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| 1 | Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer显示文摘BACKGROUND The connection between inflammatory bowel disease(IBD)and colorectal cancer(CRC)is well-established,as persistent intestinal inflammation plays a substantial role in both disorders.Cytokines may further influence the inflammation and the carcinogenesis process.AIM To compare cytokine patterns of active IBD patients with early and advanced CRC.METHODS Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior,in colon specimens,as mRNA biomarkers,and their serum protein levels.RESULTS We found a significant difference between higher gene expression of FoxP3,TGFb1,IL-10,and IL-23,and approximately equal level of IL-6 in CRC patients in comparison with IBD patients.After stratification of CRC patients,we found a significant difference in FoxP3,IL-10,IL-23,and IL-17A mRNA in early cases compared to IBD,and IL-23 alone in advanced CRC.The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients.CONCLUSION Our findings showed that IL-6 upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes(TGFb1,IL-10,IL-23,and transcription factor FoxP3)is a crucial primarily for CRC development.The significantly upregulated IL-6 could be a potential drug target for IBD and prevention of CRC development as well. | Tsvetelina Veselinova Velikova Lyuba Miteva Noyko Stanilov Zoya Spassova Spaska Angelova Stanilova | 2020 | World Journal of Gastroenterology2020，26，16： | 10 |
| 2 | Control of color and efficiency of light-emitting diodes based on polyfluorenes blended with hole-transporting molecules显示文摘 | Sainova D Miteva T Nothofer H G | 2000 | Appl Phys Lett2000，76，14： | 1 |
| 3 | Histopathologic analysis of dermal lymphatic alterations in chronic venous insufficiency ulcers using D2-40显示文摘 | Fernandez AP Miteva M Roberts B | 2011 | J Am Acad Dermatol2011，64，6： | 1 |
| 4 | Characterization of a bacterioein produced by Streptococcus thermophilus 81显示文摘 | Ivanova I Miteva V Stefanova TS | | 0，，： | 1 |
| 5 | Heat shock protein HSP70B as a marker for genotype resistance to environmental stress in chlorella species from contrasting habi- tats显示文摘 | CHANKOVA S MITROVSKA Z MITEVA D | 2013 | Gene2013，516，1： | 1 |
| 6 | Phylogenetic and physiological diversity of microorganisms isolated from a deep Greenland glacier ice core显示文摘 | Miteva V I Scheridant P P Brenchley JE | 2004 | Applied and Enviromental Microbiology2004，70，1： | 1 |
| 7 | Correlation between TNF-alpha and IL-12p40-containing cytokines in silicosis 显示文摘 | SLAVOV E MITEVA L PRAKOVA G | 2010 | Toxicol Ind Health2010，26，8： | 1 |
| 8 | Spitz nevus and atypical spitzoid neo-plasm显示文摘 | Miteva M Lazova R | 2012 | Semin Cutan Med Surg2012，29，3： | 1 |
| 9 | Improving the performance of polyfluorene-based organic light-emitting diodes via end-capping显示文摘 | Miteva T Meisel A Knoll W | 2001 | Adv Mater2001，13，8： | 1 |
| 10 | Interleukin-12B-3' UTR polymorphism in association with IL-12p40 and IL-12p70 serum levels and silicosis severity显示文摘 | STANILOVA S MITEVA L PRAKOVA G | 2007 | Int J Immunoganet2007，34，3： | 1 |
| 11 | Mesenchymal stem cells improve murine acute Coxsackievurs B3-induced myocarditis显示文摘 | VAN LINTHOUT S SAVVATIS K MITEVA K | | 0，，17： | 1 |
| 12 | 'Alternately Divided' epidermal nevus of the fingers显示文摘 | Torchia D Vega J Miteva M | | 0，，03： | 1 |
| 13 | Linear atrophoderma of Moulin显示文摘 | Miteva L Nikolova K Obreshkova E | 2005 | Int J Dermatol2005，44，10： | 1 |
| 14 | 查看详情显示文摘 | Miteva T Meisel A Knoll W Nothofer H.G Scherf U Muller D.C Meerholz K Yasuda K Neher D | | 0，，： | 1 |
| 15 | Diversity and ecology of psychrophilic microorganisms显示文摘 | Margesin R Miteva V | | 0，，03： | 1 |
| 16 | Design of protein membrane interaction inhibitors by virtual ligand screening,proof of concept with the C2 domain of factor Ⅴ显示文摘 | Segers K Sperandio O Sack M Fischer R Miteva M A Rosing J Nicolaes G A Villoutreix B O | | 0，，： | 1 |
| 17 | An unusual manifestation of linear atrophoderma of Moulin显示文摘 | Miteva L Obreshkova E | 2002 | Acta Derm Venereol2002，82，6： | 1 |
| 18 | Phylogenetic andphysiological diversity of microorganisms isolated from a deepGreenland glacier ice core显示文摘 | Miteva VI Sheridan PP Brenchly JE | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 19 | Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar显示文摘 | Tsviatko Alexandrov Dimitar Stefanov Pencho Kamenov Alexandra Miteva Sergei Khomenko Keith Sumption Hinrich Meyer-Gerbaulet Klaus Depner | 2013 | Veterinary Microbiology (-)2013，，1： | 1 |
| 20 | Sensory aroma andtaste profiles of raw-dried sausages manufactured with a li-polytically active yeast culture 显示文摘 | Miteva E Kirova E Gadjeva D | 1986 | Nahrung1986，30，8： | 1 |
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