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| 1 | 医学专业本科留学生教育限制性因素调查分析及对策建议显示文摘目的对留学生医学教育发展的限制性因素进行调查。方法2011至2013年对重庆医科大学350名在校留学生进行现场问卷调查,回收有效答卷339份。结果调查发现,仅有33.0%(112人)的学生认为授课教师英语表达较为顺畅,70.2%(238人)的学生有增加中文课的需求。另外,被调查学生中认为理论知识教育不够以及动手机会太少的分别占69.6%(236人)和63.1%(214人)。92.3%(313人)的学生来自东南亚地区等发展中国家。86.1%(292人)的学生认为学校对其管理不足。结论通过此次调查发现。影响留学生医学教育发展的因素主要有语言水平与需求不平衡、专业知识教育及实践不足、生源问题以及日常管理中的困难等。 | 谭继翔 张丹 赵林 刘景仑 王栋 Islam Mohammed Aftab Chouhan Dawood Siddiqui | 2016 | 中华医学教育探索杂志2016，15，2： | 14 |
| 2 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 3 | Predictive factors for early aspiration in liver abscess显示文摘AIM: To determine the predictive factors for early aspiration in liver abscess. METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess. RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group. CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology. | Rustam Khan Saeed Hamid Shahab Abid Wasim Jafri Zaigham Abbas Mohammed Islam Hasnain Shan Shaalan Beg | 2008 | World Journal of Gastroenterology2008，14，13： | 8 |
| 4 | 重庆医科大学医学专业留学生调研与分析显示文摘为了解重庆医科大学医学留学生教育相关情况,采用问卷调查和目的谈话的方式,对在重庆医科大学学习的医学留学生的来华留学原因、学习动机、语言水平、学习需求、学习中的困难及解决办法、英语授课和评价、毕业后就业取向以及对中国文化的兴趣等方面,进行全面调研与分析,对相关问题进行总结,并对今后的留学生教育提出改进计划。 | 赵林 王栋 李鹏飞 刘晓琴 刘景仑 Islam MOHAMMED Aftab CHOUHAN 张丹 | 2011 | 中华医学教育探索杂志2011，10，12： | 8 |
| 5 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 6 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 7 | Phytochemical analysis and antioxidant profile of methanolic extract of seed, pulp and peel of Baccaurea ramiflora Lour.显示文摘Objective: To analyze the phytochemical constituents responsible for the plausible antioxidant effect of methanolic extract of the seed, pulp and peel of Baccaurea ramiflora Lour. Methods: Fresh seed, pulp, and peel of Baccaurea ramiflora fruits were extracted with methanol(MEBRse, MEBRpu, MEBRpe) and evaluated by phytochemical analysis for their content of innumerable metabolites(primary and secondary) viz. carbohydrates, alkaloids, glycosides, tannins, phenols, terpenoids, flavonoids, proteins, and fixed oils. The antioxidant efficacy was assessed through different assay methods viz. 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activity, total antioxidant capacity(TAC) and reducing power capacity(RPC). Estimation of total phenolic content(TPC), and total flavonoid content(TFC) was also done to confirm the presence of these phytochemicals. Results: It was revealed from the phytochemical analysis of MEBRse that alkaloids, glycosides, carbohydrates, phenols, and flavonoids were present, while that of MEBRpu showed the existence of carbohydrates, proteins, alkaloids, glycosides, phenols, saponins, flavonoids, and fixed oils. Presence of carbohydrates, alkaloids, phenols, tannins, flavonoids, and terpenoids were found in the MEBRpe. A significant antioxidant activity was revealed by the MEBRpu [EC_(50):(27.612 ± 1.375) μg/mL], compared to MEBRpe, and MEBRse in DPPH assay. The ranking order for RPC was MEBRpu > MEBRpe > MEBRse respectively. The EC_(50) value of TAC of the MEBRpu, MEBRpe, and MEBRse were(25.107 ±0.744) μg/mL,(241.127 ± 7.463) μg/mL and(372.364 ± 11.030) μg/mL, respectively. Quantity of TPC and TFC were the highest in the MEBRpu(124.360 ± 2.078 mg GAE/g and 107.527 ±1.900 mg QRE/g extract) rather than MEBRpe and MEBRse extracts. Conclusions: This study suggests that MEBRpu has a significantly higher antioxidant property than MEBRpe and MEBRse. These extracts might be advantageous in prevention or decelerating the progress of different diseases related to oxidative-stress/damage. Moreover, detailed analysis of these extracts is required to identify the presence of promising compound(s) responsible for their antioxidant activity. | Md.Sahab Uddin Md.Sarwar Hossain Abdullah Al Mamun Devesh Tewari Md.Asaduzzaman Md.Siddiqul Islam Mohamed M.Abdel-Daim | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，7： | 3 |
| 8 | Dengue epidemiology and pathogenesis:images of the future viewed through a mirror of the past显示文摘Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs. | Rashedul Islam Mohammed Salahuddin Md.Salahuddin Ayubi Tahmina Hossain Apurba Majumder Andrew W.Taylor-Robinson Abdullah Mahmud-Al-Rafat | 2015 | Virologica Sinica2015，30，5： | 2 |
| 9 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 10 | An alternative derivation of modified gain function of Song and Speyer显示文摘 | Peggy J Galkowski Mohammed Islam | 1991 | IEEE Transactions on Automatic Control1991，36，11： | 1 |
| 11 | Fabrication, synthesis and mechanical characterization of nanoparticles infused polyurethane foams显示文摘 | Hassan Mahfuz Vijaya K Rangari Mohammed S Islam | 2004 | Composites: Part A2004，35，： | 1 |
| 12 | Thermal performance of a linear fresnel reflector solar concentrator using a black liquid显示文摘 | Mohammed Nurul Islam B S Negi Kandpal T C | 1992 | Renewable Energy1992，2，45： | 1 |
| 13 | Unsteady hydromechanics of a steering podded propeller unit 显示文摘 | Liu Pengfei Islam Mohammed Veitch Brian | 2009 | Ocean Engineering2009，36，1213： | 1 |
| 14 | A review of recent advances in 3D ear and expression invariant face biometrics显示文摘 | Syed MS Islam Mohammed Bennamoun Robyn A Owens | 2012 | ACM Computing Surveys2012，44，3： | 1 |
| 15 | GIS-modelling of the Spatial Variability of Flash Flood Hazard in A bu Dabbab Catchment, Red Sea Region, Egypt 显示文摘 | Islam A E Elsayed H Mohammed E B | 2010 | The Egyptian Journal of Remote Sensing and Space Sciences2010，，13： | 1 |
| 16 | An HDMI Cable E- qualizer With Self-Generated Energy Ratio Adaptation Scheme 显示文摘 | Liu Hao Mohammed Islam Fan Yanli | 2009 | IEEE TRANSACTIONS Transactions on Cir- cuits and Systems-II: Express Briefs2009，56，7： | 1 |
| 17 | Spatial distribution and source apportionment of heavy metals in soils of Gebeng industrial city, Malaysia显示文摘 | Mohammed Amjed Hossain Nasly M. Ali Mir Sujaul Islam H. M. Zakir Hossain | 2015 | Environmental Earth Sciences2015，，1： | 1 |
| 18 | Biocatalytic transformation of cyclohexanone by Fusarium SP显示文摘 | Deendayal Mandal Absar Ahamad Mohammed Islam Khan | 2002 | Journal of Molecular Catalysis Chemical2002，181，12： | 1 |
| 19 | Electrodes based on nano-tree-like vanadium nitride and carbon nanotubes for micro-supercapacitors显示文摘Vanadium nitride(VN) was deposited by DC-sputtering on a vertically aligned carbon nanotube(CNTs)template for the purpose of nano-structuration. This led to the fabrication of hierarchically composite electrodes consisting of porous and nanostructured VN grown on vertically aligned CNTs in a nano-treelike configuration for micro-supercapacitor application. The electrodes show excellent performance with an areal capacitance as high as 37.5 m F cm^(-2) at a scan rate of 2 mV s^(-1) in a 0.5 MK_2SO_4 mild electrolyte solution. Furthermore, the capacitance decay was only 15% after 20,000 consecutive cycles. Moreover,the capacitance was found to increase with VN deposit thickness. The X-ray photoelectron spectroscopy analyses of the electrodes before and after cycling suggest that the oxide layers that form at the VN surface is the responsible for the redox energy storage in this material. Such electrodes can compete with other transition metal nitride based electrodes for micro-supercapacitors. | Nadir Ouldhamadouche Amine Achour Raul Lucio-Porto Mohammad Islam Shahram Solayman Ali Arman Azin Ahmadpourian Hamed Achour Laurent Le Bri-zoual Mohamed Abdou Djouadi Thierry Brousse | 2018 | Journal of Materials Science & Technology2018，34，6： | 1 |
| 20 | Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum显示文摘Objective:To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract ofDesmodium puchellum(Family:Fabaceae)leaves.Methods:The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats.Both of the extracts were given to the rats at 200 mg/kg orally.Loperamide was used as a standard drug for diarrhea.Results:The diarrheal severity was reduced significantly(P<0.05)by methanol and petroleum ether extracts by 31.95% and 28.33%,respectively,whereas 54.75% inhibition was found for standard drug loperamide at 5 mg/kg.The two extracts also significantly(P<0.05) reduced the intestinal volume in case of castor oil induced enteropooling.Conclusions:It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential. | Md.Khalilur Rahman Soumitra Barua Md.Fokhrul Islam Md.Rafikul Islam Mohammed Abu Sayeed Mst.Shahnaj Parvin Md.EkramulIslam | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 1 |
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