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| 1 | Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma显示文摘AIM To investigate the effect of lycopene extracted from tomatoes(LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine(NDEA)-induced hepatocarcinogenesis. METHODS Female BALB/c mice were randomly divided into four groups: The Control, NDEA(200 mg NDEA/kg b.w. given i.p.), LycT(5 mg/kg b.w. given orally on alternate days) and Lyc T + NDEA group. The m RNA and protein expression of various cell proliferation markers(PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd.(India). RESULTS Uncontrolled proliferation in the liver of NDEA(P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes(PCNA, Cyclin D1, and p21) when compared to control and Lyc T mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphatedehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control(P ≤ 0.001) and Lyc T(P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. Lyc T pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the Lyc T + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma(HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group. CONCLUSION This study demonstrates that dietary supplementation with Lyc T has a multidimensional role in preventing HCC development. | Prachi Gupta Nisha Bhatia Mohinder Pal Bansal Ashwani Koul | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Lance Adams syndrome: Difficulties surrounding diagnosis, prognostication, and treatment after cardiac arrest显示文摘 | Suchitra Malhotra Kumar Mohinder | 2012 | Anesthesia:Essays and Researches2012，6，2： | 1 |
| 3 | Effect of branch position and auxin treatment on clonal propagation of Tectona grandis Linn. f.显示文摘 | Azamal Husen Mohinder Pal | 2007 | New Forests2007，，3： | 1 |
| 4 | Katou:Strateic determinantsfor the selection of partner alliances in the Indian touroperator industry : A cross-national study 显示文摘 | Mohinder Chand Anastasia A | 2012 | Journal ofWorld Business2012，47，2： | 1 |
| 5 | Early Predictors of 15-Year End-Stage Renal Disease in Hypertensive Patients显示文摘 | Jr Perry J. Philip Miller Jane Rossiter Fornoff Jack D. Baty Mohinder P. Sambhi Gale Rutan David W. Moskowitz Sharon E. Carmody | 1995 | Hypertension1995，，4： | 1 |
| 6 | Application of Kalman Filtering to the calibration and alignment of inertial navigation systems显示文摘 | Mohinder S G Vinson D H Randy S M | 1991 | IEEE Transactions on Automatic Control1991，36，1： | 1 |
| 7 | Ranganathan and the Public Library Legislation in India 显示文摘 | Mohinder Partap Satija | 1987 | Libri: International library review vol 37 num 41987，1987，： | 1 |
| 8 | How certain firm-specific characteristics affect the accuracy and dispersion of analysts’ forecasts显示文摘 | Mohinder Parkash | 1995 | Journal of Business Research1995，，3： | 1 |
| 9 | Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol–polysorbate 80 mixture显示文摘 | Hemant N Joshi Ravindra W Tejwani Martha Davidovich Vaishali P Sahasrabudhe Mohammed Jemal Mohinder S Bathala Sailesh A Varia Abu T.M Serajuddin | 2003 | International Journal of Pharmaceutics2003，，1： | 1 |
| 10 | Effect of selenium-inducedoxidative stress on the cell kinetics in testis and reproductive ability ofmale mice显示文摘 | Parminder Kaur M Sc Mohinder P Bansal | 2005 | Nutriton2005，21，： | 1 |
| 11 | Measuring the service quality of Indian tourism destinations: an application of SERVQUAL model 显示文摘 | Chand Mohinder | 2010 | Service Technology and Management2010，12，34： | 1 |
| 12 | Rayleigh-Lamb waves in homogeneous isotropic plate显示文摘 | Pal Mohinder Sharma magneto-thermoelastic J N | 2004 | International Journal of Engineering Science2004，42，2： | 1 |
| 13 | Role of selenium in spermatogenesis: Differential expression of cjun and cfos in tubular cells of mice testis显示文摘 | Sonia Shalini Mohinder P. Bansal | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 14 | Role of selenium in spermatogenesis: Differential expression of cjun and cfos in tubular cells of mice testis显示文摘 | Sonia Shalini Mohinder P. Bansal | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 15 | Kalman Filter Implementation With Improved Numerical Properties显示文摘 | Mohinder S.Grewal James Kain | | 0，，09： | 1 |
| 16 | Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice显示文摘 | Parminder Kaur Mohinder P. Bansal | 2005 | Nutrition2005，，3： | 1 |
| 17 | Water resource management for sustainable agricul- tare in Punjab, India显示文摘 | Rajah Aggarwal Mohinder Kaushal Kaur Samanpreet | 2009 | Water Science and Technolo- gy2009，60，11： | 1 |
| 18 | Production and characterization of elatase Bacillus subtilis isolated from the cervices of human females Can显示文摘 | Mohinder Kaur Tripashi K K | 1988 | Microbiol1988，34，： | 1 |
| 19 | Fundamentals of wideband stripline directional coupler design显示文摘 | Har Mohinder Singh John Howard | 1989 | Mi- crowave Journal1989，32，11： | 1 |
| 20 | The agricultural demand for electricity in the United States 显示文摘 | Noel D Uri Mohinder Gill | 1995 | International Journal of Ener- gy Research1995，19，2： | 1 |
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