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| 1 | Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease显示文摘AIM: To determine the features of Enterococcus that contribute to the development and maintenance of the inflammatory process in patients with inflammatory bowel disease (IBD). METHODS: Multiplex polymerase chain reaction (PCR) was applied to assess the presence of genes that encode virulence factors [surface aggregating protein (asa1), gelatinase (gelE), cytolysin (cylA), extracellular surface protein (esp) and hyaluronidase (hyl)] in the genomic DNA of 28 strains of Enterococcus isolated from the intestinal tissues of children with IBD (n =16) and of children without IBD (controls; n = 12). Additionally, strains with confirmed presence of the gelE gene were tested by PCR for the presence of quorum sensing genes (fsrA, fsrB, fsrC) that control the gelatinase production. Gelatinase activity was tested on agar plates containing 1.6% gelatin. We also analysed the ability of Enterococcus strains to release and decompose hydrogen peroxide (using Analytical Merckoquant peroxide test strips) and tested their ability to adhere to Caco-2 human gut epithelium cells and form biofilms in vitro. RESULTS: A comparison of the genomes of Enterococcus strains isolated from the inflamed mucosa of patients with IBD with those of the control group showed statistically significant differences in the frequency of theasa1 gene and thegelE gene. Furthermore, the cumulative occurrence of different virulence genes in the genome of a single strain ofEnterococcus isolated from the IBD patient group is greater than in a strain from the control group, although no significant difference was found. Statistically significant differences in the decomposition of hydrogen peroxide and adherence to the Caco-2 epithelial cell line between the strains from the patient group and control group were demonstrated. The results also showed that profuse biofilm production was more frequent amongEnterococcus strains isolated from children with IBD than in control strains. CONCLUSION: Enterococcus strains that adhere strongly to the intestinal epithelium, form biofilms and possess antioxidant defence mechanisms seem to have the greatest influence on the inflammatory process. | Edyta Golińska Anna Tomusiak Tomasz Gosiewski Gra yna Wiecek Agnieszka Machul Diana Mikoajczyk Magorzata Bulanda Piotr B Heczko Magdalena Strus | 2013 | World Journal of Gastroenterology2013，19，23： | 8 |
| 2 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 3 | Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications显示文摘The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body,especially infection.While tissue engineering has focused on the development of methods to regenerate and repair,until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection.In particular,local delivery of antimicrobials has long been of clinical interest,but only recently has that been translated into the realm of tissue engineering.In this perspective,we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections. | SHAH Sarita R KASPER F Kurtis MIKOS Antonios G | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
| 4 | The temperature dependence of soil organic matter decomposition, and the effect of global warming on soil organic C storage显示文摘 | Miko U.F. Kirschbaum | 1995 | Soil Biology and Biochemistry1995，，6： | 4 |
| 5 | The 4th World Landslide Forum: Landslide Research and Risk Reduction for Advancing the Culture of Living with Natural Hazards显示文摘The World Landslide Forum is a triennial mainstream conference that gathers together the scientific and technological community, policymakers, industry actors, public officials, and other stakeholders, who deal with the understanding and management of landslide disaster risk. The establishment of the ISDR-ICL Sendai Partnerships 2015–2025 for Global Promotion of Understanding and Reducing Landslide Disaster Risk in Sendai during the 2015 World Conference on Disaster Risk Reduction(WCDRR) enabled the landslide science and technology community support the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030 in order to prevent new and reduce existing disaster risk.The 4th World Landslide Forum(WLF4) was held in Ljubljana, Slovenia, from 29 May to 2 June 2017 and discussed the progress of landslide research and risk reduction for advancing the culture of living with natural hazards. A high-level panel composed of United Nations officials, international stakeholders, and national organizations sought to identify the best mechanisms to be developed by the community of the International Consortium on Landslides(ICL). The objective was to advance the implementation of the ISDR-ICL Sendai Partnerships,to achieve a better commitment among partners, and to provide substantive services to developing countries. During the WLF4, the 2017 Ljubljana Declaration on Landslide Risk Reduction was adopted and the concept framework of the Kyoto 2020 Commitment was endorsed. | Irasema Alcntara-Ayala Kyoji Sassa Matjaz Miko Quinli Han Jakob Rhyner Kaoru Takara Satoru Nishikawa Badaoui Rouhban Slvano Briceo | 2017 | International Journal of Disaster Risk Science2017，8，4： | 3 |
| 6 | Glucagon-like peptide-1 receptor imaging with [Lys 40 (Ahx-HYNIC- 99m Tc/EDDA)NH 2 ]-exendin-4 for the detection of insulinoma显示文摘 | Anna Sowa-Staszczak Dorota Pach Renata Miko?ajczak Helmut M?cke Agata Jabrocka-Hybel Agnieszka Stefańska Monika Tomaszuk Barbara Janota Aleksandra Gilis-Januszewska Maciej Ma?ecki Grzegorz Kamiński Aldona Kowalska Jan Kulig Andrzej Matyja Czes?aw Osuch Al | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，4： | 2 |
| 7 | 赤道几内亚比奥科岛献血者的输血传播感染疾病血清流行学研究和风险因素评估显示文摘目的在比奥科岛上献血人群中开展一次输血传播感染疾病(transfusion—transmissibleinfections,TTIs)的血清流行病学调查。方法用金标法和ELISA对合格献血者血样进行4项输血传播感染疾病的检测,包括人类免疫缺陷病毒(HIV)、乙型肝型病毒(HBV)、丙型肝型病毒(HCV)、梅毒螺旋体(LUES),同时用多元回归分析方法评估TTIs疾病的相关危险因素。结果在2937名献血者中HIV、HBV、HCV和梅毒螺旋体的感染率分别为7.83%(95%CI:6.85~8.80)、10.01%(95%CI:8.92~11.10)、3.71%(95%CI:3.03~4.39)和21.52%(95%CI:20.02~23.00)。多重混合感染的阳性率是6.30%(95%CI:5.42~7.18)。同时发现女性献血者的HIV和梅毒感染阳性率明显高于男性献血者(HIV:AOR=I.50,95%CI:1.10-2.04,P=0.010;梅毒:AOR=1.27,95%CI:1.02~1.58,P=0.034)。岛上的未规划居住区是艾滋病、乙肝和梅毒感染的显著危险因素(HIV:AOR=I.66,95%CI:1.04~2.66,P=-0.033;HBV:AOR=I.78,95%CI:1.11~2.83,P=-0.016;梅毒:AOR=I.73,95%CI:1.26-2.37,P=-0.001)。结论比奥科岛的献血人群中输血传播感染的阳性率极高,当地政府和卫生部门应采取更有效的干预措施来提高血液安全。 | 谢东德 陈江涛 Urbano Monsuy Eyi Rocio Apicante Matesa Maximo Miko Ondo Obono Carlos Sala Ehapo 郑艳芬 詹小芬 杨辉 杨惠钿 杨立业 章光华 荆磊 林敏 | 2014 | 分子诊断与治疗杂志2014，6，1： | 2 |
| 8 | Early stent thrombosis secondary to food allergic reaction:Kounis syndrome following rice pudding ingestion显示文摘Kounis syndrome is the concurrence of coronary spasm, acute myocardial infarction or stent thrombosis, with allergic reactions in the setting of mast-cell and platelet activation. In this report Kounis syndrome manifesting as stent thrombosis with left ventricular thrombus formation was triggered by a food-induced allergic reaction. The allergic reaction to food was confirmed by oral rice pudding ingredients challenge test while skin tests were inconclusive. To our knowledge, this is first report of early stent thrombosis secondary to food allergic reaction in a 70-year-old man patient who was found to have left ventricular thrombus and undiagnosed hypertrophic cardiomyopathy. | Georgios Tzanis Maria Bonou Nikolaos Mikos Smaragda Biliou Ioanna Koniari Nicholas G Kounis John Barbetseas | 2017 | World Journal of Cardiology2017，9，3： | 2 |
| 9 | Laminated three-dimensional biodegradable foams for use in tissue engineering显示文摘 | Mikos A G Sarakinos G Leite S M | 1993 | Biomaterials1993，14，： | 1 |
| 10 | Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy显示文摘 | Szereday L Miko E Meggyes M | 2012 | AmJ Reprod Immunol2012，67，： | 1 |
| 11 | Does laterality of motor impairment tell us something about cognition in Parkinson disease?显示文摘 | Cooper CA Mikos AE Wood MF | 2009 | Parkinsonism Relat Disord2009，15，31： | 1 |
| 12 | Recent progress in gene delivery using non-viral transfer complexes 显示文摘 | GODBEY W T MIKOS A G | 2001 | J Controlled Release2001，72，13： | 1 |
| 13 | Evaluation of terra rossa geochemical baselines from Croatian karst regions显示文摘 | Miko S Durn G Prohic E | 1999 | Journal of Geochemical Exploration1999，66，2： | 1 |
| 14 | Bone tissue engineering显示文摘 | Grane GM Lshaug SL Mikos AG | | 0，，12： | 1 |
| 15 | Thermoresponsive hydrogels in biomedical applications显示文摘 | Leda Klouda Antonios G. Mikos | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，1： | 1 |
| 16 | Advances in drag deliveryfor articular cartilage 显示文摘 | Holland TA Mikos AG | 2003 | Control Release2003，86，1： | 1 |
| 17 | Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery显示文摘 | Wu K K Mikos A G | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 18 | Engineering complex tissues 显示文摘 | Mikos AG Herring SW Ochareon P | 2006 | Tissue Eng2006，12，： | 1 |
| 19 | Investigation of the C02 Dependence of Quantum Yield and Respiration in Eucalyptus Pauciflora 显示文摘 | Miko U F K Graham D F | 1987 | Plant Physiology1987，83，4： | 1 |
| 20 | Growing new organs显示文摘 | Mooney DJ Mikos AG | 1999 | Sci Am1999，280，4： | 1 |
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