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您的检索式：作者名="Minzhao Lin"
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| 1 | Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor显示文摘The dense desmoplastic stroma and immunosuppressive microenvironment of pancreatic cancer hinder the penetration of drugs and induce a considerable resistance to conventional chemoradiotherapy. Although nanomedicine has recently shown attractive potential in cancer immunotherapy, it remains a great challenge to achieve efficient drug delivery and potent immune activation.Here, a stimuli-responsive nanosystem, comprising superparamagnetic iron oxide nanocrystals and nitric oxide(NO) donors,was developed for in-situ triggered catalytic cascade reaction to produce abundant free radicals and remodel the anti-tumor immunity. The nanosystem was activated in the tumor microenvironment to produce NO which dilated the tumor vasculature for efficient drug delivery, and the iron oxide nanocrystals catalyzed the reaction of NO to generate reactive oxygen-nitrogen species(RONS) with high cytotoxicity. Moreover, owing to the catalytic cascade reactions mediated by the nanosystem, the tumor associated macrophages(TAMs) were converted to a proinflammatory M1 phenotype and tumor infiltration of effector T cells was promoted to result in potent anti-tumor immunotherapy which could be readily monitored with magnetic resonance imaging(MRI). | Gengjia Chen Yujun Cai Bo Li Minzhao Lin Xiaobin Wang Zhiyong Wang Xintao Shuai | 2022 | Science China Chemistry2022，65，7： | 1 |
| 2 | Handedness inversion of chiral mesoporous silica: A diffuse-reflectance circular dichroism study显示文摘Chiral mesoporous silica ribbons and rods with inversed handedness have been synthesized with the same enantio pure N-acylaminoacidat temperatures of 0℃and 20℃ respectively. With involving Cu^(2+)and meso-tetra(4-sulfonatophenyl)porphyrin(TPPS) as probes, ribbons and rods revealed opposite signals in diffuse-reflectance circular dichroism(DRCD) spectra, indicating the existence of inversed supramolecular chiral imprintings through helical stacking of amphiphiles. The structural evolution was systematically studied by the freeze-dried products sampled at different time after the addition of silica precursors. The H-bonding-depended molecular orientation probably controls the chiral sense upon forming chiral molecular stacking, which would be the origin of such handedness inversion | Nan Wang Ruiyu Lin Minzhao Xue Yingying Duan Shun'ai Che | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
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