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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Frequency of micronu clei in lymphocytes from a group of floriculturists exposed to pesticides显示文摘 | Bolognesi C Parrini M Merlo F | 1993 | J Toxicol Environ Heahh1993，40，40： | 1 |
| 3 | Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts 显示文摘 | Antonello M Montemurro D Bolognesi M | 2007 | American Journal of Hypertension2007，20，12： | 1 |
| 4 | The hemody- namic response to medical treatment of portal hyertension as a predic- tor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis显示文摘 | MERKEL C BOLOGNESI M SACERDOTI D | 2000 | Hepatology2000，32，： | 1 |
| 5 | Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils显示文摘 | ROMEO D SKERLAVAJ B BOLOGNESI M | 1988 | J Biol Chem1988，263，20： | 1 |
| 6 | The allosteric regulation of pyruvate kinase显示文摘 | Mattevi A Bolognesi M Valentini G | 1996 | FEBS Lett1996，389，1： | 1 |
| 7 | Selenomethionine in- hibits IL-1β inducible nitric oxide synthase(iNOS) and cyclooxy- genase 2 (COX2) expression in primary human chondrocytes 显示文摘 | Cheng A W Stabler T V Bolognesi M | 2011 | Osteoarthritis Cartilage2011，19，1： | 1 |
| 8 | Effects of chronic therapy with nadoll on portal hemodynamics and on splanchnic impedance indices using Doppler sonography: comparison between acute and chronic effects 显示文摘 | Bolognesi M Saeerdoti D Merkel C | 1997 | Journal of Hepatology1997，26，2： | 1 |
| 9 | Arterioportal fistulas in patients with liver cirrhosis:usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2000 | Radiology2000，216，3： | 1 |
| 10 | Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients显示文摘 | Rossi GP Bolognesi M Rizzoni D | | 0，，05： | 1 |
| 11 | Role of spleen enlargement in cirrhosis with portal hypertension显示文摘 | Bolognesi M Merkel C Sacerdoti D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 12 | Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics 显示文摘 | Sacerdoti D Merkel C Bolognesi M | 1995 | Gastroenterology1995，108，： | 1 |
| 13 | Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different Antag onism toward α1-Adrenoreceptor subtypes 显示文摘 | Bolognesi M L Marucci G | 2001 | J Med Chem2001，44，： | 1 |
| 14 | Neuroglobin and cytoglobin, Fresh blood for the vertebrate globin family 显示文摘 | Pesce A Bolognesi M Bocedi A | 2002 | EMBO reports2002，3，12： | 1 |
| 15 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 16 | Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients显示文摘 | ROSSI G P BOLOGNESI M RIZZONI D | | 0，，05： | 1 |
| 17 | Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a tri- functional compound against Alzheimer's disease 显示文摘 | BOLOGNESI M L CAVALLI A VALGIMIGLI L | 2007 | J Med Chem2007，50，26： | 1 |
| 18 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，1： | 1 |
| 19 | Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato C | 2000 | Radiology2000，216，3： | 1 |
| 20 | Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer' s disease 显示文摘 | Bolognesi M L Cavalli A Valgimigli L | 2007 | J Med Chem2007，50，26： | 1 |
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