| 1 | A new lignan and active compounds inhibiting NF-κB signaling pathway from Caulis Trachelospermi显示文摘A new dibenzylbutyrolactone lignan named matairesinol 4'-O-β-D-cellobioside(1),together with a known compound(7R,85)-dihydrodehydrodiconiferyl alcohol(2)was isolated from Caulis Trachelospermi.The extract of Caulis Trachelospermi,which was separated by 80% alcohol extraction and subsequent HP-20 macroporous resin column chromatography,and its main components trachelogenin(3),nortrachelogenin(4),matairesinol(5)showed moderate inhibiting activities on NF-κB signaling pathway induced by TNFα,with the IC_(50) values of 17.7μg/mL,17.9μM,49.4μM and 29.1μM,respectively. | Chencheng Zhu LingJing Nengjiang Yu Xuedong Yang Yimin Zhao | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 6 |
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