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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Value of prealbumin plasma levels as liver test显示文摘 | Rondana M Milani L Merkel C | 1987 | Digestion1987，37，2： | 1 |
| 3 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 4 | Value of prealbumin plasma levels as liver test 显示文摘 | Rondana M Milani L Merkel C | 1987 | Digestion1987，37，2： | 1 |
| 5 | Electroencephalographic and psychometric differences between boys with and without attention deficit hyperactivity disorder(ADHD): a pilot study 显示文摘 | Cox DJ Kovatchev BP Morris JB Jr Phillips C Hill RJ Merkel L | 1998 | Appl Psychophysiol Biofeedback1998，23，3： | 1 |
| 6 | Effect of aspect ratio anddeformability on nanoparticle extravasation through nanopores显示文摘 | Kersey F R Merkel T J Perry J L | 2012 | Langmuir2012，28，23： | 1 |
| 7 | Morphology and grafting reactions in core/shell latexes 显示文摘 | MERKEL M P DIMONIE V L El-AASSER M S et al | 1987 | Journal of Polymer Science Part A : Polymer Chemistry1987，25，5： | 1 |
| 8 | Parallel Incorporation of different fluorinated amino acids: on the way to 'teflon' proteins 显示文摘 | Merkel L Schauer M Antranikian G | 2010 | ChemBioChem2010，11，11： | 1 |
| 9 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lü uddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 10 | Process parameters and their grafting reactions in core/shell latexes 显示文摘 | MERKEL M P DIMONIE V L EI-AASSER M S | 1987 | J Polym Sci Part A: Polym Chem1987，25，： | 1 |
| 11 | Reducing Unplanned Ex- tubations in the NICU 显示文摘 | Merkel L Beers K Lewis MM | 2014 | Pediatrics2014，133，5： | 1 |
| 12 | Detection of gunshot residues in routine CTs 显示文摘 | Stein K M Bahner M L Merkel J | 2000 | Int J Legal Med2000，114，： | 1 |
| 13 | Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes显示文摘 | Merkel MJ Liu L Cao Z | 2008 | Am J Physiol Heart Circ Physiol2008，295，1： | 1 |
| 14 | Cricoarytenoid subluxation, computed tomography, and electromyography findings显示文摘 | Close L G Merkel M Watson B | 1987 | Head Neck Surg1987，9，6： | 1 |
| 15 | Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors显示文摘 | Tam C Rink L Merkel E | 2008 | Proc Nat Acad Sci USA2008，105，24： | 1 |
| 16 | Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors 显示文摘 | Tran C Rink L Merkel E | 2008 | Proc Natl Acad Sei U S A2008，105，24： | 1 |
| 17 | Insulin-like growth factor 1 re- ceptor is a potential therapeutic target for gastrointestinal stromal tumors显示文摘 | Tam C Rink L Merkel E | 2008 | P Natl Acad Sci USA2008，105，24： | 1 |
| 18 | Ploidy, proliferative activity and prognosis: DNA flow cytometry of solid tumors 显示文摘 | Merkel D E Me Guire W L | 1990 | Cancer1990，65，5： | 1 |
| 19 | Value of prealbumin plasma levels as liver test显示文摘 | Rondana M Milani L Merkel C | 1987 | Digestion1987，37，2： | 1 |
| 20 | Process pa- rameters and their effect on grafting reactions in core/shell la- texes显示文摘 | Merkel M P Dimonie V L EI-Aasser M S | 1987 | J Polym Sci(part A): Polym Chem1987，25，7： | 1 |
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