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| 1 | Remarkably improved hydrogen storage properties of nanocrystalline TiO2-modified NaAlH4 and evolution of Ti- containing species during dehydrogenation/hydrogenation显示文摘增加 nanocrystalline TiO 的小数量<潜水艇class=“ a-plus-plus ”> 2 @C ( TiO <潜水艇class=“ a-plus-plus ”>在 nanoporous 碳上支持的 2 )合成戏剧性地减少操作温度并且在 NaAlH 为氢存储改进反应动力学<潜水艇class=“ a-plus-plus ”> 4 。nanocrystalline TiO < 潜水艇 class= “ a-plus-plus ” > 2 @C 合成在 900 AVO 八面体综合了是盖住试剂和生长的赞成过度饱和的选择吸附的结果种。随后, 3D 多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体被 AVO 八面体的简单 thermolysis 经由一个锻烧处理获得。作为为锂电池的阴极材料,多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体阴极在西班牙的北方展出 96 mAsga 盆的一个能力;并且(3 ) Zpy (n ?=? 17 ) , LV 质量从 226 被减少[178;306 ] g 到 220 [169;254 ] g (p ?=? 0.007 ) 在 13 点 ? 桴 ? 畦摮浡湥慴? 牦煥敵据敩 ? 景琠敨猠摥浩湥獴? 敢楳敤琠敨氠湯楧畴楤慮? 湡 ? 牴湡癳牥敳映湵慤敭瑮污映敲畱湥楣獥漠 ? 慥档戠極摬湩 ? 慢敳 ? 湯琠敨愠灭楬畴敤猠数瑣慲愠摮琠敨映潬牯猠数瑣慲? 慲楴?? 剓? 敭桴摯? | Xin Zhang Yongfeng Liu Ke Wang Mingxia Gao Hongge Pan | 2015 | Nano Research2015，8，2： | 8 |
| 2 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 3 | Longitudinal study of a community hospital integrated model for diabetes management in the Beijing Jingsong community显示文摘Objective:To determine the effects of a community hospital integrated model on the longitu-dinal management of diabetic patients.Methods:Four hundred forty-one patients with type 2 diabetes residing in Jingsong Commu-nity were randomly assigned to intensive and standard groups.Metabolic parameters were meas-ured in the two groups at baseline and after 36 months of management to compare the rate of goal achievement.Results:After comprehensive management,the overall control rate in the intensive group was increased from 2.7%to 9.6%compared with 2.3%-4.5%in the standard group.Specifically,the control rates for fasting plasma glucose,glycosylated hemoglobin,and blood pressure in the intensive group were significantly increased from 54.1%,40.0%,and 68.2%to 85.5%,74.6%,and 89.1%,respectively.The control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of treatment.Conclusion:The community hospital integrated model for longitudinal management effec-tively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes. | Jiandong Zhang Ning Zhuang Mingxia Yuan Lijuan Gao Chuan Bian Huaining Chen Qing Chi Suqing Hui Guiying Li Yanli Su Hongsong Bao Gang Wan Guangran Yang Shenyuan Yuan | 2014 | Family Medicine and Community Health2014，2，1： | 7 |
| 4 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 5 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy. | Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 5 |
| 6 | Blocking of the PD-1/PD-L1 interaction by a novel cyclic peptide inhibitor for cancer immunotherapy显示文摘The interaction of PD-1/PD-L1 allows tumor cells to escape from immune surveillance.Clinical success of the antibody drugs has proven that blockade of PD-1/PD-L1 pathway is a promising strategy for cancer immunotherapy.Here,we developed a cyclic peptide C8 by using Ph.D.-C7 C phage display technology.C8 showed high binding affinity with h PD-1 and could effectively interfere the interaction of PD-1/PD-L1.Furthermore,C8 could stimulate CD8^(+)T cell activation in human peripheral blood mononuclear cells(PBMCs).We also observed that C8 could suppress tumor growth in CT26 and B16-OVA,as well as anti-PD-1 antibody resistant B16 mouse model.CD8^(+)T cells infiltration significantly increased in tumor microenvironment,and IFN-γsecretion by CD8^(+)T cells in draining lymph nodes also increased.Simultaneously,we exploited T cells depletion models and confirmed that C8 exerted anti-tumor effects via activating CD8^(+)T cells dependent manner.The interaction model of C8 with h PD-1 was simulated and confirmed by alanine scanning.In conclusion,C8 shows anti-tumor capability by blockade of PD-1/PD-L1 interaction,and C8 may provide an alternative candidate for cancer immunotherapy. | Wenjie Zhai Xiuman Zhou Mingxia Zhai Wanqiong Li Yunhui Ran Yixuan Sun Jiangfeng Du Wenshan Zhao Lingxiao Xing Yuanming Qi Yanfeng Gao | 2021 | Science China(Life Sciences)2021，64，4： | 5 |
| 7 | Highly active multivalent multielement catalysts derived from hierarchical porous TiNb_(2)O_(7) nanospheres for the reversible hydrogen storage of MgH_(2)显示文摘Critical limitations in applying MgH_(2) as a hydrogen-storage medium include the high H_(2) desorption temperature and slow reaction kinetics.In this study,we synthesized hierarchical porous TiNb_(2)O_(7) spheres in micrometer scale built with 20-50 nm nanospheres,which showed stable activity to catalyze hydrogen storage in MgH_(2) as precursors.The addition of 7 wt.%TiNb_(2)O_(7) in MgH_(2) reduced the dehydrogenation onset temperature from 300 to 177℃.At 250℃,approximately 5.5 wt.%H_(2) was rapidly released in 10 min.Hydrogen uptake was detected even at room temperature under 50 bar hydrogen;4.5 wt.%H_(2) was absorbed in 3 min at 150℃,exhibiting a superior low-temperature hydrogenation performance.Moreover,nearly constant capacity was observed from the second cycle onward,demonstrating stable cyclability.During the ball milling and initial de/hydrogenation process,the high-valent Ti and Nb of TiNb_(2)O_(7) were reduced to the lower-valent species or even zero-valent metal,which in situ created multivalent multielement catalytic surroundings.A strong synergistic effect was obtained for hybrid oxides of Nb and Ti by density functional theory(DFT)calculations,which largely weakens the Mg-H bonding and results in a large reduction in kinetic barriers for hydrogen storage reactions of MgH_(2).Our findings may guide the further design and development of high-performance complex catalysts for the reversible hydrogen storage of hydrides. | Lingchao Zhang Ke Wang Yongfeng Liu Xin Zhang Jianjiang Hu Mingxia Gao Hongge Pan | 2021 | Nano Research2021，14，1： | 2 |
| 8 | A facile synthesis of Fe 3 O 4 /C composite with high cycle stability as anode material for lithium-ion batteries显示文摘 | Peng Wang Mingxia Gao Hongge Pan Jialei Zhang Chu Liang Junhua Wang Pei Zhou Yongfeng Liu | 2013 | Journal of Power Sources2013，，： | 2 |
| 9 | 显示文摘 | Pan Hongge Jin Qinwei Gao Mingxia | 2004 | J AUoys and Compd2004，373，： | 1 |
| 10 | 显示文摘 | Lin Yan Gao Mingxia Li Yufeng | 2008 | The chinese Journal of Nonferrous Metals2008，18，3： | 1 |
| 11 | Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer显示文摘 | Wei Liu Mingxia Zhai Zongyin Wu Yuanming Qi Yahong Wu Chao Dai Meng Sun Lu Li Yanfeng Gao | 2012 | Amino Acids2012，，： | 1 |
| 12 | A facile synthesis of Fe304/C composite with high cycle stability as anode material for lithium-ion batteries显示文摘 | Peng Wang Mingxia Gao Hongge Pan | 2013 | Journal of Power Sources2013，239，： | 1 |
| 13 | Influence of annealing treatment on Laves phase compound containing a V-based BCC solid solution phase-Part II:Electrochemical properties显示文摘 | Zhu Yunfeng Pan Hongge Gao Mingxia Liu Yongfeng Wang Qidong | 2003 | International Journal of Hydrogen Energy2003，28，： | 1 |
| 14 | High performance amorphous-Si@SiO x /C composite anode materials for Li-ion batteries derived from ball-milling and in situ carbonization显示文摘 | Dingsheng Wang Mingxia Gao Hongge Pan Junhua Wang Yongfeng Liu | 2014 | Journal of Power Sources2014，，： | 1 |
| 15 | High performance amorphous-Si@SiO x /C composite anode materials for Li-ion batteries derived from ball-milling and in situ carbonization显示文摘 | Dingsheng Wang Mingxia Gao Hongge Pan Junhua Wang Yongfeng Liu | 2014 | Journal of Power Sources2014，，： | 1 |
| 16 | 显示文摘 | Pan Hongge Liu Yongfeng Gao Mingxia | 2003 | International Journal of Hydrogen Energy2003，28，1： | 1 |
| 17 | Effects of Cr on the structural and electrochemical properties of TiV-based two-phase hydrogen storage alloys 显示文摘 | Hongge Pan Rui Li Mingxia Gao | 2005 | Journal of Alloys and Compounds2005，，： | 1 |
| 18 | 显示文摘 | Pan Hongge Liu Yongfeng Gao Mingxia | 2003 | International Journal of Hydrogen Energy2003，28，11： | 1 |
| 19 | 显示文摘 | Pan Hongge Liu Yongfeng Gao Mingxia | 2003 | J Alloys and Comp2003，351，： | 1 |
| 20 | Rare earth–Mg–Ni-based hydrogen storage alloys as negative electrode materials for Ni/MH batteries显示文摘 | Yongfeng Liu Yanhui Cao Li Huang Mingxia Gao Hongge Pan | 2010 | Journal of Alloys and Compounds2010，，3： | 1 |
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