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| 1 | MRI阴性药物难治性颞叶癫痫合并抑郁症患者的静息态功能磁共振研究显示文摘背景抑郁症在颞叶癫痫中发生率高达50%~60%,而30%的药物难治性颞叶癫痫患者可表现为头颅核磁共振(MRI)无明显异常,这部分患者相较于伴有海马硬化的药物难治性颞叶癫痫患者出现继发性全面强直阵挛发作的机率更高。因此,MRI阴性药物难治性颞叶癫痫合并抑郁症的患者,生活质量更差、自杀风险更高,更需要癫痫外科手术治疗。 | 朱曦 陈蕾 罗程 Zhu X He Z Luo C | 2018 | 癫痫杂志2018，4，3： | 11 |
| 2 | Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine显示文摘Objectives To trace and evaluate intracoronary transplanted mesenchymal stem cells(MSCs) labeled with superparamagnetic iron oxide(SPIO) by using magnetic resonance imaging(MRI) in a swine model of myocardial infarction (MI).Methods MSCs were transfected with a lentiviral vector carrying the gene encoding green fluorescent protein (GFP) and labeled in vitro with SPIO.Two weeks after MI, swine were randomized to intracoronary transplantation of dual -labeled MSCs(n = 10),MSCs-GFP(n = 10) and saline(n = 5).MRI examination was performed with a 1.5T clinical scanner at 24 hours,3 weeks and 8 weeks after cells transplantation. Signal intensity(SI) changes,cardiac function and MI size were measured using MRI.Correlation between MR findings and histomorphologic findings was also investigated. Results The labeling efficiency at a combination of 25μg Fe/ml SPIO and 0.8 pi/ml Lipofectamine 2000 reached 100%.SPIO labeling did not affect GFP fluorescence and dual-labeling did not affect cell proliferation(P>0.05). Multipotentiality was not affected especially for cardiomyocyte-like cells differentiation.Cardiac cell marker of a-MHC and actinin were positively expressed by immunofluorescence staining after induction.SI on T2 * WI decreased substantial- ly in the interventricular septum 24 hours after injection of MSCs.The intensity of hypo-intense signals appeared to increase throughout the later time points.Changes in SI at 24 hours,3 weeks and 8 weeks were 52.98%±10.74%,21.53%±5.40%and 6.23%±2.01%,respectively(P<0.01).DE-MRI demonstrated both dual-labeled MSCSs and MSCs-GFP could dramatically reduce the size of MI and improve cardiac function. Histological data revealed that prussian blue stain-positive cells were found mainly in the border zone which also showed green fluorescence but negative for macrophage marker(CD68).Gross pathologic examination revealed that engrafted MSCs dramatically reduce the extent of necrotic myocardium and promote the regeneration of new,contractile myocardium along the subendocardial surface of the MI. Conclusions MSCs could be efficiently and safely labeled with SPIO and GFP,and could be detected reproducibly and noninvasively in vivo using cardiac MRI.Intracoronary transplantation of dual-labeled MSCs could increase cardiac function and reduce the size of MI. | KE Yang~1,PENG Chao-quan~1,XIANG Peng~1,ZHANG Cheng-xi~1, ZOU Li-yuan~1,WU Xiao~1,YA Gao~1,KANG Z huang~2,HE Ke-ke~2,LIU Jin-lai~1 (1.Department of Cardiology,The Third Affiliated Hospital, Sun Yat-sen University,Guangzhou 2.Department of Radiology, the Third Affiliated Hospital,Sun Yat-sen University, Guangzhou 5100630 3.Center for Stem Cell Biology and Tissue Engineering,Sun Yat-sen University,Guangzhou 5100120) | 2011 | 岭南心血管病杂志2011，17，S1： | 7 |
| 3 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 4 | Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases显示文摘 | Liu W He X Cao Z Sheng J Liu H Li Z Li W | 2006 | 中国生物学文摘2006，20，10： | 5 |
| 5 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 6 | Utilization of Thermal Infrared Image for Inversion of Winter Wheat Yield and Biomass显示文摘The present paper utilizes thermal infrared image for inversion of winter wheat yield and biomass with different technology of irrigation(drip irrigation,sprinkler irrigation,flood irrigation).It is the first time that thermal infrared image is used for predicting the winter wheat yield and biomass.The temperature of crop and background was measured by thermal infrared image.It is necessary to get the crop background separation index(CBSIL,CBSIH),which can be used for distinguishing the crop value from the image.CBSIL and CBSIH(the temperature when the leaves are wet adequately;the temperature when the stomata of leaf is closed completely) are the threshold values.The temperature of crop ranged from CBSIL to CBSIH.Then the ICWSI was calculated based on relevant theoretical method.The value of stomata leaf has strong negative correlation with ICWSI proving the reliable value of ICWSI.In order to construct the high accuracy simulation model,the samples were divided into two parts.One was used for constructing the simulation model,the other for checking the accuracy of the model.Such result of the model was concluded as:(1) As for the simulation model of soil moisture,the correlation coefficient(R2) is larger than 0.887 6,the average of relative error(Er) ranges from 13.33% to 16.88%;(2) As for the simulation model of winter wheat yield,drip irrigation(0.887 6,16.89%,-0.12),sprinkler irrigation(0.970 0,14.85%,-0.12),flood irrigation(0.969 0,18.87%,0.18),with the values of R2,Er and CRM listed in the parentheses followed by the individual term.(3) As for winter wheat biomass,drip irrigation(0.980 0,13.70%,0.13),sprinkler irrigation(0.95,13.15%,-0.14),flood irrigation(0.970 0,14.48%,-0.13),and the values in the parentheses are demonstrated the same as above.Both the CRM and Er are shown to be very low values,which points to the accuracy and reliability of the model investigated.The accuracy of model is high and reliable.The results indicated that thermal infrared image can be used potentially for inversion of winter wheat yield and biomass. | DU Wen-yong ZHANG Lu-da HU Zhen-fang Shamaila Z ZENG Ai-jun SONG Jian-li LIU Ya-jia Wolfram S Joachim M HE Xiong-kui | 2011 | 光谱学与光谱分析2011，31，6： | 3 |
| 7 | Islet separation and islet cell culture in vitro from human embryo-pancreas显示文摘 | Yuan Z Wu GY He YS Shao CM Zhan Y | 1999 | World Journal of Gastroenterology1999，5，5： | 3 |
| 8 | Differentiation renders susceptibility to excitotoxicity in HT22 neurons显示文摘HT22 is an immortalized mouse hippocampal neuronal cell line that does not express cholinergic and glutamate receptors like mature hippocampal neurons in vivo.This in part prevents its use as a model for mature hippocampal neurons in memory-related studies.We now report that HT22 cells were appropriately induced to differentiate and possess properties similar to those of mature hippocampal neurons in vivo,such as becoming more glutamate-receptive and excitatory.Results showed that sensitivity of HT22 cells to glutamate-induced toxicity changed dramatically when comparing undifferentiated with differentiated cells,with the half-effective concentration for differentiated cells reducing approximately two orders of magnitude.Moreover,glutamate-induced toxicity in differentiated cells,but not undifferentiated cells,was inhibited by the N-methyl-Daspartate receptor antagonists MK-801 and memantine.Evidently,differentiated HT22 cells expressed N-methyl-D-aspartate receptors,while undifferentiated cells did not.Our experimental findings indicated that differentiation is important for immortalized cell lines to render post-mitotic neuronal properties,and that differentiated HT22 neurons represent a better model of hippocampal neurons than undifferentiated cells. | Minchao He Jun Liu haowu Cheng Yigang Xing William Z Suo | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 9 | Role of matrix metalloproteinase in pituitary tumor behavior 显示文摘 | Turner HE Nagy Z Esiri MM | 2000 | Clin Endocrinol Metab2000，85，8： | 1 |
| 10 | PZT-based materials with bilayered structure preparation and ferroelectric properties显示文摘 | He Z M Ma J Zhang R F | 2003 | Journal of the European Creamic Society2003，23，11： | 1 |
| 11 | Grain Size Dependence of Anatase-to-rutile Structural Transformation in Gel-derived Nanocrystalline Titania Powders显示文摘 | DING X Z LIU X H HE Y Z | 1996 | J Mater Sci Lett1996，15，20： | 1 |
| 12 | Test results for three prototype models of a linear induction launcher显示文摘 | Zabar Z Lu X N He J L | 1991 | IEEE Transactions on Magnetics1991，27，1： | 1 |
| 13 | Electrodeposition of Pt-Ru nanoparticles on carbon nanotubes and their electrocatalytic properties for methanol electrooxidation 显示文摘 | He Z B Chen J H Liu D Y | 2004 | Diamond and Related Materials2004，13，10： | 1 |
| 14 | Macorkinetic analysis of blockade of NMDA-gated Currents by substituted alcohols, alkanes and ethers显示文摘 | Crlswdl HE Ming Z Pleasant N | 2004 | Brain Res2004，1015，12： | 1 |
| 15 | Analysis of driving factors of grain output in Henan province based on grey correlation model显示文摘 | HE Z | 2009 | Agricultural Science & Technology2009，10，12： | 1 |
| 16 | Effect of heating rate on pore structure of porous FeA1 material 显示文摘 | GAO H Y HE Y H SHEN P Z | 2008 | Powder Metallurgy2008，51，2： | 1 |
| 17 | A soluble 5-carbasolium 8- hydroxyquinoline Al(Ⅲ) complex as a dipolar luminescent material 显示文摘 | Xie J T Ning Z J He T | 2005 | Tetrohedron Letters2005，46，49： | 1 |
| 18 | Application of an intelligent classification method to mechanical fault diagnosis显示文摘 | LEI Y G HE Z J ZI Y Y | 2009 | Expert Systems with Applications2009，36，6： | 1 |
| 19 | Risk management for overseas construction projects显示文摘 | He Z | 1995 | International Journal of Project Management1995，13，4： | 1 |
| 20 | 3-D position sensitive CdZnTe gamma ray spectremeters显示文摘 | He Z Li W Knoll G F | 1999 | Nucl Instr and Meth in Phys Res1999，422，： | 1 |
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