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| 1 | Myeloid Cell?Specific ABCA1 Deletion Protects Mice From Bacterial Infection显示文摘 | Xuewei Zhu Marlena M. Westcott Xin Bi Mingxia Liu Kymberly M. Gowdy Jeongmin Seo Qiang Cao Abraham K. Gebre Michael B. Fessler Elizabeth M. Hitbold John S. Parks | 2012 | Circulation Research2012，，11： | 1 |
| 2 | Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases显示文摘Ferroptosis is defined as an iron-dependent,non-apoptotic cell death pathway,with specific morphological phenotypes and biochemical changes.There is a growing realization that ferroptosis has significant implications for several neurodegenerative diseases.Even though ferroptosis is different from other forms of programmed death such as apoptosis and autophagic death,they involve a number of common protein molecules.This review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis,apoptosis,and autophagy that are implicated in neurodegenerative diseases.We hope that this information provides new ideas for understanding the mechanisms and searching for potential therapeutic approaches and prevention of neurodegenerative diseases. | Xiaoting Dang Xuejie Huan Xixun Du Xi Chen Mingxia Bi Chunling Yan Qian Jiao Hong Jiang | 2022 | Neuroscience Bulletin2022，38，8： | 1 |
| 3 | Behavior of Phrynocephalus frontalis to Avoid Traps显示文摘Previous studies have shown that reptiles are capable of spatial learning and learn to locate important environmental resources so that they can return to those locations at a future time,when needed.Lizards improve their adaptability and survival by learning the position of their shelter in a complex environment.This behavior raises the question,whether lizards can sense danger,such as a trap,in their surroundings,by determining the location of the trap and avoiding it.In the present study,we used a pitfall trap to test if steppe toad-headed agama,Phrynocephalus frontalis,can learn to recognize the position of the trap and avoid it.Our results revealed that the percentage of activity time in the trap area was significantly reduced(P < 0.001) and the time of drop trap was also significantly reduced(P = 0.00631).The number of burrows dug by lizards distributed in the trap area was the least.Reduced activity time in the trap area was observed to have no obvious relationship with the drop in the number of burrows.The present study,therefore,demonstrates that P.frontalis are capable of learning the avoidance of a trap by locating its position.The findings offer significant insight in the understanding of reptilian behavior,which is important in the study of the role of reptiles in global ecology,especially because they are often very sensitive to environmental changes. | Mingxia FU Shaoyong CHEN Zhichao HE Zhiliang JIE Junhuai BI | 2017 | Asian Herpetological Research2017，18，1： | 0 |
| 4 | The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice显示文摘Many studies have revealed that gut microbes modulate host metabolism.In this study,we characterized the therapeutic effects of a novel gut commensal Luoshenia tenuis against host metabolic disorders.First,by in silico analysis,we demonstrated that the L.tenuis was prevalent in the gut microbiomes of healthy humans but were depleted specifically in obesity cohorts.Further in vitro cultivation revealed that L.tenuis produced short chain fatty acids that were verified to modulate host metabolism and some other volatile metabolites to benefit hosts by anti-inflammation and anti-tumor.Second,gavage of the L.tenuis significantly decreased the body weight gain and food intake of high-fat diet-feeding C57BL/6J mice,which was in parallel with the changed expression level of genes related to satiety and feeding behavior.We then performed the gavage trial using diet induced obese mice,and it revealed that the administration of L.tenuis alleviated significantly the abnormal glucose and lipid metabolisms and reduced the inflammatory response.In summary,this study revealed a previously-unknown human gut commensal microbe that benefited host metabolism,and set the stage for the development of novel next-generation probiotic applicable for treatment of obesity and related metabolic disorders. | Yu Jiang Mengxuan Du Lisheng Xie Minzhi Jiang Yaokun Zhang Mingxia Bi Chang Liu Hongwei Liu Shuangjiang Liu | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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