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| 1 | 预后因素研究中常见的统计错误--偏倚显示文摘预后因素是患者诊治中非常重要的内容,大多数肿瘤患者的治疗决策取决于各种危险因素的存在与否。最突出的例子就是TNM(即肿瘤,淋巴结,远处转移)分期,但很多疾病都不能简单通过分期一个指标解决所有问题,而是要具体分析每个患者的综合预后因素。目前在判断胸腺瘤预后的临床研究中,一个主要的困难是缺乏实践指南,以至于到底哪些是预后因素尚不明确。本文叙述了临床实践中的一些问题并指出了临床研究中存在的各种偏倚,并试图提供解决方案,其中有许多方面在其它文献中作了详细讨论,但忽视了偏倚的存在。 | 付浩 中国胸腺瘤协作组全体成员 Mithat G?nen | 2014 | 中国肺癌杂志2014，17，2： | 2 |
| 2 | Liver Resection for Metastatic Colorectal Cancer in Patients with Concurrent Extrahepatic Disease: Results in 127 Patients Treated at a Single Center显示文摘 | Darren R. Carpizo PhD Chandrakanth Are MD William Jarnagin MD Ronald DeMatteo MD Yuman Fong MD Mithat G?nen PhD Leslie Blumgart MD Michael D'Angelica MD | 2009 | Annals of Surgical Oncology2009，，8： | 2 |
| 3 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 4 | Liver Planning Software Accurately Predicts Postoperative Liver Volume and Measures Early Regeneration显示文摘 | Amber L. Simpson David A. Geller Alan W. Hemming William R. Jarnagin Logan W. Clements Michael I. D’Angelica Prashanth Dumpuri Mithat G?nen Ivan Zendejas Michael I. Miga James D. Stefansic | 2014 | Journal of the American College of Surgeons2014，，： | 2 |
| 5 | A Selective Approach to the Resection of Cystic Lesions of the Pancreas显示文摘 | Peter JA Michael D Mithat G | 2006 | Ann Surg2006，244，4： | 1 |
| 6 | Prognostic Significance of Pathologic Nodal Status in Patients with Resected Pancreatic Cancer显示文摘 | Michael G. House Mithat G?nen William R. Jarnagin Michael D'Angelica Ronald P. DeMatteo Yuman Fong Murray F. Brennan Peter J. Allen | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 7 | Comparison of hepatocellular carcinoma in American and Asian patients by tissue array analysis显示文摘 | Tae‐Jin Song Yuman Fong Sung‐Jin Cho Mithat G?nen Michael Hezel Scott Tuorto Sang‐Yong Choi Young‐Chul Kim Sung‐Ock Suh Bum‐Hwan Koo Yang‐Seok Chae William R. Jarnagin David S. Klimstra | 2012 | J. Surg. Oncol2012，，1： | 1 |
| 8 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 9 | Distally-based neurofasciocutan eous flaps in electrical bums显示文摘 | Serkan Y Mithat A Kaan G | 2002 | Bums2002，28，： | 1 |
| 10 | Combination of different techniques for the treatment of earlobe keloids显示文摘 | Tayfun A Kaan G Mithat A | 2002 | Aesth Plast Surg2002，26，： | 1 |
| 11 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 12 | A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients显示文摘 | Peter JA Michael D Mithat G | 2006 | Ann Surg2006，244，4： | 1 |
| 13 | Detailed Pathologic Characteristics of the Primary Colorectal Tumor Independently Predict Outcome after Hepatectomy for Metastases显示文摘 | Kenneth Cardona Pedro Mastrodomenico Francesco D'Amico Jinru Shia Mithat G?nen Martin R. Weiser Philip B. Paty T. Peter Kingham Peter J. Allen Ronald P. Matteo Yuman Fong William R. Jarnagin Michael I. D'Angelica | 2013 | Annals of Surgical Oncology2013，，1： | 1 |
| 14 | Improving the clinical risk score: An analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases显示文摘 | Shishir K. Maithel Mithat G?nen Hiromichi Ito Ronald P. DeMatteo Peter J. Allen Yuman Fong Leslie H. Blumgart William R. Jarnagin Michael I. D'Angelica | 2012 | Surgery2012，，2： | 1 |
| 15 | Combination of different techaiques for the treatment of earlobe keioids显示文摘 | Tayfun A Kaan G Mithat A | 2002 | Aesth Plast Surg2002，26，： | 1 |
| 16 | Pasireotide for postoperative pancreatic fistula显示文摘 | Peter JA Mithat G Murray F | 2014 | N Engl J Med2014，370，21： | 1 |
| 17 | Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution显示文摘 | Michael G. House Hiromichi Ito Mithat G?nen Yuman Fong Peter J. Allen Ronald P. DeMatteo Murray F. Brennan Leslie H. Blumgart William R. Jarnagin Michael I. D'Angelica | 2010 | Journal of the American College of Surgeons2010，，5： | 1 |
| 18 | Remnant Growth Rate after Portal Vein Embolization Is a Good Early Predictor of Post-Hepatectomy Liver Failure显示文摘 | Universe Leung Amber L. Simpson Raphael LC. Araujo Mithat G?nen Conor McAuliffe Michael I. Miga E Patricia Parada Peter J. Allen Michael I. D’Angelica T Peter Kingham Ronald P. DeMatteo Yuman Fong William R. Jarnagin | 2014 | Journal of the American College of Surgeons2014，，： | 1 |
| 19 | Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases显示文摘Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic disease.Methods:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative staging.Results:The 125 planned subjects were enrolled.Findings seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%specific.For the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in any.Overall,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or CTAP.In particular,small(<1 cm)liver tumors were particularly poorly detected by FDG-PET.The area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no imaging.Conclusions:FDG-PET is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of patients.The high yield is due mainly to detection of extrahepatic disease.It is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic disease.It is not a good test for identification of small tumors in the liver. | Tim Akhurst Mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 1 |
| 20 | A Nomogram for Predicting Disease-specific Survival After Hepatic Resection for Metastatic Colorectal Cancer显示文摘 | Michael W. Kattan Mithat G?nen William R. Jarnagin Ronald DeMatteo Michael D?Angelica Martin Weiser Leslie H. Blumgart Yuman Fong | 2008 | Annals of Surgery2008，，2： | 1 |
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