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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris M C Chaloin L Mery J | 1999 | Nucleic Acids Res1999，27，17： | 1 |
| 3 | Overexpression of CRT increases intraeellular Ca2+ storage and decreases storeoperated Ca2+ influx显示文摘 | MERY L MESAELI N MICHALAK M | 1996 | J Biol Chem1996，271，6： | 1 |
| 4 | Relationship between a his- tory of antecedent cancer and the probability of malignancy for a sol- itary pulmonary nodule显示文摘 | Mery C M Pappas A N Bueno R | 2004 | Chest2004，125，6： | 1 |
| 5 | Large-eddy simu- lation of oxygen/methane flames under transcritical con- ditions显示文摘 | Schmitt T Mery Y Boileau M | 2011 | Proceedings of the Combustion Institute2011，33，1： | 1 |
| 6 | Inflammasome-essential regulator ofthe inflammatory reaction 显示文摘 | Junttila I Meri S Ramet M | 2013 | Duodecim2013，129，7： | 1 |
| 7 | A peptide carrier for the delivery of biologically active proteins into mammalian cells显示文摘 | Morris M Depollier J Mery J | 2001 | Nature Biotech2001，19，12： | 1 |
| 8 | A peptide carrier for the delivery of biologically active proteins into mammalian cells 显示文摘 | Morris M C Depollier J Mery J Heitz F Divita G | 2001 | Nat Biotechnol2001，19，： | 1 |
| 9 | Iron deficiency anemia in the eLderLy:prevaLence and endoscopic evaLuation of the gastrointestinaL tract in out patients显示文摘 | Coban E TimuragaogLu A Merie M | 2003 | Acta HaematoL2003，10，1： | 1 |
| 10 | Value of cytokeratin 5/6 immunostaining using D5/6 B4 antibody in the spectrum of proliferative intraepithelial lesions of the breast: a comparative study with 34βE12 antibody 显示文摘 | Lacroix-Triki M Mery E Voigt JJ | 2003 | Virchows Arch2003，442，： | 1 |
| 11 | Indexes of severity for osteoarthritis of the hip and knee显示文摘 | Leauesne M G Mery C | 1987 | Scand J Rheumatol Suppl1987，65，： | 1 |
| 12 | Follicular growth in vitro: detection of growth differentiation factor 9 (GDFg) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices显示文摘 | Mery L Lefevre A Benchaib M | 2007 | Mol Reprod Dev2007，74，6： | 1 |
| 13 | Molecular genetic characterization of the fen- noscandian cervid strain, a new genotypic group (G10) of Echinococcus granulosus 显示文摘 | LAVIKAINEN A LEHTINEN M J MERI T | 2003 | Parasitolo- gy2003，127，3： | 1 |
| 14 | Inhibition of eukaryote protein kinases and of a cyclic nucleotide-bind- ing phosphatase by prenylated xanthones 显示文摘 | LU Z X MERY H WILAWAN M | 1998 | Chem Biol Interact1998，114，12： | 1 |
| 15 | Fine-tuning in Ca^2+ homeostasis underlies progression of cardiomyopathy in myocytes derived from genetically modifled embryonic stem cells显示文摘 | Grey C Mery A Puceat M | 2005 | Hum Mol Genet2005，14，10： | 1 |
| 16 | The importance of combined coronary anglography and renal angiography in patients with hypertension and isehemie heart disease显示文摘 | Helvaci A Aalet K Merie M | 1996 | Ist Tip Faku Metro1996，59，： | 1 |
| 17 | Similar longterm survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance,epidemiology and end-results database显示文摘 | Mery C M Pappas A N Bueno R | 2005 | Chest2005，128，1： | 1 |
| 18 | Early histologic changes following polymethylmethacrylate injection(vertebroplasty) in rabbit lumbar vertebrae显示文摘 | Urrutia J Bono C M Mery P | 2008 | Spine2008，33，8： | 1 |
| 19 | Urban aerosol number size distributions显示文摘 | Hussein T. Puustinen A. Aalto P. P. M?kel? J. M. H?meri K. Kulmala M | 2004 | Atmospheric Chemistry and Physics2004，，37： | 1 |
| 20 | A peptide carrier for thedelivery of biologically active proteins into mammalian cells显示文摘 | Morris M C Depollier J Mery J | 2001 | Nat Biotechnol2001，19，12： | 1 |
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