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您的检索式：作者名="Mohan Kumar RAI"
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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Use of the Max Ent model to predict changes in sloth bear(Melursus ursinus)habitats in the Gandaki River Basin,Nepal显示文摘The Gandaki River Basin(GRB),located in the central Himalaya,provides habitats for a large number of important flora and fauna species.The habitats of key protected species have changed over time as a result of climate changes and human activities related to land use change,including the development of roads.This study assessed the present and future distributions of sloth bear(Melursus ursinus)habitats using the maximum entropy(Max Ent)model.Bioclimatic data,a digital elevation model and roads were used as environmental layers to assess current and future distributions of habitat.Results show that the overall habitat within the study area is likely to undergo important changes in the future.Bio 8(the mean temperature of the wettest quarter)and slope were found to be important variables affecting the distribution of the species.The habitats very highly suitable for sloth bears currently cover an area of 148 km^(2) within the GRB.These habitats are predicted to increase by 122 km^(2) more by 2050.Overall,a net change by 680.38 km^(2) was found in the GRB.Conservation measures are necessary for this key protected species and its habitat within the GRB and elsewhere in Nepal. | Raju RAI ZHANG Yi-li WANG Zhao-feng Basanta PAUDEL LIU Lin-shan Mohan Kumar RAI Narendra Raj KHANAL | 2022 | Journal of Mountain Science2022，19，7： | 1 |
| 3 | Long-term effect of different integrated nutrient management on soil organic carbon and its fractions and sustainability of rice–wheat system in Indo Gangetic Plains of India显示文摘 | A.K. Nayak B. Gangwar Arvind K. Shukla Sonali P. Mazumdar Anjani Kumar R. Raja Anil Kumar Vinod Kumar P.K. Rai Udit Mohan | 2011 | Field Crops Research2011，，： | 1 |
| 4 | Distinct Role of Core Promoter Architecture in Regulation of Light-Mediated Responses in Plant Genes显示文摘在现在的学习,我们选择了调整光的倡导者的四个不同的类。bedistinctly 组织进任何一个 TATA-box-containing 或 TATA 少些的调整光的倡导者罐头(包含开始者) 倡导者。进一步,使用本国的倡导者或他们核心 promoterelements 的交换版本,我们建立了元素有的那个 TATA 盒子和 Inr (开始者) 涉及调停光的规定的不同机制,和这些元素是 notswappable。我们鉴别在功能的 TATA 盒子或 Inr 元素的变化导致 nucleosomal 结构的形成。在在 Arabidopsis 生态型的 TATA 盒子或 Inr 元素的核苷酸差异建议在核心倡导者的核苷酸变化能改变基因表示。我们显示出那主题 overrepresentationin 激活光的倡导者包含下游地在场的不同特定的规章的主题 TSS (抄写 startsite ) ,和这力量在调整与这些元素平行的轻倡导者用作一个关键因素。最后,我们断定 TATA 盒子或 Inr 元素不清楚地在隔离,而是我们的结果行动与 TATA 盒子或 Inr 元素在同时发生建议另外的不同核心 promoterelements 的可能的参与给予选择到调停光的 transcription.Key 词: | Rakesh Srivastava Krishan Mohan Rai Meenal Srivastava Verandra Kumar Bindu Pandey Sudhir P. Singh Sumit K. Bag Brahma Deo Singh Rakesh Tuli Samir V. Sawant | 2014 | Molecular Plant2014，7，4： | 1 |
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