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| 1 | Germafluorene conjugated copolymer——synthesis and applications in blue-light-emitting diodes and host materials显示文摘A germafluorene-fluorene copolymer was successfully obtained via Suzuki polymerization.The ger-manium containing copolymer has an efficient blue light emission under the ultraviolet irradiation and its single layer EL device showed the highest brightness of 2630 cd/m2 at 7.8 V and the highest effi-ciency of 0.301 lm/W at 6.2 V.The copolymer can also serve as the host material for phosphorescent metal complexes with the maximum brightness of 15600 cd/m2 and the quantum efficiency of 8.5%.The results are quite promising and promise that as its analogs of fluorene and silafluorene,germafluorene is an excellent building block for blue light-emitting polymers and host materials. | CHEN RunFeng ZHU Rui ZHENG Chao LIU ShuJuan FAN QuLi HUANG Wei | 2009 | Science China Chemistry2009，52，2： | 12 |
| 2 | Purely organic optoelectronic materials with ultralong-lived excited states under ambient conditions显示文摘The exponential growth of utilizing synthetic organic molecules in optoelectronic applications poses strong demands for rational control over the excited states of the materials. The manipulation of excited states through molecular design has led to the development of high-performance optoelectronic devices with tunable emission colors, high quantum efficiencies and efficient energy/charge transfer processes. Recently, a significant breakthrough in lifetime tuning of excited states has been made;the purely organic molecules were found to have ultralonglived excited state under ambient conditions with luminescence lifetimes up to 1.35 s, which are several orders of magnitude longer than those of conventional organic fluorophores. Given the conceptual advance in understanding the fundamental behavior of excited state tuning in organic luminescent materials, the investigations of organic ultralong room-temperature phosphorescence(OURTP) should provide new directions for researches and have profound impacts on many different disciplines. Here, we summarized the recent understandings on the excited state tuning, the reported OURTP molecules and their design considerations,the spectacular photophysical performance, and the amazing optoelectronic applications of the newly emerged organic optoelectronic materials that free of heavy metals. | Jie Yuan Yuting Tang Shen Xu Runfeng Chen Wei Huang | 2015 | Science Bulletin2015，60，19： | 4 |
| 3 | Two Symmetrically Bis-substituted Pyrene Derivatives: Synthesis, Photoluminescence, and Electroluminescence显示文摘二种 cyanophenyl 终止了分核衍生物因为器官的轻射出的二极管被 UV/Vis 综合并且描绘,荧光(FL ) , 1 H NMR, MALDI-TOF, CV 和 TGA。两混合物展出了蓝光致发光和高度荧光灯在答案的 85% 和 75% 的量产量。由于乙炔分隔符的存在,混合物由高共面区分自己,高热的稳定性,几乎别司烧处于从没有乙炔的混合物的稳固的状态是移动和清楚的 excimer 形成。以便压制分子的聚集, electroluminescent 性质被在 PVK 做材料学习。结果证明那精力转移从主人 PVK 发生了在材料身上。 | Xiaojie Gong Xiang Xie Naiwu Chen Chaoyue Zheng Jie Zhu Runfeng Chen Wei Huang Deqing Gao | 2015 | Chinese Journal of Chemistry2015，33，8： | 3 |
| 4 | Nitrogen-doped carbon nanotube/polyaniline composite:Synthesis, characterization, and its application to the detection of dopamine显示文摘Nitrogen-doped carbon nanotubes (N-CNTs)/polyaniline (PANI) composites are developed as an electrode material for biosensors. The morphology, composition, and optical properties of the resulting products were characterized by transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and ultraviolet-visible absorption spectra (UV-vis). Furthermore, N-CNTs/PANI composite was immobilized on the surface of a glassy carbon electrode (GCE) and applied to construct a sensor. The obtained N-CNTs/PANI-modified GCE showed one pair of redox peaks and high catalytic activity for the oxidation of dopamine (DA) in a neutral environment. Differential pulse voltam-mograms results illustrate that the fabricated DA biosensor has high anti-interference ability towards ascorbic acid (AA). In addition, the fabricated biosensor showed superior performances with two wide linear ranges from 1 to 80 μM and from 1.5 to 3.5 mM and a low detection limit of 0.01 μM. | FENG XiaoMiao LI RuiMei MA YanWen CHEN RunFeng MEI QunBo FAN QuLi HUANG Wei | 2011 | Science China Chemistry2011，54，10： | 3 |
| 5 | MOF-Like 3D Graphene-Based Catalytic Membrane Fabricated by One-Step Laser Scribing for Robust Water Purification and Green Energy Production显示文摘Increasing both clean water and green energy demands for survival and development are the grand challenges of our age.Here,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCM)with active metal nanoparticles(AMNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing technology.The as-prepared 3D-GCM shows high porosity and uniform distribution with AMNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AMNs in 3D-GCM actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane separation.Most importantly,the 3D-GCM with the welding of laser scribing overcomes the lateral shear force damaging during the long-term separation.Moreover,the 3D-GCM could emit plentiful of hot electrons from AMNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy generation.This“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCM microreactor in the tricky wastewater purification and sustainable clean energy production as well. | Xinyu Huang Liheng Li Shuaifei Zhao Lei Tong Zheng Li Zhuiri Peng Runfeng Lin Li Zhou Chang Peng Kan-Hao Xue Lijuan Chen Gary J.Cheng Zhu Xiong Lei Ye | 2022 | Nano-Micro Letters2022，14，11： | 2 |
| 6 | Synthesis,characterization and applications of vinylsilafluorene copolymers:New host materials for electroluminescent devices显示文摘Vinylsilafluorene(VSiF) was successfully synthesized and copolymerized with vinylcarbazole and methyl methacrylate via free radical copolymerization for the first time.The synthesis,photophysical properties,computational modeling studies,and organic light-emitting devices of the VSiF copolymers were presented.The good coordinated photoluminescent(PL) spectra with the absorption of blue light-emitting materials and the high energy band-gap of the VSiF copolymers were observed.Higher triplet band gap(3Eg) to host the blue phosphorescent emitters and better HOMO and LUMO than PVK for electron and hole injection and transportation of the VSiF model compounds were revealed by density functional theory(DFT) calculations.The preliminary device results in applications of these copolymers as host materials for green phosphorescent emitters demonstrate the copolymers of VSiF and vinylcarbazole have comparable device performance of polyvinylcarazole(PVK),suggesting a bright future of VSiF as building blocks for host materials. | CHEN RunFeng,ZHU Rui,ZHENG Chao,FAN QuLi & HUANG Wei* Key Laboratory for Organic Electronics & Information Displays(KLOEID) Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications(NUPT),Nanjing 210046,China | 2010 | Science China Chemistry2010，53，11： | 2 |
| 7 | Near-Infrared-Excitable Organic Ultralong Phosphorescence through Multiphoton Absorption显示文摘Organic ultralong room-temperature phosphorescence(OURTP)with a long-lived triplet excited state up to several seconds has triggered widespread research interests,but most OURTP materials are excited by only ultraviolet(UV)or blue light owing to their unique stabilized triplet-and solid-state emission feature.Here,we demonstrate that near-infrared-(NIR-)excitable OURTP molecules can be rationally designed by implanting intra/intermolecular charge transfer(CT)characteristics into Haggregation to stimulate the efficient nonlinear multiphoton absorption(MPA).The resultant upconverted MPA-OURTP show ultralong lifetimes over 0.42 s and a phosphorescence quantum yield of~37%under both UV and NIR light irradiation.Empowered by the extraordinary MPA-OURTP,novel applications including two-photon bioimaging,visual laser power detection and excitation,and lifetime multiplexing encryption devices were successfully realized.These discoveries illustrate not only a delicate design map for the construction of NIR-excitable OURTP materials but also insightful guidance for exploring OURTP-based nonlinear optoelectronic properties and applications. | Ye Tao Lele Tang Qi Wei Jibiao Jin Wenbo Hu Runfeng Chen Qingqing Yang Huanhuan Li Ping Li Guichuan Xing Quli Fan Chao Zheng Wei Huang | 2020 | Research2020，，1： | 1 |
| 8 | Interfacial Assembly Directed Unique Mesoporous Architectures:From Symmetric to Asymmetric显示文摘CONSPECTUS:Functional mesoporous materials have experienced flourishing developments over the past 30 years,and they are now a big family including large variety of compositions and architectures.Due to large surface area,high pore volume,tunable pore size,and unique mesostructures,mesoporous nanomaterials have been widely used in catalysis,energy conversion and storage,drug delivery,etc.Out of the various methods of architecting mesoporous materials,the soft-templating method that allows regulating the architecture by tuning the assembly process,is used mostly for fabricating mesoporous materials.In soft templating methods,amphiphilic surfactants and precursors assemble into“soft”micelles,and micelles further assemble into mesoporous materials.Usually,micelles homogeneously nucleate and assemble into mesoporous nanomaterials.Such a homogeneous assembly process naturally leads to“routine”structures such as nanospheres or other symmetric architectures.Introduction of nanoparticles during the micelle assembly process results in conventional core@shell structures,which though combining the mesoporous shell and functional core,is still simple.Nowadays,growing demands in diverse applications urgently require mesoporous nanomaterials with novelty in mesostructures,compositions,surface properties,morphologies,functionalities,etc.Therefore,researchers have been seeking to gain better control of the micelles’assembly process,pursuing the synthesis of mesoporous nanomaterials with unique architectures,especially morphology,mesostructure,surface chemistry,etc.Recently,the effect of“interface”during micelles’assembly process has aroused great attention.The introduction of an interface into the reaction system turns the micelles’homogeneous assembly into a heterogeneous one,altering their assembly behavior and thus leading to mesoporous nanomaterials with unique architectures.By manipulation of the interfacial-assembly behavior of micelles,a series of mesoporous nanomaterials with unique architectures have been developed,with structures ranging from symmetric to asymmetric.In this Account,the recent progresses in interfacial-assembly-directed mesoporous nanomaterials with unique architectures,both the fabrication and applications are systematic reviewed.The architectures of the obtained mesoporous nanomaterials are categorized into symmetric and asymmetric,including virus-like,bouquet-like,multishell hollow structures,and also Janus,multipods,hemisphere structures,etc.We introduced how interfaces such as nanoparticle−surface,water−oil interface,macropore scaffold interfaces,etc.are utilized to direct the assembly of micelles.The methods of controlling micelles’interfacial-assembly behavior,such as biphasic assembly method,interfacial-energy method,interface tension method,and so on are highlighted.The applications of these unique mesoporous nanomaterials in fields of catalysis,energy conversion,and biomedicine are surveyed.At the end of the review,a brief summary of the field,as well as shortcomings,challenges,and perspectives of the field are also included. | Tiancong Zhao Liang Chen Runfeng Lin Pengfei Zhang Kun Lan Wei Zhang Xiaomin Li Dongyuan Zhao | 2020 | Accounts of Materials Research2020，1，1： | 1 |
| 9 | Solution-processed multi-resonance organic light-emitting diodes with high efficiency and narrowband emission显示文摘With excellent color purity(full-width half maximum(FWHM)<40 nm)and high quantum yield,multiresonance(MR)molecules can harvest both singlet and triplet excitons for highly efficient narrowband organic light-emitting diodes(OLEDs)owing to their thermally activated delayed fluorescence(TADF)nature.However,the highly rigid molecular skeleton with the oppositely positioned bo ron and nitrogen in generating MR effects results in the intrinsic difficulties in the solution-processing of MR-OLEDs.Here,we demonstrate a facile strategy to increase the solubility,enhance the efficiencies and modulate emission color of MR-TADF molecules by extending aromatic rings and introducing tert-butyls into the MR backbone.Two MR-TADF emitters with smaller singlet-triplet splitting energies(ΔE~(ST))and larger oscillator strengths were prepared conveniently,and the solution-processed MR-OLEDs were fabricated for the first time,exhibiting efficient bluish-green electroluminescence with narrow FWHM of 32 nm and external quantum efficiency of 16.3%,which are even comparable to the state-of-the-art performances of the vacuum-evaporated devices.These results prove the feasibility of designing efficient solutionprocessible MR molecules,offering important clues in developing high-performance solution-processed MR-OLEDs with high efficiency and color purity. | Shen Xu Qingqing Yang Ying Zhang Hui Li Qin Xue Guohua Xie Minzhao Gu Jibiao Jin Ling Huang Runfeng Chen | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 10 | A Theoretical Insight into the Mechanism of Cu(I)-Catalyzed C--N Coupling between Aryl Halides and Aqueous Ammonia显示文摘Cu (I) 的计算调查催化没有任何底的增加,在芳基卤化物和水的氨之间联合的 CN 或 ligand 被报导。密度功能的理论计算被执行为主要的芳香的胺的准备揭示 ligand 免费的胺化作用反应的机制。通过在答案的可能的 Cu 种类的相对集中的系统的评估,我们建议活跃催化剂是中立 Cu (I) 建筑群而非 Cu (I) 阳离子;芳基溴化物的氧化增加是催化周期的灵巧的步;反应物(NH 3) 和溶剂分子(NMP ) 能充当 Cu 种类的 ligands 帮助减少前面的反应的激活精力并且增加反向的反应的激活精力;除了小径 B, deprotonation 步由于极端发热的特征是不可逆的;H 2 O 运动地被赞成,当 HBr 的热力学地被比较喜欢时。这些调查结果应该为 ligand 免费的催化 Cu 的 CN 跨 coupling 反应的机制理解并且为高度有效的胺化作用催化剂系统的进一步的开发是珍贵的。 | Ting Chen Mingkuan Yan Chao Zheng Jie Yuan Shen Xu Runfeng Chen Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
| 11 | Synthesis, struc- ture, and optoelectronic properties of Phosphafluorene co- polymers 显示文摘 | Chen Runfeng Zhu Rui Fan Quli | 2008 | Organic Letters2008，10，13： | 1 |
| 12 | Conju- gated chelating polymers with charged iridium complexes in the backbones: Synthesis, characterization, energy trans fer, and electrochemical properties显示文摘 | Liu Shuiuan Zhao Qiang Chen Runfeng | 2006 | Chemistry A Euro- pean Journal2006，12，16： | 1 |
| 13 | Theoretical study of the electronic ground states and low-lying singlet excited states of thiophene-based spirofluorenes显示文摘The electronic structures and optical properties of oligothiophene substituted spirofluorenes are investigated theoretically with semi-empirical quantum chemical calculations. A theoretical investigation of the interaction between two perpendicular π-systems of various oligothiophene substituted spirofluorenes is conducted. The results demonstrate that the interaction between two perpendicular branches is reduced by oligothiophene substitutions. Photoexcitation induced relaxation is mainly located on one of the equivalent branches or the branch with longer conjugation length. In addition to these benefits brought by 9,9-spirobifluorene center, the specific oligothiophene moieties linked to the spiro center also have properties of significant merit, such as the ability to tune energy levels and emission colors by controlling the conjugation length. | CHEN RunFeng MA Cong PAN JingFang ZHENG Chao HUANG Wei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，5： | 1 |
| 14 | Theoretical investigation of substitution and end-group effects on poly(p-phenylene vinylene)s显示文摘Semi-empirical AM1 and ZINDO/S,as well as density function theory(DFT)method B3LYP/6-31G(d)quantum chemical calculations were carried out to study the electronic structures and optical properties of poly(p-phenylene vinylene)derivatives(PPVs)with 10 and 11 phenylene rings in the backbone.The calculations suggest that the assembly of alternate incorporation of CN and alkoxy substituted phenylene rings in the PPV backbone could be a good way to construct organic semiconductors with low HOMO/LUMO energy band-gaps.The effect of the end-group on the electronic structures and optical properties of the conjugated polymer was investigated by the calculated UV-Vis and UPS spectra.It was demonstrated that the aldehyde and phosphate end-groups have limited effects on the photophysical properties in the UV-Visible range. | ZHENG Chao PAN JingFang CHEN RunFeng WANG Yang HUANG Wei | 2014 | Science China Chemistry2014，57，3： | 0 |
| 15 | Accelerated prediction of Cu-based single-atom alloy catalysts for CO_(2) reduction by machine learning显示文摘Various strategies,including controls of morphology,oxidation state,defect,and doping,have been developed to improve the performance of Cu-based catalysts for CO_(2) reduction reaction(CO_(2)RR),generating a large amount of data.However,a unified understanding of underlying mechanism for further optimization is still lacking.In this work,combining first-principles calculations and machine learning(ML)techniques,we elucidate critical factors influencing the catalytic properties,taking Cu-based single atom alloys(SAAs)as examples.Our method relies on high-throughput calculations of 2669 CO adsorption configurations on 43 types of Cu-based SAAs with various surfaces.Extensive ML analyses reveal that low generalized coordination numbers and valence electron number are key features to determine catalytic performance.Applying our ML model with cross-group learning scheme,we demonstrate the model generalizes well between Cu-based SAAs with different alloying elements.Further,electronic structure calculations suggest surface negative center could enhance CO adsorption by back donating electrons to antibonding orbitals of CO.Finally,several SAAs,including PCu,AgCu,GaCu,ZnCu,SnCu,GeCu,InCu,and SiCu,are identified as promising CO_(2)RR catalysts.Our work provides a paradigm for the rational design and fast screening of SAAs for various electrocatalytic reactions. | Dashuai Wang Runfeng Cao Shaogang Hao Chen Liang Guangyong Chen Pengfei Chen Yang Li Xiaolong Zou | 2023 | Green Energy & Environment2023，8，3： | 0 |
| 16 | Resonance hosts for high efficiency solution-processed blue and white electrophosphorescent devices显示文摘The exploration of high-performance solution-processible host materials for blue and white electrophosphorescent devices is a key and fundamental challenge in the ongoing development of organic semiconductors.Herein,two solution-processible resonance host materials with self-adaptive characteristics are delicately designed and constructed.Because of the dynamic tautomerization upon resonance variation,these smart hosts show self-adaptive and selectively enhanced charge carrier flux at high triplet energy levels.Conferred by the resonance molecules,solution-processed blue and white devices exhibit excellent maximum current efficiencies(CEs)of 29.8 and 57.3 cd A−1,and external quantum efficiencies(EQEs)up to 14.5%and 23.5%,respectively.Our works highlight the significant progress of the solution-processed phosphorescent organic light-emitting diodes(PhOLEDs)using resonance host molecules,potentially furnishing a leap forward in constructing advanced organic semiconductors for next-generation optoelectronic devices. | Huanhuan Li Jibiao Jin Yuan Xiang Ying Zhang Ye Tao Mingguang Li Qin Xue Guohua Xie Wei Huang Runfeng Chen | 2020 | Science China Chemistry2020，63，11： | 0 |
| 17 | Silafluorene moieties as promising building blocks for constructing wide-energy-gap host materials of blue phosphorescent organic light-emitting devices显示文摘In this article, we reported the synthesis and characterization of a novel silafluorene-based host material, 1,3-bis(5-methyl-5Hdibenzo[b,d]silol-5-yl)benzene(Me-DBSi B), for blue phosphorescent organic light-emitting devices(PHOLEDs). The MeDBSi B was constructed by linking 9-methyl-9-silafluorene units to the phenyl framework through the sp3-hybridized silica atom to maintain high singlet and triplet energy, as well as to enhance thermal and photo-stability. The calculated result shows that the phenyl core does not contribute to both the highest occupied molecular orbital and lowest unoccupied molecular orbital. Wide optical energy gap of 4.1 e V was achieved. When the Me-DBSi B was used as the host and iridium(III) bis[(4,6-difluorophenyl)pyridinato-N,C2′]picolate(Firpic) as the guest, a maximum current efficiency was 14.8 cd/A, lower than the counterpart of 1,3-bis(9-carbazolyl)benzene(28 cd/A). The unbalanced barrier for electron and hole injection to host layer may be responsible for low efficiency. Even so, our results show that silafluorene moieties are promising building blocks for constructing wide-energy-gap host materials. | Dongdong Wang Qingqing Liu Yue Yu Yong Wu Xinwen Zhang Hua Dong Lin Ma Guijiang Zhou Bo Jiao Zhaoxin Wu Runfeng Chen | 2015 | Science China Chemistry2015，58，6： | 0 |
| 18 | Predictive Maintenance of Manned Spacecraft Through Remaining Useful Life Estimation Technique显示文摘Manned spacecraft pose challenges in terms of extremely high safety and reliability, and with the growth of system complexity and longer on-orbit operation time, the traditional management mode, such as monitoring the threshold of parameter passively, is difficult to meet the required safety standards. Predictive maintenance, which analyzes the system heath trend and estimates remaining useful life(RUL) to establish maintenance strategies ahead of time before failure occurs, is a new mode to approach maintenance tasks. Here, a predictive maintenance strategy for complex manned spacecraft is proposed based on the remaining useful life estimation technique. Firstly, a health index is established based on an abundance of telemetry data, reflecting the system's current health state. Secondly, we map the health index to the remaining useful life through system degradation modelling, taking into consideration both the system's stochastic deterioration and uncertainty. The maintenance and management strategies are then made based on the calculated distribution of RUL time. Finally, a case study on Chinese space station energy system predictive maintenance is presented. | CHEN Runfeng YANG Hong | 2018 | Aerospace China2018，19，3： | 0 |
| 19 | Constructing Donor-Resonance-Donor Molecules for AcceptorFree Bipolar Organic Semiconductors显示文摘Organic semiconductors with bipolar transporting character are highly attractive as they offer the possibility to achieve high optoelectronic performance in simple device structures.However,the continual efforts in preparing bipolar materials are focusing on donor-acceptor(D-A)architectures by introducing both electron-donating and electron-withdrawing units into one molecule in static molecular design principles.Here,we report a dynamic approach to construct bipolar materials using only electron-donating carbazoles connected by N-P=X resonance linkages in a donor-resonance-donor(D-r-D)structure.By facilitating the stimuli-responsive resonance variation,these D-r-D molecules exhibit extraordinary bipolar properties by positively charging one donor of carbazole in enantiotropic N^(+)=P-X-canonical forms for electron transport without the involvement of any acceptors.With thus realized efficient and balanced charge transport,blue and deep-blue phosphorescent organic light emitting diodes hosted by these D-r-D molecules show high external quantum efficiencies up to 16.2%and 18.3%in vacuum-deposited and spin-coated devices,respectively.These results via the D-r-D molecular design strategy represent an important concept advance in constructing bipolar organic optoelectronic semiconductors dynamically for high-performance device applications. | He Jiang Jibiao Jin Zijie Wang Wuji Wang Runfeng Chen Ye Tao Qin Xue Chao Zheng Guohua Xie Wei Huang | 2021 | Research2021，，1： | 0 |
| 20 | Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis显示文摘Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001. | Nazi Song Hongjiao Xu Jiahua Liu Qian Zhao Hui Chen Zhibin Yan Runling Yang Zhiteng Luo Qi Liu Jianmei Ouyang Shuohan Wu Suijia Luo Shuyin Ye Runfeng Lin Xi Sun Junqiu Xie Tian Lan Zhongdao Wu Rui Wang Xianxing Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
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