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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | A placebo-controlled clini- cal trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis显示文摘 | MERKEL C MARIN R ANGELI P | 2004 | Gastroenterology2004，127，： | 1 |
| 3 | Insulin and glucose regulate the expression of the DNA repair enzyme XPD 显示文摘 | Merkel P Khoury N Bertolotto C | 2003 | Mol Cell Endocrinol2003，201，12： | 1 |
| 4 | Value of prealbumin plasma levels as liver test显示文摘 | Rondana M Milani L Merkel C | 1987 | Digestion1987，37，2： | 1 |
| 5 | The hemody- namic response to medical treatment of portal hyertension as a predic- tor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis显示文摘 | MERKEL C BOLOGNESI M SACERDOTI D | 2000 | Hepatology2000，32，： | 1 |
| 6 | Pathogenesis and management of hepa- torenal syndrome in patients with cirrhosis 显示文摘 | Angeli P Merkel C | 2008 | J Hepatol2008，48，： | 1 |
| 7 | Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics显示文摘 | Merkel C | 1995 | Gastroenterology1995，108，： | 1 |
| 8 | Architecture and material properties of diatom shells provide effective mechanical protection 显示文摘 | Hamm C E Merkel R Springer O 2003 | 2003 | Nature2003，421，6925： | 1 |
| 9 | Effect of nanoparticles on gas sorption and trans- port in poly ( 1 - trimethylsilyl - 1 - propyne)显示文摘 | Merkel T C He Z Pinnau I | 2003 | Macromolecules2003，36，： | 1 |
| 10 | Landscape of transcription in human cells 显示文摘 | Djebali S Davis C A Merkel A | 2012 | Nature2012，489，7414： | 1 |
| 11 | Lithofacies identification using multiple adaptive resonance theory networking and group and group decision expert system 显示文摘 | CHANG Hsiencheng KOPASKAMERKEL D C CHEN Huichuan | 2000 | Computer & Geosciences2000，26，： | 1 |
| 12 | Effects of chronic therapy with nadoll on portal hemodynamics and on splanchnic impedance indices using Doppler sonography: comparison between acute and chronic effects 显示文摘 | Bolognesi M Saeerdoti D Merkel C | 1997 | Journal of Hepatology1997，26，2： | 1 |
| 13 | Role of spleen enlargement in cirrhosis with portal hypertension显示文摘 | Bolognesi M Merkel C Sacerdoti D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 14 | Value of prealbumin plasma levels as liver test 显示文摘 | Rondana M Milani L Merkel C | 1987 | Digestion1987，37，2： | 1 |
| 15 | Electroencephalographic and psychometric differences between boys with and without attention deficit hyperactivity disorder(ADHD): a pilot study 显示文摘 | Cox DJ Kovatchev BP Morris JB Jr Phillips C Hill RJ Merkel L | 1998 | Appl Psychophysiol Biofeedback1998，23，3： | 1 |
| 16 | Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics 显示文摘 | Sacerdoti D Merkel C Bolognesi M | 1995 | Gastroenterology1995，108，： | 1 |
| 17 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 18 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，1： | 1 |
| 19 | Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis:a haemodynamic study显示文摘 | Merkel C Schipilliti M Bighin R | 2003 | Dig Liver Dis2003，35，： | 1 |
| 20 | Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis:A haemodynamic study显示文摘 | Merkel C Schipilliti M Bighin R | 2003 | Dig Liver Dis2003，35，： | 1 |
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