|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses显示文摘一个鸟起源的 H7N9 流行性感冒病毒的流行病最近出现在中国,感染 45 死于的 134 个病人。这是怀有 N9 serotype neuraminidase (NA ) 的一个流行性感冒病毒被知道了感染人的第一次。H7N9 病毒是分叉的并且至少二不同 NA 和红血球凝聚素() 分别地,被发现了从临床孤立。这些病毒的原型是 A/Anhui/1/2013 和 A/Shanghai/1/2013。当 A/Shanghai/1/2013 NA 有能授与 NA 禁止者 oseltamivir 抵抗的 R294K 替换,从这二个病毒的 NA 是不同的。Oseltamivir 迄今为止由于它的力量和高 bioavailability 是最通常使用的反流行性感冒药。在这研究,我们证明 R294K 替换用基于蛋白质、基于病毒的试金与极端 oseltamivir 抵抗(超过 100 000 褶层) 导致 multidrug 抵抗。为禁止者抵抗决定分子的基础,我们从 A/Anhui/1/2013 N9 (包含 R294 ) 和 A/Shanghai/1/2013 N9 (包含 K294 ) 解决了 NA 的高分辨率的水晶结构。在为 oseltamivir 绑定的相反的 E276 符合构造的 R294K 替换结果,并且因而禁止者羧化物相互作用的损失,它损害所有古典 NA ligands/inhibitors 的绑定。而且,我们与更低的病毒的健康一起在减少的 NA 催化效率发现那 R294K 替换结果。这帮助解释 K294 为什么主要在 oseltamivir 处理并且不在主导的人感染的病毒的选择压力下面在 H7N9 感染的临床的情况中被发现了。这暗示 oseltamivir 能高效地仍然在 H7N9 感染的处理被使用。 | YanWu #x0002A YuhaiBi #x0002A Christopher JVavricka #x0002A XiaomanSun YanfangZhang FengGao MinZhao HaixiaXiao ChengfengQin JianhuaHe WenjunLiu JinghuaYan JianxunQi George FGao | 2013 | Cell Research2013，，12： | 15 |
| 2 | Shell powder as a novel bio-filler for thermal insulation coatings显示文摘The feasibility of employing shell powder as a novel bio-filler to prepare fluorocarbon coating is demonstrated.According to the relevant Chinese standards, the thermal and mechanical properties of the shell powder-filled fluorocarbon coating were evaluated, and compared with those filled by commercial calcium carbonate. All the shell powder-filled coatings can meet the requirements stated in the relevant standards, and with decreasing the particle size of the shell powders, the performance of the thermal insulation coating is enhanced. The coating(SC3) filled by shell powders with an average particle size of 2.81 μm possesses a better thermal insulation performance than the coating(CC) filled by commercial calcium carbonate. The coating SC3 has comparable adhesive force and washing resistance with the coating CC, and in the washing resistance test, after 2000 cycles, the coating SC3 was still able to cover totally their substrates. This work demonstrates a high value-added disposal method for the aquacultural wastes. | Peigen Zhang Jingwen Tang Qiang Tang Minzhao Zhang Luwei Shen Wubian Tian Yamei Zhang Zhengming Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 3 | Genetic divergence among geographical populations of the migratory locust in China显示文摘The random amplified polymorphic DNA (RAPD) technique was used to examine genetic divergence and interrelations of 11 geographical populations of the migratory locust in China, and the role of spatial separation in the population differentiations. AMOVA analysis of genetic variations in all the populations indicated greater within- (79.55%) than among-population variability (20.45%), and that there were significant differentiations among the populations; 11 populations were divided into four regional groups, with significantly greater variability within (82.99%) than among the groups (17.01%), and there existed apparent regional differentiations. Paired comparisons showed significantly greater variability within- than between-groups, indi-cating significant differentiations between populations of different regional groups. Of all the pairwise comparisons, Hainan and Tibetan groups displayed the greatest differentiation, with the difference between the two groups being seven folds of that between populations within the groups; the least differentiations were exhibited between the groups of Hainan, Xinjiang, and Inner Mongolia, with the differences between groups being only half of the differences between populations within the groups. Mantel tests of the genetic and spatial distances showed that the two matrices were significantly correlated (p<0.01), indicating that the geographical isolation played an important role in the differentiations of the geographical populations of the migratory locusts. Cluster analysis divided all populations into four major groups: Xinjiang and Inner Mon-golia group, the Great Plains of North China (the Yellow River and Huai River Plains) group, Hainan group, and Tibet group. Principal component analysis (PCA) supported the division of populations based on the cluster analysis. However, analysis of individuals clustered the locusts into five populations: Xinjiang and Inner Mongolia, Hami in Xinjiang, the Great Plains of North China, Hainan, and Tibet. The locust populations in eastern China displayed apparently conti-nous and gradient variations; as such authors consider that there were no necessity and valid reasons for further division of subspecies. The subspecific status for the main geographical populations of the migratory locusts in China was discussed. | ZHANG Minzhao KANG Le | 2005 | Science China(Life Sciences)2005，48，6： | 2 |
| 4 | Nanocolorants: A novel class of colorants, the preparation and performance characterization显示文摘 | Zhenkun Hu Minzhao Xue Qing Zhang Qiaorong Sheng Yangang Liu | 2006 | Dyes and Pigments2006，，1： | 1 |
| 5 | Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor显示文摘The dense desmoplastic stroma and immunosuppressive microenvironment of pancreatic cancer hinder the penetration of drugs and induce a considerable resistance to conventional chemoradiotherapy. Although nanomedicine has recently shown attractive potential in cancer immunotherapy, it remains a great challenge to achieve efficient drug delivery and potent immune activation.Here, a stimuli-responsive nanosystem, comprising superparamagnetic iron oxide nanocrystals and nitric oxide(NO) donors,was developed for in-situ triggered catalytic cascade reaction to produce abundant free radicals and remodel the anti-tumor immunity. The nanosystem was activated in the tumor microenvironment to produce NO which dilated the tumor vasculature for efficient drug delivery, and the iron oxide nanocrystals catalyzed the reaction of NO to generate reactive oxygen-nitrogen species(RONS) with high cytotoxicity. Moreover, owing to the catalytic cascade reactions mediated by the nanosystem, the tumor associated macrophages(TAMs) were converted to a proinflammatory M1 phenotype and tumor infiltration of effector T cells was promoted to result in potent anti-tumor immunotherapy which could be readily monitored with magnetic resonance imaging(MRI). | Gengjia Chen Yujun Cai Bo Li Minzhao Lin Xiaobin Wang Zhiyong Wang Xintao Shuai | 2022 | Science China Chemistry2022，65，7： | 1 |
| 6 | Determination of sulfite in beer samples using an amperometricfill and flow channel biosensor employing sulfite oxidase显示文摘 | MinZhao BrynnHibbertD JustinGoodingJ | 2006 | Analytica Chimica Acta2006，556，： | 1 |
| 7 | Solution-processed multi-resonance organic light-emitting diodes with high efficiency and narrowband emission显示文摘With excellent color purity(full-width half maximum(FWHM)<40 nm)and high quantum yield,multiresonance(MR)molecules can harvest both singlet and triplet excitons for highly efficient narrowband organic light-emitting diodes(OLEDs)owing to their thermally activated delayed fluorescence(TADF)nature.However,the highly rigid molecular skeleton with the oppositely positioned bo ron and nitrogen in generating MR effects results in the intrinsic difficulties in the solution-processing of MR-OLEDs.Here,we demonstrate a facile strategy to increase the solubility,enhance the efficiencies and modulate emission color of MR-TADF molecules by extending aromatic rings and introducing tert-butyls into the MR backbone.Two MR-TADF emitters with smaller singlet-triplet splitting energies(ΔE~(ST))and larger oscillator strengths were prepared conveniently,and the solution-processed MR-OLEDs were fabricated for the first time,exhibiting efficient bluish-green electroluminescence with narrow FWHM of 32 nm and external quantum efficiency of 16.3%,which are even comparable to the state-of-the-art performances of the vacuum-evaporated devices.These results prove the feasibility of designing efficient solutionprocessible MR molecules,offering important clues in developing high-performance solution-processed MR-OLEDs with high efficiency and color purity. | Shen Xu Qingqing Yang Ying Zhang Hui Li Qin Xue Guohua Xie Minzhao Gu Jibiao Jin Ling Huang Runfeng Chen | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 8 | Dissolution of copper phthalocyanine and fabrication of its nano-structure film显示文摘The mono-protonated and di-protonated forms of copper phthalocyanine (CuPc) were obtained by increasing concentrations of trifluoroacetic acid (TFA) solution to a fixed concentration of CuPc solutions. UV-Vis spectrum shows that the Q bands of these two derivatives split and shift to the red, which means successive protonation happened and caused the two derivatives to lose their symmetry. After the protonation step, the solubility of protonated CuPc in organic solvent increased 60 times. The CuPc film was fabricated by the electrophoretic deposition (EPD) method from the protonated CuPc dissolved in nitromethane containing TFA. Scanning electron microscopy (SEM) showed that the deposited CuPc film on the indium tin oxide (ITO) substrate is composed of thread-like nanobelts with diameters between 100 nm and 200 nm. Furthermore, the CuPc film is in α phase with stacking direction (b-axis) parallel to the substrate, which was detected by X-ray diffraction. | SU JinLi XUE MinZhao MA Ning SHENG QiaoRong ZHANG Qing LIU YanGang | 2009 | Science China Chemistry2009，52，7： | 1 |
| 9 | Nanocolorants : a novel class of colorants, the preparation and performance characterization显示文摘 | Hu Zhenkun Xue Minzhao Zhang Qing | 2008 | Dyes and Pigments2008，76，： | 1 |
| 10 | The effect of Mg precipitation on the mechanical properties of 5XXX aluminum alloys显示文摘 | Wei Wen Yu Minzhao Morris J G | 2005 | Materials Science & Engineering A2005，392，： | 1 |
| 11 | Nanocolorants: A novel class of colorants, the preparation and performance characterization显示文摘 | Zhenkun Hu Minzhao Xue Qing Zhang Qiaorong Sheng Yangang Liu | 2006 | Dyes and Pigments2006，，1： | 1 |
| 12 | Synthesis and Physical Properties of Benzopyridazine-Based Conjugated Molecules显示文摘作为捐赠电子的手臂作为撤退电子的核心和 thiophene 衍生物包括 2,3-benzopyridiazine 的一系列新奇器官的结合的分子(5a5d ) 在好收益成功地被综合了。紫外可见(紫外力) 5a5d 的吸收系列和荧光系列表明光性质被在氮和硫原子之间的相互作用强烈在 thiophene 戒指在烷基链的结合的脊梁,以及位置影响。试验性的结果和理论计算数据清楚地显示乐队差距和 LUMO 和人的精力层次能被烷基链的位置在 thiophene 戒指调整。因此,结合的分子的这个班的结构性质关联能很好被建立。 | Yuezeng Su Wei Xu Feng Qiu Dongqing Wu Ping Liu Minzhao Xue Fan Zhang | 2013 | Chinese Journal of Chemistry2013，31，11： | 1 |
| 13 | Handedness inversion of chiral mesoporous silica: A diffuse-reflectance circular dichroism study显示文摘Chiral mesoporous silica ribbons and rods with inversed handedness have been synthesized with the same enantio pure N-acylaminoacidat temperatures of 0℃and 20℃ respectively. With involving Cu^(2+)and meso-tetra(4-sulfonatophenyl)porphyrin(TPPS) as probes, ribbons and rods revealed opposite signals in diffuse-reflectance circular dichroism(DRCD) spectra, indicating the existence of inversed supramolecular chiral imprintings through helical stacking of amphiphiles. The structural evolution was systematically studied by the freeze-dried products sampled at different time after the addition of silica precursors. The H-bonding-depended molecular orientation probably controls the chiral sense upon forming chiral molecular stacking, which would be the origin of such handedness inversion | Nan Wang Ruiyu Lin Minzhao Xue Yingying Duan Shun'ai Che | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 14 | Preparation and characterization of perfluorosulfonic resin/titania hybrid transparent films显示文摘Preparation and characterization of perfluorosulfonic resin/titania organic-inorganic hybrid films were presented. The transparent hybrid films were prepared by hydrothermal treatment at low temperature of a mixed solution of tetrabutyl titanate and perfluorosulfonic resin with the help of acetylacetone. The characterization was carried out by SEM,XRD,FT-IR,UV-Vis and TGA. The results showed that the perfluorosulfonic resin/titania hybrid transparent films were composed of titania particles dispersed in the perfluorosulfonic resin matrix very well and the titania was of anatase phase. Its diameter de-creased with increasing weight ratio of titania to perfluorosulfonic resin. | LI JianMei XUE MinZhao ZHANG YongMing LIU YanGang | 2007 | Science China Chemistry2007，50，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员