frequency of methylated tumors was significantly higher in high methyl donor than low methyl donor group,especially in those with MTHFR CT(P = 0.01) ,and CT/TT(P = 0.002) genotypes,but not in those with the CC genotype(P = 1.0) . CONCLUSION:We conclude that high concentrations of serum folate/vitamin B12 levels are associated with the risk of promoter methylation in tumor-specific genes,and this relationship is modified by MTHFR C677T genotypes. | Pooneh Mokarram Fakhraddin Naghibalhossaini Mehdi Saberi Firoozi Seyed Vahid Hosseini Ahmad Izadpanah Heshmetalah Salahi Seyed Ali Malek-Hosseini Abdoulrasool Talei Mehra Mojallal | 2008 | World Journal of Gastroenterology2008，14，23： | 5 |
| 2 | Distinct high - profile meth- ylated genes in eoloreetaleancer 显示文摘 | Mokarram P Kumar K Brim H | 2009 | PLoS One2009，4，9： | 1 |
| 3 | Impact of BRAF, MLH1 on the incidence of microsatellite instabilily high colorectal cancer in populations based study显示文摘 | Brim H Mokarram P Naghibalhossaini F | 2008 | Mol cancer2008，7，： | 1 |
| 4 | Distinct high-profile methylated genes in colorectal cancer显示文摘 | Mokarram P Kumar K Brim H | 2009 | PLoS One2009，4，9： | 1 |
| 5 | Distinct high- profile methylated genes in colorectal cancer显示文摘 | Mokarram P Kumar K Brim H | 2009 | PLoS One2009，114，9： | 1 |
| 6 | MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients显示文摘 | Naghibalhossaini F Mokarram P Khalili I | 2010 | Cancer Genet Cytogenet2010，197，2： | 1 |
| 7 | DNMT3b- 149C/T promoter variants and methylation of colorectal cancer- associated genes显示文摘 | Naghibalhossaini F Mokarram P Khalili E | 2015 | Cancer Biomark2015，15，3： | 1 |
| 8 | Impact of BRAF,MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study显示文摘 | Brim H Mokarram P Naghibalhossaini F | 2008 | Mol Cancer2008，7，5： | 1 |
| 9 | Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study 显示文摘 | Brim H Mokarram P Naghibalhossaini F | 2008 | Mol Cancer2008，，7： | 1 |
| 10 | Overcoming endogenous constraints on neuronal regeneration 显示文摘 | Mokarram N Bellamkonda R V | 2011 | IEEE Trans Biomed Eng2011，58，7： | 1 |
| 11 | The influence of multi stage alginate coating on survivability of potential probiotic bacteria in simulated gastric and intestinal juice显示文摘 | Mokarram R R Mortazavi S A Najafi M B H | 2009 | Food Research International2009，42，8： | 1 |
| 12 | Hyperelastic models for rubber-like materials: consistent tangent operators and suitability for Treloar’s data显示文摘 | Paul Steinmann Mokarram Hossain Gunnar Possart | 2012 | Archive of Applied Mechanics2012，，9： | 1 |
| 13 | Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70显示文摘 | Majid Tebianian Ahmad Zavaran Hoseini Seyyed Mahmoud Ebrahimi Arash Memarnejadian Ali Rezaei Mokarram Mehdi Mahdavi Nooshin Sohrabi Morteza Taghizadeh | 2011 | Biologicals2011，，3： | 1 |
| 14 | Land suitability evaluation using ordered weight averaging with fuzzy quantifier in Shavoor Plain, Iran显示文摘 | Mokarram M Askari M S Moezi A A | 2011 | Research on Crops2011，12，2： | 1 |
| 15 | Impact of BRAF, MLH1 on the incidence of microsatellite instabil- ity high colorectal cancer in populations based study显示文摘 | Rim H Mokarram P Naghibalhossaini F | 2008 | Mol Cancer2008，7，： | 1 |
| 16 | Effects of body electroacupuncture on plasma leptin concentrations in obese and overweight people in Iran:a randomized controlled trial显示文摘 | Darbandi S Darbandi M Mokarram P | 2013 | Alternative therapies in health and medicine2013，19，2： | 1 |
| 17 | Application of whey in fermented beverage production using kefir star- ter culture 显示文摘 | Assadi M M Abdolmaleki F Mokarrame R R | 2008 | Nutrition and Food Science2008，38，2： | 1 |
| 18 | Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study显示文摘 | BRIM H MOKARRAM P NAGHIBALHOSSAINI F | 2008 | Mol Cancer2008，7，： | 1 |
| 19 | HER-2/neu and E-cadher- in Expression and Microsatellite Instability in Gastric Dysplasia显示文摘 | Ahmadi L Kamkari S Mokarram P | 2011 | Middle East J Dig Dis2011，3，1： | 1 |
| 20 | MGMT-B Gene Promoter Hypermethylation in Patients with Inflammatory Bowel Disease-A Novel Finding显示文摘 | Mokarram P1 Kavousipour S Sarabi MM | 2015 | Asian Pac J CancerP rev2015，，5： | 1 |
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