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| 1 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 2 | Influence of Shim Layers on Progressive Failure of a Composite Componentin Composite-Aluminum Bolted Joint in Aerospace Structural Assembly显示文摘The influence of varying shim layers on the progressive damage/failure of a composite component in a bolted composite-aluminum aerospace structural assembly was investigated using a non-linear three-dimensional(3 D)structural solid elements assembled model of a carbon fiber-reinforced polymer(CFRP)-aluminum single-lap joint with a titanium(Ti-6 Al-4 V)fastener and a washer generated with the commercial finite element(FE)software package,ABAQUS/Standard.A progressive failure algorithm written in Fortran code with a set of appropriate degradation rules was incorporated as a user subroutine in ABAQUS to simulate the non-linear damage behavior of the composite component in the composite-aluminum bolted aerospace structure.The assembled 3 DFE model simulated,as well as the specimen for the experimental testing consisted of a carbon-epoxy IMS-977-2 substrate,aluminum alloy 7075-T651 substrate,liquid shim(Hysol EA 9394),solid peelable fiberglass shim,a titanium fastener,and a washer.In distinction to previous investigations,the influence of shim layers(liquid shim and solid peelable fiberglass shim)inserted in-between the faying surfaces(CFRP and aluminum alloy substrates)were investigated by both numerical simulations and experimental work.The simulated model and test specimens conformed to the standard test configurations for both civil and military standards.The numerical simulations correlated well with the experimental results and it has been found that:(1)The shimming procedure as agreed upon by the aerospace industry for the resolution of assembly gaps in bolted joints for composite materials is the same for a composite-aluminum structure;liquid shim series(0.3,0.5 and 0.7 mm thicknesses)prolonged the service life of the composite component whereas a solid peelable fiberglass shim most definitely had a better influence on the 0.9 assembly gap compared with the liquid shim;(2)The shim layers considerably influenced the structural strength of the composite component by delaying its ultimate failure thereby increasing its service life;and(3)Increasing the shim layer′s thickness led to a significant corresponding effect on the stiffness but with minimal effect on the ultimate load. | Cephas Yaw Attahu An Luling Li Zhaoqing Gao Guoqiang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 2 |
| 3 | A syetem for supporting rapid assembly modeling of mechanical products via components with typical assembly features显示文摘 | Li Guidong Zhou Laishui An Luling | 2010 | International Journal of Advanced Manufacturing Technology2010，46，： | 1 |
| 4 | A system for supporting rapid assembly modeling of mechanical products via components with typical assembly features显示文摘 | Li Guidong Zhou Laishui An Luling | | 0，，5： | 1 |
| 5 | A System for Supporting Rapid Assembly Modeling of Mechanical Products Via Components with Typical Assembly Features 显示文摘 | Li Guidong Zhou Laishui An Luling | 2010 | The International Journal of Advanced Manufacturing Technology2010，46，5678： | 1 |
| 6 | LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway显示文摘Aberrant activation of the WNT signaling pathway is a joint event in colorectal cancer(CRC),but the molecular mechanism is still unclear.Recently,RNA-splicing factor LSM12(like-Sm protein 12)is highly expressed in CRC tissues.This study aimed to verify whether LSM12 is involved in regulating CRC progression via regulating the WNT signaling pathway.Here,we found that LSM12 is highly expressed in CRC patient-derived tissues and cells.LSM12 is involved in the proliferation,invasion,and apoptosis of CRC cells,similar to the function of WNT signaling in CRC.Furthermore,protein interaction simulation and biochemical experiments proved that LSM12 directly binds to CTNNB1(also known asβ-Catenin)and regulates its protein stability to affect the CTTNB1-LEF1-TCF1 transcriptional complex formation and the associated WNT downstream signaling pathway.LSM12 depletion in CRC cells decreased the in vivo tumor growth through repression of cancer cell growth and acceleration of cancer cell apoptosis.Taken together,we suggest that the high expression of LSM12 is a novel factor leading to aberrant WNT signaling activation,and that strategies targeting this molecular mechanism may contribute to developing a new therapeutic method for CRC. | YAN ZHUANG CHUNLAN NING PENGFEI LIU YANPENG ZHAO YUE LI ZHENCHI MA LULING SHAN YINGZHE PIAO PENG ZHAO XUN JIN | 2022 | Oncology Research2022，30，6： | 0 |
| 7 | Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma显示文摘Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of cancer.However,conventional cell-SELEX technologies for aptamer discovery are time-consuming and laborious.Here we discovered a new aptamer BC-3 by using an improved rapid X-Aptamer selection process for human bladder carcinoma,for which there is no specific molecular probe yet.We show that BC-3 exhibited excellent affinity in bladder cancer cells but not normal cells.We demonstrate that BC-3 displayed high selectivity for tumor cells over their normal counterparts in vitro,in mice,and in patient tumor tissue specimens.Further endocytosis pathway analysis revealed that BC-3 internalized into bladder cancer cells via clathrin-mediated endocytosis.Importantly,we identified ribosomal protein S7(RPS7)as the binding target of BC-3 via an integrated methodology(mass spectrometry,colocalization assay,and immunoblotting).Together,we report that a novel aptamer BC-3 is discovered for bladder cancer and its properties in the disease are unearthed.Our findings will facilitate the discovery of novel diagnostic and therapeutic strategies for bladder cancer. | Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu Yi Xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu | 2023 | Genes & Diseases2023，10，5： | 0 |
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