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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases 显示文摘 | Heitz F Harter P Lueck HJ | 2009 | Eur J Cancer2009，45，16： | 1 |
| 3 | Discrete markov image modeling and inference on the quadtree显示文摘 | J M Laferté P Pérez F Heitz | 2000 | IEEE Trans Image Processing2000，9，3： | 1 |
| 4 | Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy 显示文摘 | Deshayes S Morris M Heitz F | 2008 | Adv Drug Deliv Rev2008，60，45： | 1 |
| 5 | Topology preserving de- formable image matching using constrained hierarchical parametric models 显示文摘 | MUSSE O HEITZ F ARblSPACH J-P | 2001 | IEEE Transactions on Image Processing2001，10，7： | 1 |
| 6 | Determination of Sixteen Polycyclic Aromatic Hydrocarbons in Aqueous and Solid Samples From an Italian Wastewater Treatment Plant显示文摘 | BUSETTI F HEITZ A CUOMO M | 2006 | Journal of Chromatography A2006，1102，12： | 1 |
| 7 | Cell-penetrating peptides: from molecular mechanisms to therapeutics 显示文摘 | Morris MC Deshayes S Heitz F | 2008 | Biol Cell2008，100，4： | 1 |
| 8 | Staging laparoscopy for the management of early-stage ovarian cancer: a meta analysis显示文摘 | Heitz F Harter P du Bois A | 2013 | Am J Obstet Gynecol2013，209，6： | 1 |
| 9 | Determination of sixteen polycyclic aromatic hydrocarbons in aqueous and solid samples from an Italian wastewater treatment plant 显示文摘 | Busetti F Heitz A Cuomob M Badoer S Traverso P | 2006 | Journal of Chromatography A2006，1102，： | 1 |
| 10 | Direct diagnosis by DNA analysis of the fragile X Syndrome of mental retardation显示文摘 | Rousseau F Heitz D Biancalana V | 1991 | N Eng J Med1991，325，24： | 1 |
| 11 | The multidrug resistance modulator valspodar(PSC833)is metabolized by human cytochrome P450 3A:implications for drug-drug interactions and pharmacological activity of the main metabolite显示文摘 | Fischer V Rodriguez GA Heitz F | 1998 | Drug Metab Dispos1998，26，： | 1 |
| 12 | Current and future options in the management and treatment of uterine sarcoma显示文摘 | El-Khalfaoui K du Bois A Heitz F | 2014 | Ther Adv Med Oncol2014，6，1： | 1 |
| 13 | Abdominal wall metaslases in patients with ovarian cancer after laparoseopic surgery: incidence,risk faclors,and complications 显示文摘 | Heitz F Ognjenovic D Harter P | 2010 | Int J Gynecol Cancer2010，20，1： | 1 |
| 14 | The peptide carrier Pep-1 forms biologically efficient nanoparticle complexes显示文摘 | MUNOZ-MORRIS M A HEITZ F DIVITA G | 2007 | Biochem Biophys Res Commun2007，355，4： | 1 |
| 15 | Twenty years of cell-penetrating peptides:from molecular mechanisms to therapeutics显示文摘 | HEITZ F MORRIS M C DIVITA G | 2009 | Br J Pharmacol2009，157，2： | 1 |
| 16 | Individual diferences in the fan effect and working memory capacity显示文摘 | Bunting M F Conway A R A Heitz R P | 2004 | Journal of memory and language2004，51，4： | 1 |
| 17 | 显示文摘 | Heitz M P Bright F V | 1996 | J Phys Chem1996，100，： | 1 |
| 18 | A peptide carrier for the delivery of biologically active proteins into mammalian cells 显示文摘 | Morris M C Depollier J Mery J Heitz F Divita G | 2001 | Nat Biotechnol2001，19，： | 1 |
| 19 | Multi-reference shape priors for active contours 显示文摘 | Foulonneau A Charbonnier P Heitz F | 2009 | International Journal of Computer Vision2009，81，1： | 1 |
| 20 | Multimodal estimation of discontinuous optical flow using Markov random fields 显示文摘 | Heitz F Bouthemy P | 1993 | IEEE Transactions on Pattern Analysis and Machine Intelligence(S0162-8828)1993，15，12： | 1 |
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